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Pathology

Image: Claire Carter, Ph.D., an expert in MALDI, led the new research (Photo courtesy of CDI)

Advanced Mass Spectrometry Could Provide Microscopic Clues to Beating Deadly Brain Tumors

Glioblastoma is one of the most difficult cancers, let alone diseases, to treat. Now, scientists have discovered that a critical new pathway to treating brain tumor might be found in the complex diversity within the tumor tissue. More...
01 Nov 2022
Image: Virtual HER2 staining of unlabeled breast tissue sections using deep learning (Photo courtesy of UCLA)

AI-Based Staining Technique as Accurate as Traditional Histopathology in Assessing Breast Cancer Biomarker

Upon breast cancer diagnosis, the testing of HER2 – a protein that promotes cancer cell growth, is routinely carried out to help assess the cancer prognosis and make HER2-directed treatment plans. Researchers have now developed a computational staining approach powered by deep learning, which performs the HER2 staining without requiring any chemicals. More...
28 Oct 2022
Image: Agilent Technologies 2100 Bioanalyzer and DNA chip (Photo courtesy of GMI)

Super-Enhancer Induces Oncogenic Driver in Colorectal Carcinoma

The etiology of super-enhancer (SE) reprogramming in cancer is incompletely understood, but is widely attributed to cancer cell-intrinsic genomic alterations. Non-coding SE can become focally amplified in multiple malignancies. More...
24 Oct 2022
Image: The BenchMark ULTRA system is Roche Tissue Diagnostics’ most innovative, fully-automated immunohistochemistry and in situ hybridization slide staining system (Photo courtesy of Roche Group)

Gene Expression Profiling of Mucinous Ovarian Tumors Identifies Prognosis Markers

Advanced stage mucinous ovarian tumors have poor chemotherapy response and prognosis and lack biomarkers to aid Stage I adjuvant treatment. Differentiating primary mucinous ovarian carcinoma (MOC) from gastrointestinal (GI) metastases to the ovary is also challenging due to phenotypic similarities. More...
18 Oct 2022
Image: The T100 thermal cycler is a small thermal cycler offering a comprehensive set of convenient features in a small footprint (Photo courtesy of Bio-Rad)

Link Identified Between Mitochondria and Pancreatic Cancer Risk

Tumors invariably rewire their metabolism to promote cellular plasticity, adapt to ever-changing nutrient availability and acquire traits of aggressive disease, including metastatic competence. Cancer metabolism has long been equated with the preferential utilization of glycolysis by tumor cells even when oxygen is present. More...
18 Oct 2022
Image: TissueCypher is a precision medicine test designed to predict progression to HGD or EAC in patients with BE (Photo courtesy of Castle Biosciences)

World’s First Precision Medicine Test Predicts Progression to Esophageal Cancer in Patients with Barrett’s Esophagus

A new study has shown that a precision medicine test can significantly improve a physician’s accuracy in assessing the risk of progression to high-grade dysplasia (HGD) or EAC in patients diagnosed with BE. More...
17 Oct 2022
Image: New model acts as search engine for large databases of pathology images (Photo courtesy of Brigham and Women’s Hospital)

Self-Teaching AI Algorithm Uses Pathology Images to Diagnose Rare Diseases

Researchers have developed a deep learning algorithm that can teach itself to learn features which can then be used to find similar cases in large pathology image repositories and has many potential applications, including identifying rare diseases. More...
11 Oct 2022
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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