We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
BIO-RAD LABORATORIES

Download Mobile App




3D Hydrogel Structures Developed for Biomedical Use

By LabMedica International staff writers
Posted on 13 Feb 2018
Print article
Image: A three-dimensional-printed chess king shrinking and growing as water temperatures change (Photo courtesy of Daehoon Han, Rutgers University).
Image: A three-dimensional-printed chess king shrinking and growing as water temperatures change (Photo courtesy of Daehoon Han, Rutgers University).
A team of biomedical engineers developed a three-dimensional printing method for stimuli-responsive hydrogels that may enable many new applications in diverse areas, including flexible sensors and actuators, biomedical devices, and tissue engineering.

Investigators at Rutgers University (New Brunswick, NJ, USA) used a high-resolution digital additive manufacturing technique known as projection micro-stereolithography to fabricate structures from the temperature-responsive polymer Poly(N-isopropylacrylamide) (PNIPAAm).

PNIPAAm was first synthesized in the 1950s from N-isopropylacrylamide, which is commercially available. It is prepared via free-radical polymerization and is readily functionalized making it useful in a variety of applications. It forms a three-dimensional hydrogel when cross-linked with N,N’-methylene-bis-acrylamide (MBAm) or N,N’-cystamine-bis-acrylamide (CBAm). When heated in water above 32 degrees Celsius, it undergoes a reversible lower critical solution temperature (LCST) phase transition from a swollen hydrated state to a shrunken dehydrated state, losing about 90% of its volume. Since PNIPAAm expels its liquid contents at a temperature near that of the human body, it has been investigated by many researchers for possible applications in tissue engineering and controlled drug delivery.

For the current study, control of the temperature dependent deformation of three-dimensional printed PNIPAAm was achieved by controlling the manufacturing process parameters as well as the polymer resin composition. A report on the process published in the January 31, 2018, online edition of the journal Scientific Reports described the sequential deformation of a three-dimensional printed PNIPAAm structure by selective incorporation of ionic monomer that shifted the swelling transition temperature of PNIPAAm.

“If you have full control of the shape, then you can program its function,” said senior author Dr. Howon Lee, assistant professor of mechanical and aerospace engineering at Rutgers University. “I think that is the power of three-dimensional printing of shape-shifting material. You can apply this principle almost everywhere. The full potential of this smart hydrogel has not been unleashed until now. We added another dimension to it, and this is the first time anybody has done it on this scale. They are flexible, shape-morphing materials. I like to call them smart materials.”

Related Links:
Rutgers University

New
Platinum Member
Flu SARS-CoV-2 Combo Test
OSOM® Flu SARS-CoV-2 Combo Test
Magnetic Bead Separation Modules
MAG and HEATMAG
Complement 3 (C3) Test
GPP-100 C3 Kit
New
Gold Member
Automatic ELISA Workstation
URANUS AE65

Print article

Channels

Clinical Chemistry

view channel
Image: The new ADLM guidance will help healthcare professionals navigate respiratory virus testing in a post-COVID world (Photo courtesy of 123RF)

New ADLM Guidance Provides Expert Recommendations on Clinical Testing For Respiratory Viral Infections

Respiratory tract infections, predominantly caused by viral pathogens, are a common reason for healthcare visits. Accurate and swift diagnosis of these infections is essential for optimal patient management.... Read more

Molecular Diagnostics

view channel
Image: The HelioLiver Dx test has met the coprimary and secondary study endpoints in the CLiMB trial (Photo courtesy of Helio Genomics)

Blood-Based Test Outperforms Ultrasound in Early Liver Cancer Detection

Patients with liver cirrhosis and chronic hepatitis B are at a higher risk for developing hepatocellular carcinoma (HCC), the most prevalent type of liver cancer. The American Association for the Study... Read more

Hematology

view channel
Image: The CAPILLARYS 3 DBS devices have received U.S. FDA 510(k) clearance (Photo courtesy of Sebia)

Next Generation Instrument Screens for Hemoglobin Disorders in Newborns

Hemoglobinopathies, the most widespread inherited conditions globally, affect about 7% of the population as carriers, with 2.7% of newborns being born with these conditions. The spectrum of clinical manifestations... Read more

Microbiology

view channel
Image: The POC PCR test shortens time for STI test results (Photo courtesy of Visby Medical)

POC STI Test Shortens Time from ED Arrival to Test Results

In a 2024 sexually transmitted infections (STIs) surveillance report by the World Health Organization (WHO), over 2.5 million cases were recorded, alongside a rise in the inappropriate use of antibiotics... Read more

Industry

view channel
Image: For 46 years, Roche and Hitachi have collaborated to deliver innovative diagnostic solutions (Photo courtesy of Roche)

Roche and Hitachi High-Tech Extend 46-Year Partnership for Breakthroughs in Diagnostic Testing

Roche (Basel, Switzerland) and Hitachi High-Tech (Tokyo, Japan) have renewed their collaboration agreement, committing to a further 10 years of partnership. This extension brings together their long-standing... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.