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Clinical Chemistry

The MiSeqDx System is the first FDA-regulated, CE-IVD-marked, NGS platform for in vitro diagnostic (IVD) testing (Photo courtesy of Illumina)

Insulin Resistance and T2D Associated With Gut Microbial Diversity

Type 2 diabetes (T2D) is a common complex metabolic disorder. Currently, more than 380 million people live with type 2 diabetes globally, and this number is expected to increase to more than 550 million by 2030. More...
13 Aug 2021
Photomicrograph shows brown-immunostained alpha-synuclein in Lewy bodies (large clumps) and Lewy neurites (thread-like structures) in the neocortical tissue of a person who died with Lewy body disease (Photo courtesy of Movalley)

CSF Conversion Assay Identifies Lewy Body Disease Cognitive Impairment

Lewy body dementia, also known as dementia with Lewy bodies, is the second most common type of progressive dementia after Alzheimer's disease. Protein deposits, called Lewy bodies, develop in nerve cells in the brain regions involved in thinking, memory and movement (motor control). More...
08 Aug 2021
The Invitrogen Human EGF ELISA Kit measures levels of epidermal growth factor (EGF) in human serum, plasma, and cell culture supernatant using 96-well plates (Photo courtesy of Thermo Fisher Scientific)

Urinary Epidermal Growth Factor Investigated for Diabetes Nephropathy

Type 1 diabetes mellitus is an auto-immune metabolic disease with chronic hyperglycemia. For many patients with type 1 diabetes (T1DM), it is challenging to maintain near-normal glucose blood levels and to reduce the risk of both acute (hypoglycemia, ketoacidosis) and chronic microvascular (retinopathy, neuropathy and nephropathy) and macrovascular complications. More...
06 Aug 2021
Image: Immunoscreening of TIA antigens by SEREX. Bacterial proteins including phage cDNA products were blotted on nitrocellulose membranes and reacted with the sera of patients with transient ischemic attack (TIA); arrows indicate positive phage clones (Photo courtesy of Chiba University)

ALDOA and FH4 Antibodies Associated with Cerebrovascular Disease

Ischemic stroke, including transient ischemic attack (TIA) and cerebral infarction (CI), is the most globally recognized cerebrovascular disorder, and is a serious health problem in the aging society. CI is an episode of neurological dysfunction caused by focal brain infarction, often resulting in fatality and disability. Patients with TIA are at a high risk of CI. More...
28 Jul 2021
Image: The Lumipulse G β-amyloid 1-40 assay kit (Photo courtesy Fujirebio)

APOE Gene Influences Alzheimer's Symptoms, Biomarkers in Down Syndrome

Individuals with Down syndrome (DS) constitute a population at ultrahigh risk of developing Alzheimer disease (AD) because of trisomy of chromosome 21, which harbors the amyloid precursor protein (APP) gene. More...
22 Jul 2021
Image: The ROCHE Cobas 6000 Chemistry Analyzer (Photo courtesy of Roche Diagnostics)

Elevated PlGF Levels Found with Acute Fatty Liver of Pregnancy

Acute fatty liver of pregnancy (AFLP) is a severe liver disorder unique to pregnancy, typically occurring after 30 weeks’ gestation. Although uncommon, with an estimated global incidence of 1 in 7,000 to 15,000 pregnancies, AFLP is a life-threatening disease for both mother and child. More...
22 Jul 2021
Image: The VITROS ECiQ Immunodiagnostic System (Photo courtesy of Ortho Clinical Diagnostics)

Novel Adipokine Biomarker Reported for Insulin Resistance and Atherosclerosis

Diabetes Mellitus is a chronic condition occurring due to inadequate production or inadequate action of insulin, ultimately leading to hyperglycemia. Prediabetes, regarded as a precursor of diabetes, is a condition with elevated plasma glucose above normal levels, but below that of clinical disease. More...
21 Jul 2021
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The Clinical Chemistry channel updates the reader on tests, techniques, and research in the field - from routine assays to specialized tests on blood, urine, enzymes, lipids, hormones and more.

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