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Pathology

Image: Bone marrow aspirate from a child with a mediastinal tumor shows an invasion with neuroblastoma cells and characteristic images of neuropile threads (Photo courtesy of Mohammed Bensalah, MD, Amina Lyagoubi, and Rachid Seddik)

Single-Cell Transcriptomic Analysis Traces Neuroblastomas to Developing Adrenal Neuroblasts

Neuroblastoma is the most common cancer in infants and the third-most common cancer in children after leukemia and brain cancer. Approximately one in every 7,000 children is affected at some time and about 90% of cases occur in children less than five years old, and it is rare in adults. More...
07 Apr 2021
Image: The MassARRAY Dx Analyzer is a benchtop multiplex genetic analyzer that simplifies the complex clinical genetics environment with easy-to-interpret data, flexible biomarker detection and robust performance (Photo courtesy of Agena Biosciences)

Whole-Genome Sequencing Aids Rare Disease Diagnosis

Diagnostics of genetic diseases are currently being revolutionized, due to breakthroughs in sequencing technology and data analysis. The potential to transform clinical medicine using genomics is high, especially within the realm of rare diseases. More...
01 Apr 2021
Image: Elecsys BRAHMS PCT Assay measures procalcitonin in human serum (Photo courtesy of Roche Diagnostics).

Calcitonin and Procalcitonin Immunoassays Investigated for Medullary Thyroid Carcinoma

Medullary thyroid carcinoma (MTC) is caused by a malignant transformation in the parafollicular C-cells of the thyroid, where calcitonin (CT) is released. Nowadays, CT is the main tumor marker used in the diagnosis and follow-up of MTC patients. More...
23 Mar 2021
Image: The BD LSRFortessa X-20 cell analyzer (Photo courtesy of BD Biosciences)

Immune Cells in Cerebrospinal Fluid Predict Response to Immunotherapy

Immune checkpoint inhibitors including anti-PD1, anti-PD-L1, and anti-CTLA4, have shown significant clinical benefits in patients with progressive or metastatic solid tumors, including some brain metastasis. Notably, these immune-based therapies have improved outcomes for some of those suffering from lung cancer and melanoma. More...
22 Mar 2021
Image: Histopathology of pancreatoblastoma showing a large squamoid nest surrounded by sheet of bland monomorphic cells. Many of the squamous cell nuclei are optically clear due to accumulation of biotin (Photo courtesy of Dharam Ramnani, MD).

Pediatric Pancreatic Cancer Diagnosed From cfDNA Fragments in Urine

Although rare, pancreatoblastoma is the most common pancreatic tumor of young children. Carcinoma of acinar cell origin has rarely been reported in older children. Ductal adenocarcinoma and its many variants are the most common pancreatic tumors in adults, but these are exceedingly rare in children. More...
17 Mar 2021
Image: In-vitro misfolded α-synuclein amplification by real-time quaking-induced conversion (Photo courtesy of University of Edinburgh).

CSF Biomarker Flags Parkinson's Pathology Much Earlier

Isolated rapid-eye-movement (REM) sleep behavior disorder (IRBD) can be part of the prodromal stage of the α-synucleinopathies Parkinson's disease and dementia with Lewy bodies years before clinical symptoms appear. More...
16 Mar 2021
Image: Histopathology of Lewy bodies in the midbrain. A Lewy body in a melanized neuron from the substantia nigra. The Lewy body is the spherical body indicated by an arrow (Photo courtesy of Dr. Susan Daniel).

Five Genes Help Predict Lewy Body Dementia

Lewy body dementia usually affects people over 65 years old. Early signs of the disease include hallucinations, mood swings, and problems with thinking, movements, and sleep. Patients who initially have cognitive and behavioral problems are usually diagnosed as having dementia with Lewy bodies, but are sometimes mistakenly diagnosed with Alzheimer’s disease. More...
10 Mar 2021
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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