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Clinical Chemistry

Image: ROC curve AUC and levels of Proenkephalin A 119–159 (PENK) 48 hours after liver transplantation in the need-renal replacement therapy groups (Photo courtesy of University of Sao Paulo)

Biomarker Proenkephalin Investigated in Diagnosis of Acute Kidney Injury

Liver transplantation (LT) is the only treatment available for patients with end-stage liver disease, such as liver cancer or acute and subacute liver failure. Among the various types of postoperative organ damage, acute kidney injury (AKI) is particularly prevalent, developing in 5% to 20% of patients undergoing major non-cardiac surgery. More...
12 May 2022
Image: a) Schematic of Tear Collection using Schirmer strip before being analyzed by LC-MS/MS and validated by ELISA. b) Functional classification of 301 mapped proteins in tear samples using PANTHER classification system (Photograph courtesy of Namida Lab)

Tear-Based Method Detects Breast Cancer

With advances in screening techniques, and adjustment of recommended screening guidelines, mortality rates due to breast cancer continue to decline. Despite the estimated waning in mortality rates, breast cancer still remains the highest cancer diagnosis of women globally. More...
11 May 2022
Image: TripleTOF 6600+ System optimized for large-scale quantitative mass spectrometry and offers sensitive and robust quantitation using dedicated low flow source technology (Photo courtesy of Sciex)

Proteins Linked to COVID-19-Associated Inflammatory Syndromes

COVID-19 associated acute respiratory distress syndrome (COVID-19 ARDS) is one of the major manifestations of the severe cases, characterized by hypoxemic respiratory failure with bilateral lung infiltrate, as well as multi-organ dysfunction and extensive microthrombus formation. More...
10 May 2022
Image: The Phadia 250 Immunoassay Analyzer, in addition to allergy testing, allows measurement of autoantibodies of more than 20 autoimmune related diseases using the EliA product line (Photo courtesy of Thermo Fisher Scientific)

Biochemical Abnormalities Among Celiac Disease Patients Referred for Antibody Testing

Celiac disease (CD) is a chronic disease occurring in all age groups and affecting approximately 1% of the population, although many cases of CD remain undiagnosed. This condition is caused by an abnormal immune response in genetically susceptible individuals triggered by the ingestion of gluten proteins from wheat, rye and barley. More...
09 May 2022
Image: Smart diaper is designed for bedside urine testing (Photo courtesy of Unsplash)

Smart Diaper Could Provide Quick and Painless Bedside Urinalysis

Researchers have designed a flexible sensor that fits in a diaper, measures multiple components in urine and can share those results over Bluetooth to provide real-time bedside analyses for incontinent, elderly or infant patients. More...
06 May 2022
Image: N-terminal pro-B-type natriuretic peptides (NT-proBNP) concentration could mean drastically different absolute risks of heart failure (HF) for different demographics (Photo courtesy of TCTMD)

NT-proBNP Underestimates Heart Failure Risk for Certain Patients

The N-terminal pro-B-type natriuretic peptides (NT-proBNP) concentration could mean drastically different absolute risks of heart failure (HF) for different demographics, according to a cohort study suggesting the importance of sex and race in interpreting risk for people free of HF at baseline. More...
03 May 2022
Image: Study demonstrates significant inconsistencies with pediatric reference interval (Photo courtesy of Unsplash)

Groundbreaking Study Points to Crucial Gap in Children’s Clinical Testing

A groundbreaking study has demonstrated significant inconsistencies with pediatric reference intervals, which are essential to high quality pediatric medical testing. More...
03 May 2022
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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