We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App

Novel Blood Test Could Reduce Need for PET Imaging of Patients with Alzheimer’s

By LabMedica International staff writers
Posted on 05 Apr 2024
Print article
Image: An amyloid blood test can help identify patients who may forgo imaging evaluation for Alzheimer\'s disease (Photo courtesy of 123RF)
Image: An amyloid blood test can help identify patients who may forgo imaging evaluation for Alzheimer\'s disease (Photo courtesy of 123RF)

Alzheimer's disease (AD), a condition marked by cognitive decline and the presence of beta-amyloid (Aβ) plaques and neurofibrillary tangles in the brain, poses diagnostic challenges. Amyloid positron emission tomography (PET) imaging is a well-established diagnostic aid for AD but comes with high costs, invasiveness, and the need for specialist equipment, unlike blood tests. Now, new study findings have revealed that a novel amyloid blood test could reduce reliance on PET imaging for some patients experiencing mild cognitive issues to enable therapeutic focus on non-AD causes, thus expanding access to quality evaluation and reducing healthcare costs.

In what is considered one of the largest published studies, researchers evaluated the efficacy of amyloid blood testing in diagnosing AD. The study utilized 6,192 anonymized lab results from patients who were administered Quest Diagnostics’ (Secaucus, NJ, USA) AD-Detect Beta-amyloid ratio test AΒ42/40. This test measures the ratio of amyloid beta 42 and 40 proteins (Aβ42/40) found in the brain and also circulating in the bloodstream. The clinical accuracy of the Quest test was verified against 250 samples from individuals who also had amyloid PET scans and demographic data. Additionally, the study examined the blood test's performance across various interpretative ranges based on different cutoffs, or amyloid levels in the blood.

Findings from the study suggest that the Quest test, which analyzes amyloid protein levels using highly sensitive mass spectrometry, could effectively indicate when AD is unlikely to be the cause of a patient's mild cognitive impairment. The analysis showed that up to 99% of patients who tested negative for amyloid proteins in the brain via PET imaging would likely also test negative using the Quest blood test. This predictive capability could lead to a 40% reduction in the need for PET brain scans, offering significant potential healthcare cost savings for these patients.

"These findings show Aβ42/40 testing is very helpful in identifying amyloid pathology in populations with a high prevalence of AD, particularly older individuals," said Michael Racke, MD, Medical Director of Neurology at Quest Diagnostics. "We believe the comparatively low specificity reflects the limits of PET scans to identify the earliest stages of AD pathology and that many of these patients will progress to be PET-positive as the disease worsens."

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Magnetic Bead Separation Modules
Complement 3 (C3) Test
GPP-100 C3 Kit
Gold Member
Fully Automated Cell Density/Viability Analyzer
BioProfile FAST CDV

Print article


Clinical Chemistry

view channel
Image: The 3D printed miniature ionizer is a key component of a mass spectrometer (Photo courtesy of MIT)

3D Printed Point-Of-Care Mass Spectrometer Outperforms State-Of-The-Art Models

Mass spectrometry is a precise technique for identifying the chemical components of a sample and has significant potential for monitoring chronic illness health states, such as measuring hormone levels... Read more


view channel
Image: The CAPILLARYS 3 DBS devices have received U.S. FDA 510(k) clearance (Photo courtesy of Sebia)

Next Generation Instrument Screens for Hemoglobin Disorders in Newborns

Hemoglobinopathies, the most widespread inherited conditions globally, affect about 7% of the population as carriers, with 2.7% of newborns being born with these conditions. The spectrum of clinical manifestations... Read more


view channel
Image: The novel test uses an existing diagnostic procedure as its basis to target the Epstein Barr Virus (Photo courtesy of 123RF)

Blood Test Measures Immune Response to Epstein-Barr Virus in MS Patients

Multiple sclerosis (MS) is a chronic neurological condition for which there is currently no cure. It affects around three million people globally and ranks as the second most common cause of disability... Read more


view channel
Image: The T-SPOT.TB test is now paired with the Auto-Pure 2400 liquid handling platform for accurate TB testing (Photo courtesy of Shutterstock)

Integrated Solution Ushers New Era of Automated Tuberculosis Testing

Tuberculosis (TB) is responsible for 1.3 million deaths every year, positioning it as one of the top killers globally due to a single infectious agent. In 2022, around 10.6 million people were diagnosed... Read more


view channel
Image: Insulin proteins clumping together (Photo courtesy of Jacob Kæstel-Hansen)

AI Tool Detects Tiny Protein Clumps in Microscopy Images in Real-Time

Over 55 million individuals worldwide suffer from dementia-related diseases like Alzheimer's and Parkinson's. These conditions are caused by the clumping together of the smallest building blocks in the... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.