We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us

Download Mobile App




Urine Test Diagnoses Early-Stage Prostate Cancer

By LabMedica International staff writers
Posted on 01 May 2025

Prostate cancer is one of the leading causes of death among men worldwide. More...

A major challenge in diagnosing the disease is the absence of reliable biomarkers that can detect early-stage tumors. Now, a study published in Cancer Research reveals that prostate cancer can be diagnosed at an early stage using a simple urine sample.

Researchers from Karolinska Institutet (Stockholm, Sweden), utilizing artificial intelligence (AI) and comprehensive analyses of gene activity in prostate tumors, have discovered new biomarkers with high diagnostic accuracy. By analyzing the mRNA activity of all human genes in thousands of individual cells within prostate tumors, and considering the location and degree of cancer in each cell, the researchers were able to develop digital models of prostate cancer. These models were then analyzed with AI to identify proteins that could serve as biomarkers. The identified biomarkers were subsequently tested in the blood, prostate tissue, and urine of nearly 2,000 patients.

The team discovered a set of biomarkers in urine that could accurately indicate both the presence and severity of prostate cancer. According to their findings, these biomarkers outperform PSA, the blood biomarker currently used in clinical practice. The next phase of research involves large-scale clinical trials to further validate these results. More precise biomarkers than PSA could lead to earlier detection and better prognoses for men with prostate cancer. Additionally, they could help reduce the number of unnecessary prostate biopsies in healthy men.

“There are many advantages to measuring biomarkers in urine,” explains principal investigator Mikael Benson, senior researcher at the Department of Clinical Science, Intervention and Technology, Karolinska Institutet. “It’s non-invasive and painless and can potentially be done at home. The sample can then be analyzed using routine methods in clinical labs.”


New
Gold Member
Blood Gas Analyzer
Stat Profile pHOx
POC Helicobacter Pylori Test Kit
Hepy Urease Test
New
Alcohol Testing Device
Dräger Alcotest 7000
New
HBV DNA Test
GENERIC HBV VIRAL LOAD VER 2.0
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Hematology

view channel
Image: Platelets sequester cfDNA during circulation (Murphy L. et al., Science, 2025; DOI: 10.1126/science.adp3971)

Platelets Could Improve Early and Minimally Invasive Detection of Cancer

Platelets are widely recognized for their role in blood clotting and scab formation, but they also play a crucial role in immune defense by detecting pathogens and recruiting immune cells.... Read more

Immunology

view channel
Image: The test could streamline clinical decision-making by identifying ideal candidates for immunotherapy upfront (Xiao, Y. et al. Cancer Biology & Medicine July 2025, 20250038)

Blood Test Predicts Immunotherapy Efficacy in Triple-Negative Breast Cancer

Triple-negative breast cancer (TNBC) is an aggressive subtype lacking targeted therapies, making immunotherapy a promising yet unpredictable option. Current biomarkers such as PD-L1 expression or tumor... Read more

Microbiology

view channel
Image: New diagnostics could predict a woman’s risk of a common sexually transmitted infection (Photo courtesy of 123RF)

New Markers Could Predict Risk of Severe Chlamydia Infection

Chlamydia trachomatis is a common sexually transmitted infection that can cause pelvic inflammatory disease, infertility, and other reproductive complications when it spreads to the upper genital tract.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.