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BioResearch

Image: Metastatic melanoma tumors. The micrograph on the left shows low or absent expression of RASA2, which is linked to reduced survival of about 35% of patients. The sample on the right exhibits high RASA2 expression and increased survival (Photo courtesy of the Weizmann Institute of Science).

Loss of Tumor Suppressor Gene Spurs Growth of Some Malignant Melanomas

Cancer researchers have identified a tumor suppressor gene that when damaged or lost acts to spur growth and spread of a subset of human malignant melanomas.  More...
17 Nov 2015
Image: Using DNA and RNA markers, ER stress was uncovered as the biological process responsible for the increased risk of heart disease events (Photo courtesy of Mark Dubowski, Duke University).

Combination of Genetic and Metabolic Analysis Links Endoplasmic Reticulum Stress to Cardiovascular Disease Risk

A novel investigative approach utilizing a combination of genetics, transcriptomics, epigenetics, and metabolomics has enabled researchers to link endoplasmic reticulum stress to heritable cardiovascular disease risk.  More...
17 Nov 2015
Image: Fat tissue cells are enlarged and more loosely packed in mice lacking perforin-rich dendritic cells (left) compared with the fat tissue of regular mice (right). Inset: crown-like structures within the fat tissue (left, dark brown) are associated with increased inflammation (Photo courtesy of the Weizmann Institute of Science).

A Subset of Immune T-Cells Protects Against Metabolic Syndrome in Mouse Model

A subset of immune T-cells lacking the lytic protein perforin was found to be responsible for inducing the onset of metabolic syndrome in mice fed a normal diet.  More...
16 Nov 2015
Image: Three-dimensional rendition of human blood platelets (Photo courtesy of Wikimedia Commons).

Analysis of RNA Carried by Tumor-educated Platelets Yields Valuable Diagnostic Clues

Analysis of tumor RNA carried in the afflicted individual's blood platelets may be more useful than other "liquid biopsy" technologies for diagnosing cancer and determining its primary location and potential therapeutic approaches.   More...
15 Nov 2015
Image: Diagram of the epidermal growth factor receptor (EGFR) (rainbow colored, N-terminus = blue, C-terminus = red) complexed to its ligand epidermal growth factor (magenta) (Photo courtesy of Wikimedia Commons).

Epidermal Growth Factor Receptor Stimulates Early Cancer Metastasis

The stimulation of blood vessel formation by epidermal growth factor receptor early in tumor development was found to facilitate metastasis of the original tumor even before it was diagnosed.  More...
15 Nov 2015

Purchase of Biopharmaceutical Company Will Boost Development of Nitroxyl-Based Cardiovascular Disease Drugs

A major international biopharmaceutical company has announced the acquisition of a private biotech company that specializes in the development of drugs for treatment of cardiovascular disease.   More...
15 Nov 2015
Image: Topographical images of colonies of (A) curli non-producing and (B) curli- producing strains of E. coli grown on agar for 48 hours at 28 degrees Celsius (Photo courtesy of the [US] Department of Agriculture).

Bacterial Curli Fibers Reverse Symptoms of Inflammatory Bowel Disease in Mouse Model

A novel treatment for inflammatory bowel disease based on oral administration of a single dose of purified curli fibers was successfully tested in a mouse model of acute colitis.  More...
11 Nov 2015
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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