We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Abbott Diagnostics- Hematology Division

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Maternal Multiomic Changes Could Predict Onset of Labor

By LabMedica International staff writers
Posted on 18 May 2021
Print article
Image: Multiomic prediction of time to labor from biomarkers in maternal blood (Photo courtesy of STELZER ET AL.)
Image: Multiomic prediction of time to labor from biomarkers in maternal blood (Photo courtesy of STELZER ET AL.)
Currently, predictions of when labor will start are imprecise and based on gestational age and an average pregnancy length of 40 weeks, even though the onset of labor between week 37 and 42 of pregnancy is considered normal. Having a better idea of when labor may arrive could help with planning and managing medical concerns like fetal lung maturation.

As pregnancy progresses toward labor, major transitions occur in fetomaternal immune, metabolic, and endocrine systems that culminate in birth. The comprehensive characterization of maternal biology that precedes labor is crucial to understanding these physiological transitions and identifying predictive biomarkers of delivery.

A large team of multidisciplinary scientists led by Stanford University School of Medicine (Palo Alto, CA, USA) followed more than 60 women toward the end of their pregnancies, collecting blood samples for metabolic, protein, and immune analysis. They collected a median of three blood samples from each participant within the 100 days preceding labor. Using untargeted mass spectrometry and an aptamer-based proteomic platform, the team tallied the levels of 3,529 metabolites and 1,317 proteins, while using a mass cytometry assay to gauge nearly 2,300 immune features over time.

The investigators pieces together a picture of the changes that occur in the two to four weeks prior to delivery. For instance, the levels of steroid hormones like progesterone and cortisol rose dramatically. At the same time, levels of factors involved in angiogenesis fell; a change they said could help weaken the connection between the uterus and the placenta, priming them for delivery.

Additional shifts affected the immune system. There was a rise in interleukin-1 receptor type 4 (IL-1R4) levels, which inhibits the inflammatory factor IL-33, suggesting that this change may tamp down inflammatory responses that might otherwise be triggered during labor. In addition, the increase in IL-1R4 levels could serve a labor-initiation signal. By feeding these changes into a model, the scientists developed a tool to predict when someone is about to go into labor. After training on their 53 cohort members, they tested their predictor on data from a further 10 women to find that it had high accuracy in predicting the time to labor. They further noted that the model could predict both preterm and term labor.

Virginia Winn, MD, an associate professor of obstetrics and gynecology and co-author of the study, said, “If we understand what's regulating labor, we might be able to do a better job of inducing labor.” The study was published on May 5, 2021 in the journal Science Translational Medicine.


Related Links:
Stanford University School of Medicine

New
Gold Supplier
COVID-19 Neutralization Antibody Test
iFlash-2019-nCoV Neutralization Antibody Test
New
COVID-19 Antigen Test
Instant-view PLUS COVID-19 Antigen Test
New
Gold Supplier
Nucleic Acid Extractor
MGISP-NE384
New
COVID-19 Portable Test Kit
VersaLab Portable

Print article
BIOHIT  Healthcare OY

Channels

Industry

view channel
Image: Quidel Receives Amended FDA Emergency Use Authorization for New AI-Powered Sofia Q Rapid Antigen Test Device (Photo courtesy of Quidel Corporation)

Quidel Receives Amended FDA Emergency Use Authorization for New AI-Powered Sofia Q Rapid Antigen Test Device

Quidel Corporation (San Diego, CA, USA) has received an amended Emergency Use Authorization (EUA) from the US Food and Drug Administration (FDA) allowing the company to market Sofia Q, its latest addition... Read more
Copyright © 2000-2021 Globetech Media. All rights reserved.