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Pathology

Image: A photomicrograph of pigmented malignant melanoma in a Papanicolaou stained cytology specimen, (Photo courtesy of Nephron).

Melanoma Biomarkers Predict Checkpoint Blocker Response

The outlook for patients with advanced melanoma has dramatically improved in recent years because of drugs known as immune checkpoint inhibitors, which mobilize the immune system to attack cancer. These drugs block checkpoint molecules that act as brakes on the immune system and unleash immune defenders such as T cells to recognize and attack cancer. More...
02 Aug 2018
Image: The Sensiscript reverse transcription kit is ideally suited for highly sensitive applications using very small amounts of RNA (Photo courtesy of Qiagen).

New Target Protein for Colon Cancer Identified

Colorectal cancer (CRC) is the third most commonly diagnosed cancer and the third leading cause of cancer-related death in men and women in the USA. Pathogenic mediators that regulate CRC tumorigenesis are desirable biomarkers to predict prognosis, recurrence of the disease, and response to therapy to improve the management of patients with CRC. More...
02 Aug 2018
DIASOURCE (A Biovendor Company)
Image: A malignant melanoma of the skin (Photo courtesy of National Cancer Institute).

Biomarker Detects Active Melanoma and Predicts Survival

Melanoma is the most dangerous form of skin cancer, these cancerous growths develop when unrepaired DNA damage to skin cells, which is most often caused by ultraviolet radiation from sunshine or tanning beds, triggers mutations (genetic defects) that lead the skin cells to multiply rapidly and form malignant tumors. More...
25 Jul 2018
Image: An immunohistochemistry staining for expression of the estrogen receptor positivity (ER+) showing strong nuclear reactivity (Photo courtesy of the Indian National Institute of Pathology).

Cancer Genetics Highlight Mutations Linked to Drug Response

A range of somatic driver alterations has been described in estrogen receptor–positive, HER2-negative (ER+/HER2−) early breast cancer (BC); however, the clinical relevance is unknown. More...
19 Jul 2018
Image: A histopathology of mixed germ cell tumor of the testes demonstrating the high-grade cytology, typical for embryonal carcinoma (Photo courtesy of Nephron).

Integrated Analyses Offer Molecular Insights to Tumor Subtypes

The most common malignancy of young adult males of European descent are testicular germ cell tumors (TGCTs) of the type derived from germ cell neoplasia in situ (GCNIS). There are two major histologic types: pure classic seminoma and nonseminomatous germ cell tumors (NSGCTs). More...
19 Jul 2018
Image: Elevated levels of prostate specific antigen (PSA) in the blood can be an indicator of prostate cancer and lead to further diagnostic investigations (Photo courtesy of KeraNews).

Obesity Affects Prostate Cancer Test Results

Elevated levels of prostate specific antigen (PSA) in the blood can be an indicator of prostate cancer and lead to further diagnostic investigations. More...
17 Jul 2018
Image: A 3T brain magnetic resonance imaging showing white matter damage (Photo courtesy of Professor Rebecca Gottesman).

Inflammation Marker Tied to Dementia Increases with Age

Scientists have added to evidence that rising and chronic inflammation as measured by a biomarker in the blood in middle and late age are linked to visible structural changes in the brains of people with poor cognition and dementia. More...
17 Jul 2018
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The Pathology channel details advances in the field of Surgical Pathology and all its subspecialties, including Cytopathology and its subspecialties.
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