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Clinical Chemistry

Image: The Nexera X2 Ultra High Performance Liquid Chromatography (UHPLC) system (Photo courtesy of Shimadzu).

Neonatal Vitamin D Status Linked to Schizophrenia Risk

Schizophrenia is a poorly understood group of brain disorders characterized by impairments in cognition, perception and affect, with a lifetime prevalence of 0.7%. People with schizophrenia may seem like they have lost touch with reality. More...
18 Dec 2018
Image: A section from the hippocampus of an Alzheimer’s disease patient stained with a tau antibody (TNT1). Note the classical triad of tau pathologies in AD, 1) neurofibrillary tangles (arrowheads), 2) neuropil threads (arrows), and 3) a neuritic plaque (asterisk) (Photo courtesy of Michigan State University).

Tau Blood Test Developed for Alzheimer's Disease

Presently, the only way to definitively diagnose Alzheimer's disease in life is through brain scans and tests of cerebrospinal fluid that must be collected via lumbar puncture. Though cumbersome and expensive, such tests provide the most accurate diagnoses for patients. More...
17 Dec 2018
DIASOURCE (A Biovendor Company)
Image: The continuous glucose monitoring (CGM) system (Photo courtesy of Medtronic).

Diabetic Retinopathy Linked to Glycemic Variability in Type 2-Diabetes

Latent autoimmune diabetes in adults (LADA) refers to adult diabetes patients who are initially non‐insulin requiring, but have type 1 diabetes mellitus‐associated autoantibodies and who often progress to insulin dependency. More...
13 Dec 2018
Image: The BC-5390CRP blood cell analyzer (Photo courtesy of Mindray).

Potential Biomarkers Found for Acute Aortic Dissection

An aortic dissection is a serious condition in which the inner layer of the aorta, the large blood vessel branching off the heart, tears. Blood surges through the tear, causing the inner and middle layers of the aorta to separate (dissect). More...
10 Dec 2018
Image: Neuropathy is the damage of peripheral nerves; pain and loss of sensation in the extremities and can be caused by diabetes (Photo courtesy of Alnoor Ladhani).

Routine Vitamin B12 Screening May Prevent Irreversible Nerve Damage

The increasing incidence of type-2 diabetes is a serious health issue worldwide. Its prevalence is associated with poor diet and unhealthy lifestyle choices, and it is characterized by high blood glucose levels that need to be controlled by medication. More...
05 Dec 2018
Image: The ARCHITECT B.R.A.H.M.S PCT assay, which is a two-step immunoassay using chemiluminescent microparticle immunoassay (CMIA) technology (Photo courtesy of Abbott Laboratories).

Commercial Fully Automated Procalcitonin Immunoassay Compared

Procalcitonin (PCT), a 13-kDa peptide precursor of calcitonin, has gained widespread acceptance as an early and specific biomarker for the presence of systemic bacterial infection. In particular, PCT monitoring has demonstrated value in guiding antibiotic use for bacterial infections. More...
04 Dec 2018
Image: The FLEXMAP 3D instrument is an advanced and versatile multiplexing platform. The platform uses both magnetic and non-magnetic microspheres and is capable of simultaneously measuring up to 500 genes or proteins from a small sample (Photo courtesy of Luminex).

Plasma Human Proteins Associated with Acute Pediatric Malaria

Severe malaria caused by Plasmodium falciparum continues to be one of the leading infectious causes of morbidity and mortality in children worldwide. The intimate interaction between the pathophysiology of the human host and the biology of the P. falciparum parasite results in a wide spectrum of disease outcomes in malaria. More...
27 Nov 2018
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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