We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App

Strip-Type Urine Sensor Diagnoses Cancer Quickly and With High Sensitivity

By LabMedica International staff writers
Posted on 15 Feb 2023
Print article
Image: Researchers have developed a new on-site rapid cancer early diagnosis sensor technology (Photo courtesy of KIMS)
Image: Researchers have developed a new on-site rapid cancer early diagnosis sensor technology (Photo courtesy of KIMS)

Various blood tests, radiological methods and histological analysis are currently used to diagnose cancer. Annual health checkups can also reveal the presence of cancer, although the disease is mostly detected after it has advanced considerably, resulting in delayed treatment or death. Now, a research team has developed a strip-type urine sensor that can amplify the light signal of metabolites in urine to help diagnose cancer.

The technology developed by researchers at Korea Institute of Materials Science (KIMS, Gyeongsangnam-do, South Korea) could find application in screening for prostate cancer and pancreatic cancer by irradiating light using a small volume (10uL) of urine taken at the time of the test without the need for any additional analysis process. The test device is in the form of a strip that allows cancer to be diagnosed quickly and with high sensitivity. As a biological sample, urine can be easily obtained, making the test more accessible. The urine-based diagnosis method could be used for on-site rapid cancer screening or as recurrence monitoring technology following treatment of cancer patients. Additionally, the strip-type sensor has a low manufacturing cost that will allow it to be used for mass consumption.

The research team developed the strip-type sensor by focusing on the metabolomic components present in the urine of cancer patients and normal people. In cancer patients, proliferating cancer cells secrete various metabolites into urine owing to abnormal metabolism. Classifying these metabolites in urine using existing technology requires large and expensive equipment, thus limiting its on-site application. In order to overcome this challenge, the researchers developed a surface-enhanced Raman scattering sensor that amplifies the optical signal of metabolites in urine by more than one billion times. When the urine sample is dropped into the sensor and light is irradiated, the cancer metabolite signals tend to become amplified on the surface of the sensor, enabling the diagnosis of cancer. Upon applying an artificial intelligence (AI)-based analysis method to the acquired spectral signal, the researchers were able to identify up to 99% of prostate cancer and pancreatic cancer patients.

“In the case of cancers where the diagnosis method is not well known, such as pancreatic cancer, it is difficult to detect and the survival rate after initial diagnosis is low,” said Dr. Ho Sang Jung of the Surface & Nano Materials Division of KIMS, a senior researcher in charge of the research. “Since early diagnosis is the most important for incurable diseases such as cancer, we expect this technology to provide a new diagnostic method.”

Related Links:

Platinum Supplier
Xylazine Immunoassay Test
Xylazine ELISA
Gold Supplier
Automatic Nucleic Acid Workstation
Bordetella Test
Panther Fusion Bordetella Assay
Scalable Loopamp System

Print article


Molecular Diagnostics

view channel
Image: The ClarityDX Prostate test can reduce unnecessary prostate biopsies by up to 35% (Photo courtesy of Nanostics)

Innovative Blood Test to Revolutionize Prostate Cancer Detection and Reduce Invasive Biopsies

One in six men will receive a prostate cancer diagnosis during their lives. Thankfully, if caught early, prostate cancer is highly treatable. However, the existing screening process has its limitations.... Read more


view channel
Image: The latest FDA clearance has finally brought HemoScreen to its full potential as a true POC hematology analyzer (Photo courtesy of PixCell)

True POC Hematology Analyzer with Direct Capillary Sampling Enhances Ease-of-Use and Testing Throughput

An innovative 5-part differential Complete Blood Count (CBC) analyzer with direct capillary sampling capability significantly simplifies blood sampling and minimizes the pre-analytical process.... Read more


view channel
Image: A new test could detect the body’s adaptive immune response to viruses (Photo courtesy of 123RF)

Predictive T-Cell Test Detects Immune Response to Viruses Even Before Antibodies Form

The adaptive immune system is an incredible defense mechanism that allows the human body to identify and mount targeted responses against specific pathogens. T-Cells, a special kind of white blood cell,... Read more


view channel
Image: On-chip pretreatment and rapid AST based directly on positive blood cultures (Photo courtesy of Liu Yang)

Integrated Solution for Rapid AST Directly From Positive Blood Cultures to Combat Bloodstream Infection

The presence of living bacteria in the bloodstream, known as bacteremia, can lead to serious conditions like bloodstream infections (BSIs) and sepsis, which can often be fatal. Quickly prescribing the... Read more


view channel
Image: A new microscopy method detects treatment-resistant cancer cells early (Photo courtesy of 123RF)

New Rapid-Live Screening Microscopy Technique Enables Early Detection of Treatment-Resistant Cancer Cells

Chemotherapy serves as an effective tool in the fight against cancer, yet some cancer cells can evade treatment by going into a dormant state known as senescence. These so-called therapy-induced senescent... Read more


view channel
Image: A new electrochemical device can quickly and inexpensively identify people at greatest risk for osteoporosis (Photo courtesy of ACS Central Science, 2023)

Electrochemical Device Identifies People at Higher Risk for Osteoporosis Using Single Blood Drop

With the global increase in life expectancy, the incidence of age-related conditions like osteoporosis is increasing. Osteoporosis, affecting around 200 million individuals worldwide, has a higher incidence... Read more


view channel
Image: AACC Middle East is a two-day conference that brings the latest in laboratory medicine to the Middle East region (Photo courtesy of ADLM)

AACC Middle East 2023 to Explore Latest Trends in Clinical Pathology and Laboratory Medicine

The AACC Middle East Conference and Exposition will be held by the Association for Diagnostics & Laboratory Medicine (ADLM - formerly AACC, Washington, DC, USA) in partnership with Life Dx (Abu Dhabi,... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.