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Clinical Chemistry

Image: Challenged urine bicarbonate excretion offers safe assessment of reduced CFTR function (Photo courtesy of Pexels)

Urine Bicarbonate Test Offers Safe Quantification of CFTR Function in Cystic Fibrosis Patients

A study of patients with cystic fibrosis has found that challenged urine bicarbonate excretion may offer a new, simple, and safe quantification of cystic fibrosis transmembrane conductance regulator (CFTR) function and the extent of its pharmacologic improvement. More...
02 Nov 2022
Image: Development of an artificial biosynthetic pathway for chemically tagged UDP-GalNAc/GlcNAc analogues (Photo courtesy of Benjamin Schumann, PhD)

Cell-Specific Bioorthogonal Tagging of Glycoproteins Developed

Altered glycoprotein expression is an undisputed corollary of cancer development. Understanding these alterations is paramount but hampered by limitations underlying cellular model systems. For instance, the intricate interactions between tumor and host cannot be adequately recapitulated in monoculture of tumor-derived cell lines. More...
31 Oct 2022
Image: The team combined powerful AI and a molecule-making machine to find the best conditions for automated complex chemistry (Photo courtesy of University of Illinois at Urbana-Champaign)

AI Combined with Molecule-Making Machine Could Make Complex Chemistry Automated and Accessible

A research team has combined AI, “building-block” chemistry and a molecule-making machine to find the best general reaction conditions for synthesizing chemicals important to biomedical and materials research – a finding that could speed innovation and drug discovery as well as make complex chemistry automated and accessible. More...
31 Oct 2022
Image: The Thermo Fisher Scientific Orbitrap Velos mass spectrometer features dual-pressure linear ion trap technology that delivers increased sensitivity and dynamic range with ultimate robustness (Photo courtesy of University of Michigan)

Lipidomic Determinants Profiled for Human Diabetic Neuropathy

Peripheral neuropathy is a common complication of type 2 diabetes, ranging in prevalence from 10% to over 50% in various cohorts. Peripheral neuropathy symptoms manifest as a loss of sensation and pain in a length-dependent manner. Peripheral neuropathy in type 2 diabetes remains recalcitrant to effective treatment; glucose control only marginally prevents neuropathy onset and development. More...
05 Oct 2022
Image: Neutrophil gelatinase-associated lipocalin (NGAL) Duo Set ELISA (Photo courtesy of R&D Systems)

Synovial Fluid NGAL Accurately Diagnoses Prosthetic Joint Infection

Prosthetic joint infection (PJI) is a serious complication that is difficult to diagnose after joint arthroplasty and seriously affects the physical and mental health of patients. Current studies suggest that PJI is a relatively limited infectious disease, and the synovial fluid (SF) biomarkers more directly reflect the nature and extent of inflammation. More...
04 Oct 2022
Image: The Article Transfer Service is designed to help manuscripts find the right journal faster (Photo courtesy of Elsevier)

Article Submission Process Streamlined for Clinica Chimica Acta and Related Journals

An initiative by Elsevier BV (Amsterdam, Netherlands), one of the world's largest scientific publishers with around 300 journals including Clinica Chimica Acta, aims to help authors find the best journal match for their article, quickly and easily. More...
26 Sep 2022
Image: High-sensitivity cardiac troponin I: relying on the sex-specific 99th percentile upper reference limit of cardiac troponin may incorrectly suggest myocardial infarction (MI) in older adults with suspected heart attacks (Photo courtesy of Blood Tests in London)

Age Alters Diagnostic Performance of Cardiac Troponin

The guideline-recommended thresholds for increased high-sensitivity cardiac troponin I (hs-cTnI), indicating myocardial injury and potential infarction, performed at a similar sensitivity around 80% in people across age groups. More...
20 Sep 2022
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.

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