We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App

New Class of Bloodstream Infection Diagnostics to Enable Culture-Free, Same-Day Organism Identification

By LabMedica International staff writers
Posted on 21 Nov 2023
Print article
Image: Keynome ID is a proprietary algorithm that classifies the bacterial species present in a sample (Photo courtesy of Day Zero Diagnostics)
Image: Keynome ID is a proprietary algorithm that classifies the bacterial species present in a sample (Photo courtesy of Day Zero Diagnostics)

The World Health Organization reports that sepsis-related complications lead to 11 million deaths annually, making up a fifth of all global deaths. Sepsis, a severe infection, demands prompt and effective treatment as mortality risks escalate with each passing hour. Traditional culture-based diagnostic methods, which take days to identify pathogens and determine antimicrobial susceptibility, contribute to either excessive or insufficient treatment, particularly when antibiotic-resistant organisms are involved. This situation underscores the urgent need for rapid diagnostic technologies capable of identifying pathogens and providing antimicrobial susceptibility results within hours, thus guiding effective therapy.

Oxford Nanopore (Oxford, UK) and Day Zero Diagnostics (Boston, MA, USA) have entered into a collaboration to develop a comprehensive diagnostic solution for bloodstream infections, a major cause of sepsis. This collaboration will seek to develop a diagnostic system that offers same-day pathogen identification and genomic-based antibiotic susceptibility profiles without the need for blood cultures. Both companies aim to streamline this system for clinical environments, such as hospitals, and plan to pursue regulatory approvals, including clearance from the FDA, in the future.

This innovative diagnostic system will combine Day Zero Diagnostics’ advanced sample preparation technology, which highly enriches samples, with its AI-powered Keynome technology. Keynome is adept at identifying microbes and determining antibiotic susceptibility. This system will be paired with sequencing data from Oxford Nanopore's PromethION 2 Solo, a high-throughput, compact sequencing device. The partnership is focused on creating an automated workflow for sample processing and sequencing that is tailored to the operational demands of clinical hospital laboratories. The PromethION 2 Solo platform from Oxford Nanopore, recognized for its real-time capabilities, scalability, and improved accuracy in single-nucleotide sequencing, is an ideal fit for the rapid and cost-efficient identification of pathogens directly from clinical samples.

"We are pleased to launch this collaboration with Oxford Nanopore that integrates nanopore sequencing innovations with Day Zero Diagnostics' platform technologies to develop a first-of-its kind diagnostic solution for sepsis," said Jong Lee, CEO and co-founder of Day Zero Diagnostics. "Culture free, same day, organism identification and antimicrobial susceptibility profiling directly from native samples will be a game changer for infectious disease diagnostics, directly enabling early, targeted life-saving treatment for patients."

"We are excited to partner with Day Zero Diagnostics to bring the benefits of nanopore sequencing to fight bloodstream infections," said Gordon Sanghera, CEO of Oxford Nanopore Technologies. "Our hope is that the rapid results, high accuracy and accessibility of the Oxford Nanopore system, combined with DZD's expertise and workflow, will make it possible for more people to access a solution that's fast and effective in the fight against bloodstream infections."

Related Links:
Oxford Nanopore
Day Zero Diagnostics

Platinum Supplier
Xylazine Immunoassay Test
Xylazine ELISA
Gold Supplier
hCG Whole Blood Pregnancy Test
POCT Fluorescent Immunoassay Analyzer
H. pylori Test
QuickVue H. pylori Test

Print article


Clinical Chemistry

view channel
Image: A module with eight micro-devices, complete with microfluidic channels and drive motors (Photo courtesy of U.S Department of Energy)

Highly Sensitive pH Sensor to Aid Detection of Cancers and Vector-Borne Viruses

Understanding the acidity or alkalinity of substances through pH measurement is crucial in many fields, from environmental monitoring to healthcare product safety. In many cases, these measurements must... Read more

Molecular Diagnostics

view channel
Image: The PrismRA blood test helps target best treatments for patients with rheumatoid arthritis (Photo courtesy of Scipher Medicine)

Groundbreaking Rheumatoid Arthritis Blood Test Predicts Treatment Response

Rheumatoid arthritis (RA), an autoimmune disease affecting joints and other systems in the body, impacts millions globally. Typically, the initial biologic treatment involves anti-inflammatory drugs from... Read more


view channel
Image: The QScout hematology analyzer has received US FDA 510(k) clearance (Photo courtesy of Ad Astra Diagnostics)

First Rapid-Result Hematology Analyzer Reports Measures of Infection and Severity at POC

Sepsis, a critical medical condition that arises as an extreme response to infection, poses a significant health threat. It occurs when an infection triggers a widespread inflammatory response in the body.... Read more


view channel
Image: PointCheck is the world’s first device for non-invasive white cell monitoring (Photo courtesy of Leuko Labs)

World’s First Portable, Non-Invasive WBC Monitoring Device to Eliminate Need for Blood Draw

One of the toughest challenges for cancer patients undergoing chemotherapy is experiencing a low count of white blood cells, also known as neutropenia. These cells play a crucial role in warding off infections.... Read more


view channel
Image: AI methods used in satellite imaging can help researchers analyze tumor images (Photo courtesy of Karolinska Institutet)

AI Approach Combines Satellite Imaging and Ecology Techniques for Analysis of Tumor Tissue

Advancements in tumor imaging technology have significantly enhanced our ability to observe the minute details of tumors, but this also brings the challenge of interpreting vast amounts of data generated... Read more


view channel
Image: The acquisition significantly expands Medix Biochemica’s portfolio of IVD raw materials (Photo courtesy of ViroStat)

Medix Biochemica Acquires US-Based ViroStat to Expand Infectious Diseases Antibody Offering

Medix Biochemica (Espoo, Finland), a supplier of critical raw materials to the in vitro diagnostics (IVD) industry, has acquired ViroStat LLC (Portland, ME, USA), a provider of infectious disease antibodies... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.