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Immunology

Image: This illustration reveals ultrastructural morphology exhibited by coronaviruses. Note the spikes that adorn the outer surface of the virus, which impart the look of a corona surrounding the virion, when viewed electron microscopically (Photo courtesy of Centers for Disease Control and Prevention).

Certain Cytokines Not Associated with Severity of COVID-19 Symptoms

The pandemic outbreak of coronavirus disease 2019 (COVID-19) is sharply spreading all over the world. The severity of a viral disease usually is positive association with immune-mediated inflammatory responses. The aggressive and persistent inflammatory response leads to high risk of multiorgan failure and death. More...
24 Jun 2020
Image: Presepsin concentrations (ng/mL) in two severity groups. Black line: sepsis patients; black dotted line: septic shock patients (Photo courtesy of University Hospital for Infectious Diseases in Zagreb).

Presepsin Values Evaluated as Sepsis Severity Markers

Sepsis is a life-threatening condition, with poor and highly variable clinical manifestations, difficult to identify and diagnose. Sepsis has remained a real diagnostic challenge to clinicians, causing millions of death worldwide each year. Early recognition of sepsis is crucial for better disease outcome. More...
23 Jun 2020
DIASOURCE (A Biovendor Company)
Image: The single gene, Cystic Fibrosis Transmembrane Regulator (CFTR) gene is located on the long arm of chromosome 7, and its mutations cause CF (Photo courtesy of Daryl Isaac).

Biomarkers Evaluated for Lung Disease Severity in Cystic Fibrosis

Cystic fibrosis (CF) is one of the most common life-shortening monogenic disorders amongst European-derived populations currently affecting more than 85,000 patients worldwide. The diagnosis of CF is based on consensus clinical and laboratory criteria. More...
22 Jun 2020
Image: The Loa Antibody Rapid Test detects human IgG against a 148-aminoacid sequence of Ll-SXP-1 (Photo courtesy of Drugs & Diagnostics for Tropical Diseases).

Two Serodiagnostic Tests Compared for Loiasis in Non-Endemic Area

Loiasis, the disease caused by the infection with the filarial nematode Loa loa, is transmitted through the bite of tabanid flies of the genus Chrysops. It is endemic in Central and West Africa where, according to the most recent estimates, about 10 million people are infected. More...
18 Jun 2020
Image: Schematic representation of the remote electrochemiluminescence (ECL) mechanism (Photo courtesy of University of Bologna).

Increasingly Efficient Serological Tests Developed with Electrochemiluminescence

Diagnostic markers, or biomarkers, are biomolecules (e.g., enzymes, proteins, peptides, and hormones) that can be measured accurately and reproducibly and can precisely predict relevant clinical outcomes or diseases in various populations. More...
17 Jun 2020
Image: Myeloid-derived suppressor cells in the tumor microenvironment have been observed in a variety of solid tumors (Photo courtesy of BMS Immuno-Oncology).

Tumor Mutation and Immune Microenvironment Revealed in Colorectal Cancer

Most colorectal cancers are due to old age and lifestyle factors, with only a small number of cases due to underlying genetic disorders. Other risk factors include diet, obesity, smoking, and lack of physical activity. Dietary factors that increase the risk include red meat, processed meat, and alcohol. More...
10 Jun 2020
Image: Four Plasmodium vivax parasites have invaded human hepatocytes. Three of the parasites are developing while one parasite, on the lower left, is a dormant hypnozoite, which remains small until its reactivation (Photo courtesy of Nil Gural).

Serological Exposure Markers Developed for Vivax Malaria

Plasmodium vivax is the most widespread malaria parasite worldwide, with up to two billion people at risk of infection. As well as causing illness and death in its 'active' stage of infection, the parasite can hide as hypnozoites, a dormant stage, in the liver, and is a significant cause of 'relapsing' malaria. More...
10 Jun 2020
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The Immunology channel of LabMedica deals with diagnostic techniques and immuonassays such as ELISA, pregnancy tests, immunoblotting, immunohistochemical staining, serology, and associated hardware.

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