We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




新开发的POC测定能可靠鉴定血型

By LabMedica International staff writers
Posted on 14 Apr 2017
Print article
图片:根据观察区里是否存在蓝绿色确定A、B、AB和O型血(红色虚线框)。多重测定检验(C) ABO/Rh与 (D) 稀有血型系统(图片蒙第三军医大学惠赐)。
图片:根据观察区里是否存在蓝绿色确定A、B、AB和O型血(红色虚线框)。多重测定检验(C) ABO/Rh与 (D) 稀有血型系统(图片蒙第三军医大学惠赐)。
 快速准确地确定血型在生物科学和医学等多个学科中发挥至关重要的作用,尤其是对怀孕、输血和骨髓移植。

一种快速、准确、多用途的试纸验血方法日前开发成功,执行它无需特制的设备,从而为血型鉴定提供了一种更加经济实惠的方案。血型测定的原理是常用的pH指示剂染料与血液反应时的颜色变化。

重庆第三军医大学的医学家用溴甲酚绿试纸分析了3,550份静脉血样和指尖血样。一家诊断实验室用美国新泽西州Raritan市Ortho Clinical Diagnostics股份有限公司的BioVue凝胶卡测定辨识血型。这款试纸测定用固定的抗体和溴甲酚绿染料快速可靠地确定血型,不同的血液组分使染料变成不同颜色,目测即可获知结果。

30秒内可检测ABO抗原和五种主要的Rh血型抗原,取少量(100微升)全血做片上血浆分离,无需离心,两分钟内可同时进行正向和反向ABO血型鉴定。研究人员开发了一种机器学习方法,将对应于染色颜色变化的光谱图形归类,实现了可重复的自动分型。用最佳操作参数测定3,550份人类血样的血型,染料辅助的试纸测定表现出媲美经典凝胶卡测定的准确度和可重复性。如果投入组装线和低成本生产,这项研究提出的方法也许能发展成一套经济实惠、稳定的血型鉴定通用平台。

该研究的论文发表于2017年3月15日的《科学》杂志《转化医学》分册。作者总结说,这款测定产品不仅为血型鉴定提供了新策略,还可在时间紧迫、资源有限的情况下使用,如战场、偏远地区以及急诊过程。该研究提出的血型测定方法加强并简化了工作流,经过进一步开发可成为高度紧凑的全自动平台,效率极高且经济,使大规模制造成为可能。

第三军医大学
Ortho Clinical Diagnostics 



Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Magnetic Bead Separation Modules
MAG and HEATMAG
Anti-Cyclic Citrullinated Peptide Test
GPP-100 Anti-CCP Kit
New
Gold Member
TORCH Panel Rapid Test
Rapid TORCH Panel Test

Print article

Channels

Clinical Chemistry

view channel
Image: The 3D printed miniature ionizer is a key component of a mass spectrometer (Photo courtesy of MIT)

3D Printed Point-Of-Care Mass Spectrometer Outperforms State-Of-The-Art Models

Mass spectrometry is a precise technique for identifying the chemical components of a sample and has significant potential for monitoring chronic illness health states, such as measuring hormone levels... Read more

Molecular Diagnostics

view channel
Image: A blood test could predict lung cancer risk more accurately and reduce the number of required scans (Photo courtesy of 123RF)

Blood Test Accurately Predicts Lung Cancer Risk and Reduces Need for Scans

Lung cancer is extremely hard to detect early due to the limitations of current screening technologies, which are costly, sometimes inaccurate, and less commonly endorsed by healthcare professionals compared... Read more

Hematology

view channel
Image: The CAPILLARYS 3 DBS devices have received U.S. FDA 510(k) clearance (Photo courtesy of Sebia)

Next Generation Instrument Screens for Hemoglobin Disorders in Newborns

Hemoglobinopathies, the most widespread inherited conditions globally, affect about 7% of the population as carriers, with 2.7% of newborns being born with these conditions. The spectrum of clinical manifestations... Read more

Immunology

view channel
Image: Exosomes can be a promising biomarker for cellular rejection after organ transplant (Photo courtesy of Nicolas Primola/Shutterstock)

Diagnostic Blood Test for Cellular Rejection after Organ Transplant Could Replace Surgical Biopsies

Transplanted organs constantly face the risk of being rejected by the recipient's immune system which differentiates self from non-self using T cells and B cells. T cells are commonly associated with acute... Read more

Pathology

view channel
Image: Comparison of traditional histopathology imaging vs. PARS raw data (Photo courtesy of University of Waterloo)

AI-Powered Digital Imaging System to Revolutionize Cancer Diagnosis

The process of biopsy is important for confirming the presence of cancer. In the conventional histopathology technique, tissue is excised, sliced, stained, mounted on slides, and examined under a microscope... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.