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Clinical Chemistry

Image: The Phadia 200 instrument is small enough to fit on a benchtop, and yet capable of running the complete menu of more than 700 different ImmunoCAP and EliA tests to aid in the diagnosis of allergy and autoimmune diseases (Photo courtesy of Thermo Fisher Scientific)

Circulating Calprotectin as Biomarker in Neutrophil-Related Inflammation

Calprotectin (CLP) acts as an endogenous ligand of different cell-surface proteins like Toll-like receptor 4 and receptor of advanced glycation end-products facilitating a local proinflammatory effect. CLP is mostly secreted through an active, calcium-dependent Protein Kinase C (PKC) pathway, next to the passive leakage from necrotic cells and release in neutrophil extracellular traps (NET). More...
15 Apr 2021
Image: Histology comparison of airway features in (A) a healthy individual and (B) in a patient with chronic obstructive pulmonary disease where airways are narrowed by infiltration of inflammatory cells, mucosal hyperplasia, and deposition of connective tissue in the peribronchiolar space (Photo courtesy of University of Leuven)

Coagulation Dysfunction and Infection Evaluated in Patients with AECOPD

Chronic obstructive pulmonary disease (COPD) is one of the common chronic airway obstructive diseases, characterized by persistent respiratory symptoms and airflow limitation. In acute exacerbation stage (AECOPD), patients developed respiratory failure often have circulatory and coagulation dysfunction, which was considered the cause of thrombosis events in the patients. More...
14 Apr 2021
Image: Elevated liver enzymes are associated with incident diabetes in US Hispanic/Latino adults (Photo courtesy of Judy George, BA, MBA)

High Liver Enzymes Increase Diabetes Risk for Hispanic Adults

Non‐alcoholic fatty liver disease (NAFLD) has been associated with increased risk of incident diabetes, but such evidence is lacking in the Hispanic/Latino population, which has high prevalence of obesity and NAFLD. More...
08 Apr 2021
Image: The Diazyme Lipoprotein A assay kit is for the in vitro quantitative determination of Lp(a) concentration in human serum or plasma on Clinical Chemistry Systems (Photo courtesy of Diazyme)

Performance of Five Lipoprotein(a) Immunoassays Evaluated

Increased serum Lipoprotein(a) [Lp(a)] is considered an independent, inherited risk factor for atherosclerotic cardiovascular disease (ASCVD), including myocardial infarction and stroke. This risk is believed to be due to pro-atherogenic, pro-inflammatory, and pro-thrombotic properties of the Lp(a) particle More...
06 Apr 2021
Image: The ERMA PCE-210N fully automatic cell counter (Photo courtesy of ERMA)

Flow-Cytometric Expression of Endoglin Assessed in B-Acute Lymphoblastic Leukemia

Acute lymphoblastic leukemia (ALL) is a malignant disorder representing clonal expansion and arrest of maturation of lymphoid progenitor cells in the bone marrow, blood, and extramedullary sites. The incidence of ALL generally follows a bimodal distribution, with its first peak occurring in childhood and the second around the age of 50. More...
01 Apr 2021
Image: The Vantera Clinical Analyzer based on nuclear magnetic resonance (Photo courtesy of Liposcience)

NMR-Based Method Measures Circulating Blood Citrate Levels

Recent studies show that citrate is involved in several biological processes such as inflammation, cancer, insulin secretion, acetylation of histones, neurological development and hydroxylglutaric aciduria, indicating that it has functions beyond energy regulation. More...
31 Mar 2021
Image: A blood test for Vitamin D showed that African-Americans individuals with low Vitamin D were more at risk from COVID-19 (Photo courtesy of Getty Images)

Vitamin D Levels Tied to COVID-19 Risk for African-Americans

Vitamin D has diverse physiological effects, including on calcium regulation, bone density, and immune function. Deficient levels, typically defined as 25-hydroxyvitamin D (also known as calcifediol) level less than 20 ng/mL are common, especially in African-Americans individuals. More...
29 Mar 2021
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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