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Clinical Chemistry

Image: The Phadia 200 instrument is capable of diagnostic testing menu of more than 700 different ImmunoCAP and EliA tests to aid in the diagnosis of allergy and autoimmune diseases (Photo courtesy of Thermo Fisher Scientific)

Calprotectin Levels Vary When Measured in Different Matrices for COVID-19

Several risk scores, diagnostic imaging and biomarkers have been evaluated and compared to help predict severe complications and outcome in COVID-19 patients. Nevertheless, early prediction of COVID-19 severity remains difficult, emphasizing the need for additional biomarkers in daily practice. More...
28 Dec 2021
Image: Schematic graphics showing how variation in common laboratory test results caused by ambient temperature (Photo courtesy of Cell Press)

Seasonal Temperature Impacts Patients’ Laboratory Results

Every year, 13 billion laboratory tests are performed in the USA, nearly 800 million in the UK, and many more worldwide. Test results provide critical data on clinically important changes in patient physiology. More...
23 Dec 2021
DIASOURCE (A Biovendor Company)
Image: D-Serine is useful for the measurement of glomerular filtration rate (GFR). The clearance of D-serine has an advantage of lower bias against GFR compared to that with the creatinine clearance. Combinational clearance measurement of D-serine and creatinine can serve as a measure of GFR with precision and low bias (Photo courtesy of Tomonori Kimura, MD, PhD)

D-Serine Clearance Evaluates Precise Measurement of Kidney Function

Evaluation of kidney function is essential in daily clinical practice. The measured glomerular filtration rate (mGFR) using exogenous inulin has been considered as the gold standard of kidney function, though this procedure is labor intensive, time consuming, and expensive. More...
21 Dec 2021
Image: The ARCHITECT i2000SR automated immunoassay instrument system (Photo courtesy of Abbott Laboratories)

Long-Term Storage Stability of Corticotropin Investigated

Corticotropin (adrenocorticotropic hormone, ACTH) is a 39-residue polypeptide tropic hormone secreted by the anterior pituitary gland following hypothalamic corticotropin-releasing hormone release. Corticotropin is notorious for its instability. More...
20 Dec 2021
Image: The CLARIOstar Plus is a multi-mode microplate reader with advanced LVF Monochromators, highly sensitive filters, and an ultra-fast UV/vis spectrometer (Photo courtesy of BMG Labtech)

Circulating ACE2 Activity Predicts Mortality and Severity in COVID-19 Patients

Coronavirus disease 2019 (COVID-19) has been associated with significant morbidity and mortality worldwide in the last two years. This disease is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. More...
16 Dec 2021
Image: The Genetic Screen Processor (GSP) is a high throughput batch analyzer intended for quantitative or qualitative measurement of neonatal screening samples on 96-well microplates (Photo courtesy of PerkinElmer)

Cord Blood and Filter Paper Screening Compared for Congenital Hypothyroidism

The most prevalent predisposing factor to intellectual disability is congenital hypothyroidism (CH), which is referred to the deficiency in thyroid hormone since birth. It could be either transient or persistent deficiency. Persistent deficiency of thyroid hormone requires life-long thyroid hormone replacement. This state is known as permanent congenital hypothyroidism. More...
15 Dec 2021
Image: The Vantera Clinical Analyzer can identify and quantify concentrations of choline using NMR spectroscopy (Photo courtesy of American Association for Clinical Chemistry)

Serum and Plasma Choline Quantified by Clinical NMR- Analyzer

Gut microbiome-related metabolites, like trimethylamine-N-oxide (TMAO), betaine and choline are increasingly recognized as contributors to, as well as markers of, cardiometabolic and other chronic diseases. Gut microbiome mediated metabolism of phosphatidylcholine leads to the production of choline, which is then metabolized to either trimethylamine (TMA) or betaine. More...
14 Dec 2021
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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