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Pathology

Image: De novo prediction of cancer-associated T cell receptors for noninvasive cancer detection (Photo courtesy of UT Southwestern Medical Center).

Cancer-Associated T Cell Receptors Evaluated for Malignancy Detection

A key goal in oncology is diagnosing cancer early, when it is more treatable. Despite decades of progress, early diagnosis of asymptomatic patients remains a major challenge. Most methods for this involve detecting cancer cells, but a different approach, focused on the body’s immune response. More...
31 Aug 2020
Image: The compact Chromium Controller advanced microfluidics platform enables high-throughput analysis. Each single use chip processes up to eight samples in parallel in less than 20 minutes. (Photo courtesy of 10×Genomics).

Single-Cell Analysis Provides New Insights into Mitochondrial Diseases

Mitochondrial diseases result from failure of mitochondria, specialized compartments within cells that contain their own DNA and produce the energy needed to sustain life. Some of the most challenging mitochondrial disorders arise from mutations in mitochondrial DNA (mtDNA), a high-copy-number genome that is maternally inherited. More...
24 Aug 2020
DIASOURCE (A Biovendor Company)
The Gallios 10-color/3-laser flow cytometer (Photo courtesy of Beckman Coulter).

Prostate Cancer Identified By Profiling Immune Cell Subsets

With an estimated 1.8 million new cases in 2018 alone, prostate cancer is the fourth most common cancer in the world. Diagnosing the disease early increases the chances of survival, but this cancer remains difficult to detect. More...
19 Aug 2020
Signatera assays are the first circulating tumor DNA (ctDNA) tests custom-built for each patient based on the unique mutations in an individual patient’s tumor (Photo courtesy of Natera Inc).

Circulating tumor DNA Test Predicts Immunotherapy Response

 Immunotherapy is a type of cancer treatment that helps the immune system fight cancer. Although some cancer patients derive dramatic and sustained benefit from immunotherapy, most cancer patients do not. More...
19 Aug 2020
In situ expression of chemokines eotaxin, IL-8, and MIP-1α in glomerular and tubulointerstitial compartments in patients with diabetic nephropathy (DN) and control group (Photo courtesy of Federal University of Triângulo Mineiro).

Renal Expression of Immunomodulators in Diabetic Nephropathy

Diabetic nephropathy (DN) is a chronic microvascular complication that affects about 20% to 30% of patients with type 2 diabetes mellitus (T2DM). It is considered the leading cause of end-stage renal failure requiring renal replacement therapy. More...
12 Aug 2020
Image: The Xevo mass spectrometer with an Acquity ultra high performance chromatography system (Photo courtesy of Waters Corporation).

Simple Urine Test Significantly Improves Detection of Adrenal Cancer

Prognosis for patients discovered to have an adrenal cortical carcinoma (ACC), a cancerous adrenal mass, is poor, and a cure is only achievable through early detection and surgery. The incidental discovery of an adrenal mass often triggers additional scans to determine whether the mass is cancerous. More...
06 Aug 2020
Image: The NovaSeq 6000 Sequencing System offers high-throughput sequencing across a broad range of applications (Photo courtesy of Illumina).

Somatic Evolution Identified in Non-Neoplastic IBD-Affected Colon

Inflammatory bowel disease (IBD) is a debilitating disease characterized by repeated flares of intestinal inflammation. The two major subtypes of IBD, Crohn’s disease (CD) and ulcerative colitis (UC) are distinguished by the location, continuity, and nature of the inflammatory lesions. More...
06 Aug 2020
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Serological Pipets
INTEGRA Serological Pipets
3-Part Differential Hematology Analyzer
Swelab Alfa Plus Sampler
New
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Pipette Management Software
VIALINK
New
Host Response Immunoassay Test
MeMed BV


The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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