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Hematology

Image: Bone marrow smear in T-cell acute lymphoblastic leukemia shows pleomorphic blasts cells and smear cells. Two of the blasts have a hand-mirror conformation (arrows) (Photo courtesy of Ke Xu, MD).

Positive Lymphocyte Gene Rearrangement Evaluated for Hematologic Malignancies

The diagnosis of a lymphoid malignancy requires the establishment of monoclonality of a lymphocyte population through morphologic assessment and laboratory testing, such as flow cytometry, immunohistochemistry, and cytogenetic analysis. More...
08 Sep 2020
Image: A blood film with a normal mature lymphocyte with a single large nucleus is seen on the left, compared to two segmented neutrophils on the right with multiple nuclear lobes. The lymphocytes are decreased in comorbid diabetes and COVID-19 patients (Photo courtesy of Ed Reschke).

Lymphocyte Count Correlated to Comorbid Diabetes and COVID-19

The coronavirus disease (COVID-19) that erupted in China since December 2019 and has gradually spread throughout the world. At present, it has caused tens of thousands of deaths, and the efficacy of certain antiviral drugs is still under review. More...
03 Sep 2020
Image: Higher prevalence of clonal hematopoiesis found in the blood and bone marrow of older healthy volunteers (Photo courtesy of Sorbonne University).

Clonal Hematopoiesis Prevalence Determined in Healthy Donors

Clonal hematopoiesis of indeterminate potential (CHIP) is defined as the presence of a clone at more than 2% of variant allele frequency (VAF) in peripheral blood (PB) of individuals with no evidence of hematologic disease. More...
02 Sep 2020
Image: Photomicrograph of Hodgkin lymphoma (HL), from a fine needle aspiration of a lymph node, which shows a mixture of cells common in HL: Eosinophils, Reed-Sternberg cells, Plasma cells, and Histocytes (Photo courtesy of Nephron).

Hodgkin Lymphoma Therapy Response Linked to T-Cell Receptor Repertoire

Hodgkin lymphoma (HL) is a type of lymphoma in which cancer originates from a specific type of white blood cells called lymphocytes. Symptoms may include fever, night sweats, and weight loss. Often there will be non-painful enlarged lymph nodes in the neck, under the arm, or in the groin. More...
27 Aug 2020
Image: Schematic diagram of the OvCa-Chip microsystem that recreates vascular endothelium–mediated platelet extravasation in ovarian cancer (Photo courtesy of Texas A&M College of Engineering).

Microfluidic Device Explores Ovarian Cancer Interactions

In many cancers, platelet interactions with circulating tumor cells and their role in metastasis have been studied extensively. In ovarian cancer, platelet extravasation into the tumor and resulting metastasis is thought to be regulated mostly by the vascular endothelium. More...
26 Aug 2020
Image: iCHROMA is an automatic or semiautomatic in-vitro diagnostic device that measures via cartridges the concentration of analytes, contained in blood, urine, or other samples, in quantitative or semi-quantitative ways (Photo courtesy of Boditech Med Inc).

Biomarkers Evaluated for Severity of Diabetic Kidney Disease

Type 2 diabetic mellitus (T2DM) is a chronic metabolic disorder with multiple complications, including diabetic retinopathy, diabetic neuropathy, diabetic kidney disease (DKD) as well as cardiovascular diseases. T2DM is related to an exacerbated systematic inflammation. More...
24 Aug 2020
The TriVersa NanoMate LESA uses chip-based electrospray ionization technology that combines the benefits of liquid chromatography, mass spectrometry, chip-based infusion, fraction collection, and direct surface analysis into one integrated ion source platform (Photo courtesy of Advion BioSciences).

Nanoparticle System Captures Heart-Disease Biomarker From Blood

Physicians currently use an antibody-based test called enzyme-linked immunosorbent assay (ELISA) to help diagnose heart attacks based on elevated levels of cardiac troponin I (cTnI) in the patient's blood sample. While the ELISA test is sensitive, patients can have high levels of cTnI in the blood without having heart disease, which can lead to expensive and unnecessary treatments for patients. More...
20 Aug 2020
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.
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