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Hematology

Image: A peripheral blood film from a patient with plasma cell leukemia showing four plasma cells and rouleaux formation of erythrocytes (Photo courtesy of the Tsuyako Saito).

New Definition for Plasma Cell Leukemia Proposed

Plasma cell leukemia (PCL) is an uncommon but aggressive malignancy that accounts for 1% to 2% of all plasma cell dyscrasias. PCL has been defined as the presence of ≥ 20% circulating plasma cells (CPCs) on conventional white blood cell differential count and an absolute plasma cell count of ≥ 2 × 109/L in the peripheral blood. More...
09 Jan 2019
Image: Howell-Jolly body–like inclusion within neutrophil (arrow). It appears as a completely detached and densely basophilic inclusion in the cytoplasm of neutrophil. Photos were taken from different cases (Photo courtesy of University of Texas Health Science Center at Houston).

Howell-Jolly Body-Like Inclusions Correlated with Myelodysplastic Syndrome

Howell-Jolly body–like inclusions have been previously associated with patients who are human immunodeficiency virus (HIV) infected, taking antiviral medications, and immunosuppressed. These inclusions appear in neutrophils and resemble Howell-Jolly bodies of normoblasts in abnormal erythropoiesis. More...
07 Jan 2019
Image: Bone marrow aspirate smear from a patient with acute lymphoblastic leukemia reveals increased blasts which are small to medium in size with high nuclear-to-cytoplasmic ratios, round to irregular nuclei, smooth chromatin, and scant basophilic agranular cytoplasm (Photo courtesy of Karen M. Chisholm MD, PhD).

Genetic Marker Predicts Early Relapse in Pediatric ALL

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer; however, treatment has improved dramatically due to the ability to stratify patients into groups based on risk factors and genetic analysis. More...
24 Dec 2018
Image: Blood smears from normal and macrocytic anemia patients (Photo courtesy of Myrtle Porter).

Macrocytic Anemia Associated with HBV Liver Impairment Severity

Cirrhosis is an end-stage disease that invariably leads to death and it is the 14th most common cause of death in adults worldwide and results in 1.03 million deaths per year. Chronic infection with hepatitis B virus (HBV) is one of the major causes of cirrhosis and 30% of deaths are attributable to HBV. More...
19 Dec 2018
Image: The CellTiter-Glo 3D cell viability assay (Photo courtesy of Promega).

Potential Screening for Tailoring Treatment of AML

Acute Myeloid Leukemia (AML) is a serious disorder of certain blood-forming cells. In this disease, certain early precursor cells in the bone marrow that usually develop into white blood cells do not mature properly. They remain frozen as primitive cells called blasts, unable to further differentiate and mature. More...
17 Dec 2018
Image: Tumor heterogeneity, clonal evolution and therapy resistance was revealed using single cell profiling of multiple myeloma patients (Photo courtesy of Weizmann Institute of Science).

Unique Genetic Makeup of Myeloma Tumor Cells Profiled

Multiple myeloma is the second-most common type of blood cancer. Multiple myeloma occurs when plasma cells in the bone marrow, the cells that produce antibodies, proliferate out of control and lead to various type of organ failure and death. More...
17 Dec 2018
Image: The CareStart HRP2 rapid diagnostic test for Plasmodium falciparum malaria (Photo courtesy of Access Bio).

Plasmodium vivax Isolated in Duffy Negative Individuals

Malaria in Nigeria is principally due to Plasmodium falciparum and, to a lesser extent to P. malariae and P. ovale. P. vivax is thought to be absent in Nigeria in particular and sub-Saharan Africa in general, due to the near fixation of the Duffy negative gene in this population. More...
12 Dec 2018
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.

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