We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App

Game-Changing Tumor Marker Test Detects Gastric Cancer with Nearly 90% Accuracy

By LabMedica International staff writers
Posted on 20 Nov 2023
Print article
Image: The stromal cell-derived factor 4 (SDF-4) protein has been found to be a reliable cancer marker (Photo courtesy of Nagoya University)
Image: The stromal cell-derived factor 4 (SDF-4) protein has been found to be a reliable cancer marker (Photo courtesy of Nagoya University)

Gastrointestinal cancers like esophageal, gastric, colorectal, liver, and pancreatic cancer often reach an advanced stage before being detected, making effective treatment challenging. Identifying a biological marker that signals the presence of a tumor is crucial for early detection, diagnosis, and monitoring of cancer and its treatment. Such markers are particularly vital for cancers like gastric cancer, where early-stage treatment significantly improves outcomes and survival rates. Researchers have now identified the stromal cell-derived factor 4 (SDF-4) protein as a promising marker for cancer. This discovery is significant because simple blood tests can detect this protein, indicating its potential for early gastric cancer detection.

Current blood tests for cancers such as gastric, colorectal, and breast cancer have relied on tumor markers like CEA and CA19-9. However, these markers don't always detect every cancer accurately, and there's a need to improve their precision. Other proposed markers face hurdles such as complex and expensive measurement processes or require invasive procedures, limiting their practicality. A research team led by Nagoya University (Nagoya, Japan) set out to develop new tumor markers for early cancer detection. They focused on proteins secreted by cancer cells and identified SDF-4 as a promising marker. When they measured SDF-4 levels in blood samples from cancer patients and healthy individuals, they consistently found higher levels in those with various cancers, including gastric, esophageal, colorectal, pancreatic, breast, and liver cancers.

Sensitivity and specificity are critical in cancer diagnosis. Sensitivity measures how well a test can identify the disease in affected individuals, while specificity assesses its accuracy in healthy individuals. The team's research on the SDF-4 protein revealed a sensitivity of 89% and a specificity of 99%, surpassing the sensitivity of traditional tumor markers like CEA (13%) and CA19-9 (17%) in detecting cancer patients. Notably, high levels of the protein were observed in patients with early-stage (stage I) gastric cancer. This suggests that SDF-4 could be a significant marker for detecting cancer at an early stage, potentially before symptoms become evident.

“There are two ways in which SDF4 outperforms conventional tumor markers as a diagnostic marker. The first is that it can diagnose patients with early-stage cancer and the second is that it is useful as a diagnostic marker for various types of cancer,” said Dr. Takahiro Shinozuka, the first author of the study whose findings were published in Scientific Reports. “We are working with a company to develop measurement devices that can be used for cancer screening. If these efforts are successful, we hope to introduce SDF4 into actual cancer screening, helping in the early detection of cancer.”

Related Links:
Nagoya University

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
One Step HbA1c Measuring System
POCT Fluorescent Immunoassay Analyzer
Gold Member
Systemic Autoimmune Testing Assay
BioPlex 2200 ANA Screen with MDSS

Print article


Clinical Chemistry

view channel
Image: The new versatile assay has the ability to measure both total and bioavailable cortisol from serum (Photo courtesy of Aarhus University)

Highly Reliable Cell-Based Assay Enables Accurate Diagnosis of Endocrine Diseases

The conventional methods for measuring free cortisol, the body's stress hormone, from blood or saliva are quite demanding and require sample processing. The most common method, therefore, involves collecting... Read more


view channel
Image: The Gazelle Hb Variant Test (Photo courtesy of Hemex Health)

First Affordable and Rapid Test for Beta Thalassemia Demonstrates 99% Diagnostic Accuracy

Hemoglobin disorders rank as some of the most prevalent monogenic diseases globally. Among various hemoglobin disorders, beta thalassemia, a hereditary blood disorder, affects about 1.5% of the world's... Read more


view channel
Image: The photoacoustic spectral response sensing instrument is based on low-cost laser diodes (Photo courtesy of Khan et al., doi 10.1117/1.JBO.29.1.017002)

Compact Photoacoustic Sensing Instrument Enhances Biomedical Tissue Diagnosis

The pursuit of precise and efficient diagnostic methods is a top priority in the constantly evolving field of biomedical sciences. A promising development in this area is the photoacoustic (PA) technique.... Read more


view channel
Image: The companies will develop genetic testing systems based on capillary electrophoresis sequencers (Photo courtesy of 123RF)

Sysmex and Hitachi Collaborate on Development of New Genetic Testing Systems

Sysmex Corporation (Kobe, Japan) and Hitachi High-Tech Corporation (Tokyo, Japan) have entered into a collaboration for the development of genetic testing systems using capillary electrophoresis sequencers... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.