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Pathology

Image: A) NDUFS1 immunohistochemistry staining of prostate cancer (PCa) tissue microarray (TMA) samples and B) ATP5O immunohistochemistry staining of PCa TMA samples. Staining intensity as per number. Scale bar = 100 µm (Photo courtesy of Medical University of Vienna)

Novel Protein Biomarkers Identified for Prostate Cancer Aggressiveness

Prostate cancer is the most commonly diagnosed cancer in men and is among the top five causes of cancer-related death. In most cases, prostate cancer can be successfully treated but there is a group of patients who suffer an aggressive course and often fatal outcome. More...
05 Jan 2022
Image: Normal or Near Normal Aminotransferase Levels Found in Patients with Alcoholic Cirrhosis (Photo courtesy of Biology Dictionary)

Near Normal Aminotransferase Levels Reported in Alcoholic Cirrhosis Patients

Alcoholic cirrhosis affects around 1 in 400 adults in the USA. It is an advanced form of liver disease, which occurs when chronic ethanol use leads to inflammation and cirrhosis or scarring of the liver. Less than 50% of people diagnosed with advanced liver disease due to cirrhosis survive for one year, and so early diagnosis is crucial. More...
30 Dec 2021
Image: A colored scanning electron micrograph (SEM) of a breast cancer cell (Photo courtesy of Case Western Reserve University School)

Biomarker FR+CTC Explored for Breast Cancer Diagnosis

The prognosis of breast cancer is dramatically improved owing to progress on the early diagnosis and effective therapy, and the survivor number is higher than any other types of cancers. However, the number of new breast cancer cases reached 2.26 million in 2020, accounted for 11.7% of all new tumor cases. More...
30 Dec 2021
Image: Blood film from a patient with Monoclonal B-cell lymphocytosis. The circulating atypical lymphocytes are mature with a small rim of basophilic cytoplasm. Monoclonal population of B cells in the blood is less than 5 ×109/L (Photo courtesy of Elizabeth Courville, MD)

Tissue Counterpart to Monoclonal B-Cell Lymphocytosis Characterized

Monoclonal B-cell lymphocytosis (MBL) was initially proposed to recognize patients with a monotypic B-cell population identified by peripheral blood (PB) flow cytometry (FC) that did not meet numerical criteria for chronic lymphocytic leukemia (CLL). More...
27 Dec 2021
Image: A screenshot of a volume rendering of glands in two 3D biopsy samples from prostates (yellow: the outer walls of the gland; red: the fluid-filled space inside the gland). The cancer sample (top) shows smaller and more densely packed glands compared to the benign tissue sample (bottom) (Photo courtesy of Xie et al./Cancer Research)

3D Imaging Method Determines Prostate Cancer Aggressiveness

Prostate cancer is the most common cancer for men and, for men in the USA, and it is the second leading cause of death. Prostate cancer treatment planning is largely dependent upon examination of core-needle biopsies. The microscopic architecture of the prostate glands forms the basis for prognostic grading by pathologists. More...
23 Dec 2021
Image: Histopathology of a typical neuroblastoma with rosette formation (Photo courtesy of Dr. Mark Applebaum, MD)

Intratumor Heterogeneity Analyzed in Neuroblastoma

Neuroblastoma is the most common solid pediatric tumour, accounting for 15% of cancer-related deaths in early childhood and especially for patients directly diagnosed with high-risk neuroblastoma have a poor prognosis. More...
22 Dec 2021
Image: The NovaSeq 6000 offers deeper and broader coverage through advanced applications for a comprehensive view of the genome and unlocks the full spectrum of genetic variation and biological function with high-throughput sequencing (Photo courtesy of Illumina)

Genomic Screening Can Identify Risk for Amyloid Cardiomyopathy

Transthyretin amyloidosis (ATTR) a is a rare, progressive disease characterized by the abnormal buildup of amyloid deposits composed of misfolded transthyretin protein in the body’s organs and tissues. ATTR can be hereditary and lead to a spectrum of other diseases and conditions, including cardiomyopathy, a common precursor to heart failure. More...
15 Dec 2021
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.

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