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Clinical Chemistry

Image: The i-STAT cardiac troponin I assay; healthcare professionals can obtain quantitative measurement of cardiac troponin I (cTnI) in ten minutes without leaving the patient\'s side (Photo courtesy of Abbott Point of Care).

Novel POC Troponin Assay Rules Out Acute MI

More than seven billion diagnostic tests are run in the USA each year to help physicians make accurate, timely decisions about a person's medical treatment. Emergency department (ED) investigations of patients with suspected acute myocardial infarction (AMI) are time consuming, partly because of the turnaround time of laboratory tests. More...
05 Nov 2018
Image: The Dade Behring BN100 nephelometer (Photo courtesy of Siemens Healthineers).

Chronic Inflammation Linked to Risk for Alzheimer's Disease

While it has been widely shown that possessing the apolipoprotein E4 (ApoE4) gene is the major genetic risk factor of Alzheimer's disease (AD), not all ApoE4 carriers develop AD. It is likely that a complex interaction of genetic vulnerabilities with environmental risk factors lead to AD and identifying such factors could be beneficial for the prevention of AD. More...
30 Oct 2018
Image: This device uses laser technology to detect glucose levels under the skin, an alternative to painful pricking (Photo courtesy of University of Missouri-Columbia).

Noninvasive Blood Glucose Test Evaluated for Accuracy

For those living with diabetes, monitoring blood glucose accurately is necessary to prevent diabetes-related complications such as heart attacks, blindness and coma. Optical monitoring of blood glucose levels for non-invasive diagnosis is growing. More...
23 Oct 2018
Image: Higher levels of the inflammatory biomarker soluble tumor necrosis factor receptor-1 (sTNFR-1) are tied to kidney decline in healthy adults (Photo courtesy of Enbrel).

Kidney Function Decline Linked with Inflammatory Marker Levels

Tumor necrosis factor receptor-1 (TNFR-1), which plays a causative role in endothelial cell dysfunction and inflammation, is expressed on the cell surface in glomerular and peritubular capillary endothelium of the kidneys. More...
15 Oct 2018
Image: An albumin immunoturbidimetric assay urine or serum plasma; standard microalbumin range is 0.4-500mg/L (Photo courtesy of Sentinel Diagnostics).

Kidney Disease Biomarker May Indicate Lung Problems

Chronic lower respiratory diseases (CLRD) are the fourth leading cause-of-death and a major source of health care costs. CLRD includes chronic obstructive pulmonary disease (COPD), chronic bronchitis, emphysema, and asthma, airflow limitation as a physiologic correlate, and acute exacerbations as the major clinical manifestation. More...
09 Oct 2018
Image: The QTRAP 6500 Q-Trap mass spectrometer (MS) (Photo courtesy of Sciex).

Collection Tubes Influence Targeted Metabolomics Studies

Plasma and serum are the most widely used matrices in clinical studies. However, some variability in absolute concentrations of metabolites are likely to be observed in these collection tubes matrices. More...
08 Oct 2018
Image: An illustration of early cardiac troponin kinetics in patients after acute myocardial injury including acute myocardial infarction (Photo courtesy of ESC Scientific Document Group).

Blood Tests Differentiate Myocardial Injury from Infarction

Myocardial infarction represents the death of myocardial cells and is characterized by acute myocardial ischemia. Nonischemic myocardial injury by comparison is often associated with other conditions such as renal failure or heart conditions like myocarditis. More...
03 Oct 2018
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.
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