We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
PURITAN MEDICAL

BECKMAN COULTER, INC.

Beckman Coulter develops, manufactures and markets laboratory systems, reagents, centrifugation, lab automation, elec... read more Featured Products: More products

Download Mobile App




Soluble Transferrin Receptor Investigated in Iron Deficiency Anemia

By LabMedica International staff writers
Posted on 25 May 2020
Print article
Image: The UniCel DxI 800 Access Immunoassay System (Photo courtesy of Beckman Coulter).
Image: The UniCel DxI 800 Access Immunoassay System (Photo courtesy of Beckman Coulter).
Anemia is a global public health problem and approximately 30% of the world's population suffered from anemia, with children and pregnant women being the most affected. Microcytic hypochromic anemia is a common type of anemia, and iron deficiency anemia (IDA) is the most common manifestation of this anemia.

The current gold standard for an IDA diagnosis is iron staining of a bone marrow smear. Transferrin receptor (TfR) is a transmembrane glycoprotein. Iron is transported by binding to specific TfR‐transferrin complex and thereby released into cells. Through proteolysis, TfR produces soluble transferrin receptor (sTfR) in the serum, whose concentration is proportional to the TfR concentration.

Laboratory medical scientists at the Peking Union Medical College Hospital (Beijing, China) enrolled 436 subjects from March 2014 to August 2015. Among these, 118 were patients with IDA, 161 were patients with anemia of chronic disease (ACD), 60 were patients with chronic diseases with iron deficiency anemia (CIDA), and 97 were apparently healthy subjects (HS).

The scientists used the DXI 800 automatic immunoassay analyzer (Beckman Coulter, Brea, CA, USA), the Cobas c702 automatic biochemistry analyzer (Roche Diagnostics, Risch-Rotkreuz, Switzerland), and the Siemens BNII special protein analyzer (Siemens Healthineers, Erlangen, Germany) with their corresponding sTfR reagents and calibrators. The sTfR concentrations in two groups of patient specimens with high‐level and low‐level sTfR concentrations and in quality control materials were measured four times a day for five consecutive days to evaluate the precision of the three methods.

The investigators reported that for the diagnosis of IDA, the cutoff points of sTfR measured by the chemiluminescent, immunoturbidimetric, and immunonephelometric assays were 2.91, 6.70, and 2.48 mg/L, respectively. The corresponding sensitivities were 85.59%, 85.59%, and 85.59%, the specificities were 91.47%, 90.31%, and 90.70%, and area under the curve was 0.943, 0.944, and 0.936, respectively. The sTfR concentrations measured by the different methods were significantly higher in the IDA and CIDA groups than in the other two groups.

The authors concluded that the different sTfR measurement methods showed similar diagnostic value in diagnosing iron deficiency and identifying whether ACD was combined with iron deficiency. However, there were large differences in the measurement results obtained with the different methods, and their cutoff points also varied. Therefore, when sTfR is used in the course of clinical diagnosis and treatment and to establish relevant diagnostic criteria and guidelines, clinicians should pay attention to the differences in the results between different measurement methods. The study was first published on April 22, 2020 in the Journal of Clinical Laboratory Analysis.


Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
HLX
Anti-Cyclic Citrullinated Peptide Test
GPP-100 Anti-CCP Kit
New
Gold Member
Systemic Autoimmune Testing Assay
BioPlex 2200 ANA Screen with MDSS

Print article

Channels

Clinical Chemistry

view channel
Image: Reaching speeds up to 6,000 RPM, this centrifuge forms the basis for a new type of inexpensive, POC biomedical test (Photo courtesy of Duke University)

POC Biomedical Test Spins Water Droplet Using Sound Waves for Cancer Detection

Exosomes, tiny cellular bioparticles carrying a specific set of proteins, lipids, and genetic materials, play a crucial role in cell communication and hold promise for non-invasive diagnostics.... Read more

Molecular Diagnostics

view channel
Image: The study showed the blood-based cancer screening test detects 83% of people with colorectal cancer with specificity of 90% (Photo courtesy of Guardant Health)

Blood Test Shows 83% Accuracy for Detecting Colorectal Cancer

Colorectal cancer is the second biggest cause of cancer deaths among adults in the U.S., with forecasts suggesting 53,010 people might die from it in 2024. While fewer older adults are dying from this... Read more

Microbiology

view channel
Image: The new platform is designed to perform blood-based diagnoses of nontuberculosis mycobacteria (Photo courtesy of 123RF)

New Blood Test Cuts Diagnosis Time for Nontuberculous Mycobacteria Infections from Months to Hours

Breathing in nontuberculous mycobacteria (NTM) is a common experience for many people. These bacteria are present in water systems, soil, and dust all over the world and usually don't cause any problems.... Read more

Industry

view channel
Image: These new assays are being developed for use on the recently introduced DxI 9000 Immunoassay Analyzer (Photo courtesy of Beckman Coulter)

Beckman Coulter and Fujirebio Expand Partnership on Neurodegenerative Disease Diagnostics

Beckman Coulter Diagnostics (Brea, CA, USA) and Fujirebio Diagnostics (Tokyo, Japan) have expanded their partnership focused on the development, manufacturing and clinical adoption of neurodegenerative... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.