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Clinical Chemistry

Image: White blood cells in the urine of a patient with bacteriuria pyuria, a urinary tract infection. The cells have lobed nuclei and refractile cytoplasmic granules (Photo courtesy of University of Utah Medical School).

White Blood Cell Help Define Pediatric Urinary Tract Infections

Urinary tract infections account for up to 7% of fevers in children up to 24 months old and are a common driver of hospital emergency room visits. These bacterial infections in infants and toddlers can be difficult to diagnose because their symptoms are similar to other fever-causing conditions. More...
25 Mar 2021
Image: Elecsys BRAHMS PCT Assay measures procalcitonin in human serum (Photo courtesy of Roche Diagnostics).

Calcitonin and Procalcitonin Immunoassays Investigated for Medullary Thyroid Carcinoma

Medullary thyroid carcinoma (MTC) is caused by a malignant transformation in the parafollicular C-cells of the thyroid, where calcitonin (CT) is released. Nowadays, CT is the main tumor marker used in the diagnosis and follow-up of MTC patients. More...
23 Mar 2021
Image: The Mindray CL-2000i Chemiluminescence Immunoassay System (Photo courtesy of Mindray Bio‐Medical Electronics).

Chemiluminescence Anti‐Müllerian Hormone Assay Performance Characterized

Müllerian hormone (AMH), a dimeric glycoprotein hormone, is a member of the transforming growth factor‐β superfamily that plays a predominant role in male and female sexual differentiation. More...
18 Mar 2021
Image: The Elecsys high-sensitivity cardiac troponin T (hs-cTnT) assay: as immunological method for the in vitro quantification of cardiac troponin T in human serum and plasma (Photo courtesy of Roche Diagnostics).

Cardiac Troponins Assessed for Acute Heart Failure

Heart failure (HF) is a clinical syndrome characterized by dyspnea, peripheral edema and fatigue. Diagnosing HF can be difficult due to overlapping symptoms with other conditions, and the phenotype of HF varies due to a broad spectrum of underlying pathophysiology. More...
17 Mar 2021
Image: In-vitro misfolded α-synuclein amplification by real-time quaking-induced conversion (Photo courtesy of University of Edinburgh).

CSF Biomarker Flags Parkinson's Pathology Much Earlier

Isolated rapid-eye-movement (REM) sleep behavior disorder (IRBD) can be part of the prodromal stage of the α-synucleinopathies Parkinson's disease and dementia with Lewy bodies years before clinical symptoms appear. More...
16 Mar 2021
Image: The principle of SOMAscan Assay that allows for the simultaneous detection of 1,300 human proteins using SOMAmer (Slow Off-rate Modified Aptamer) protein-binding reagents (Photo courtesy of SomaLogic).

Blood Biomarker Discovered for Autism Spectrum Disorder

Autism spectrum disorder (ASD), a heterogeneous neurodevelopmental disorder, is characterized by deficits in social communication and social interaction, with restricted, repetitive patterns of behavior, interests, or activities. ASD impacts at least one out of every 59 children in the USA, although this is likely an underestimation. More...
11 Mar 2021
Image: An enzyme-linked immunosorbent assay (ELISA) measured serum 14–3-3η levels and evaluated in juvenile idiopathic arthritis (Photo courtesy of Quest Diagnostics).

Biomarker Protein Investigated in Juvenile Idiopathic Arthritis

Juvenile idiopathic arthritis (JIA) is the most common pediatric rheumatologic disease that may persist into adulthood and impact quality of life. The diagnosis is mainly based on clinical assessment rather than relying on laboratory testing. More...
09 Mar 2021
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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