We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Technopath Clinical Diagnostics

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

New Rapid COVID-19 Diagnostic Tests Use Innovative Techniques that Improve Accuracy Rivaling Gold Standard PCR Test

By LabMedica International staff writers
Posted on 16 Jun 2021
Print article
Illustration
Illustration
Researchers have developed two rapid diagnostic tests for COVID-19 that are nearly as accurate as the gold-standard test currently used in laboratories.

Unlike the gold standard test, which extracts RNA and uses it to amplify the DNA of the virus, these new tests developed by researchers at University of Maryland School of Medicine (Baltimore, MD, USA) can detect the presence of the virus in as little as five minutes using different methods. They do not require the extraction of the virus's RNA - which is both complicated and time consuming. Both tests are more reliable than the rapid antigen tests currently on the market, which detect the virus only in those with significantly high viral levels.

One test is a COVID-19 molecular diagnostic test, called Antisense that uses electrochemical sensing to detect the presence of the virus. The test detects the virus in a swab sample using an innovative technology called electrochemical sensing. It uses a unique dual-pronged molecular detection approach that integrates electrochemical sensing to rapidly detect the SARS-CoV-2 virus.

Similar to the Antisense test, the second rapid test also does not require the use of any advanced laboratory techniques, such as those commonly used to extract RNA, for analysis. It uses a simple assay containing plasmonic gold nanoparticles to detect a color change when the virus is present. Once a nasal swab or saliva sample is obtained from a patient, the nucleic acid (bits of genetic material) in the sample is amplified via a simple process that takes about 10 minutes. The test uses a highly specific molecule attached to the gold nanoparticles to detect a particular protein. This protein is part of the genetic sequence that is unique to the novel coronavirus. When the biosensor binds to the virus's gene sequence, the gold nanoparticles respond by turning the liquid reagent from purple to blue.

"These tests detect the presence of the virus within 5 to 10 minutes and rely on simple processes that can be performed with little lab training," said Dipanjan Pan, PhD, Professor of Diagnostic Radiology and Nuclear Medicine and Pediatrics at UMSOM. "These two newer tests are extremely sensitive and can detect the presence of the virus, even in those with low levels of the virus."

Related Links:
University of Maryland School of Medicine

Gold Supplier
COVID-19 RT-PCR Kit
CoviPath COVID-19 RT-PCR Kit
New
Viscometer Consumables
BV1 & BV200 Viscometer Consumables
New
Portable Electronic Pipette
MINI 96
New
Gold Supplier
Proficiency Assessment Software
CellaVision Proficiency Software

Print article

Channels

Molecular Diagnostics

view channel
Image: Primary angle closure glaucoma can cause permanent blindness if not treated quickly. A highly sensitive genetic test has been developed (Photo courtesy of Flinders University)

Highly Sensitive Genetic Test for Glaucoma Developed

In open-angle glaucoma, the angle in the eye where the iris meets the cornea is as wide and open as it should be, but the eye’s drainage canals become clogged over time, causing an increase in internal... Read more

Industry

view channel
Illustration

ELITechGroup Acquires Freezing Point Osmometry Provider GONOTEC

ELITechGroup (Puteaux, France) has acquired GONOTEC (Berlin, Germany), thus uniting two osmometry market leaders. The acquisition will also provides the industry with a full range of osmometry solutions... Read more
Copyright © 2000-2021 Globetech Media. All rights reserved.