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BioResearch

Image: A mixed surface–ribbon representation of the catalytic domain of human poly (ADP-ribose) polymerase 1 (PARP1) binding the small-molecule inhibitor olaparib (shown as a space-filling model) (Photo courtesy of Wikimedia Commons).

Anticancer Duo Kills Tumors While Preventing Relapse

A suggested new therapeutic approach for killing tumor cells simultaneously blocks both the PARP and RAD52 DNA repair pathways. More...
28 Jun 2018
Image: Alpha-synuclein in mitochondria of neuron (left) and single molecule TIRF image of individual alpha-synuclein aggregates (right) (Photo courtesy of Mathew Horrocks).

Development of PD Linked to Mitochondrial Damage

An international team of neurodegenerative disease researchers has suggested a mechanism that links mitochondrial damage caused by insoluble fibrils of alpha-synuclein to the development of Parkinson's disease. More...
27 Jun 2018
Image: Extracellular vesicle-like metal-organic framework nanoparticles are developed for the intracellular delivery of biofunctional proteins. The biomimetic nanoplatform can protect the protein cargo and overcome various biological barriers to achieve systemic delivery and autonomous release (Photo courtesy of the Zheng Laboratory, Pennsylvania State University).

Novel Use of Nanoparticles Developed for Targeted Drug Delivery

The innovative use of metal-organic framework nanoparticles has enabled the development of a delivery system for therapeutic proteins that selectively targets tumor cells. More...
26 Jun 2018
Image: Immune cells that ingested spider silk nanoparticles (in green). The endosomes – the part of the cell in which the nanoparticles release the vaccine – appear in blue (Photo courtesy of Bourquin Laboratory, University of Geneva).

Spider Silk Microparticle System Engineered for Anticancer Drugs

Engineered spider silk microparticles underlie a novel transport system for the delivery of immunotherapeutic drugs to critical stimulatory sites in the immune system. More...
25 Jun 2018
Image: In the transition from benign to malignant, cancer cells transition from stiff to soft. Mechanotargeting harnesses mechanics to improve targeting efficiency of nanoparticle-based therapeutic agents (Photo courtesy of the Zhang Laboratory, Pennsylvania State University).

Novel Method Designed to Destroy Only Malignant Cells

A novel system for targeted release of drugs to kill malignant cancer cells depends on the shape and mechanical properties of the cells rather than the presence of specific biomarker molecules. More...
24 Jun 2018
Image: Synthetic human prions accumulating in the brain of humanized transgenic mice (Photo courtesy of Case Western Reserve University School of Medicine).

Newly Created Prion Seen As Exciting Research Tool

A neurodegenerative disease research team has created an exciting new research tool by synthesizing a fully functional, infectious human prion, similar to that causing the fatal progressive neural disorder Creutzfeldt-Jakob disease. More...
20 Jun 2018
Image: Immunomodulatory signal presentation via synthetic hydrogel material promotes generation of T regulatory cells (green) in the local graft microenvironment (CD3+ T-cells in red, and nuclei staining in blue) after implantation into a clinically relevant transplant model for the treatment of type I diabetes (Photo courtesy of the Georgia Institute of Technology).

Immunosuppressing Microparticles Prevents Rejection of Transplanted Cells

A novel potential treatment approach for type I diabetes is based on transplantation of insulin-producing pancreatic islet cells together with synthetic hydrogel microparticles that contain the immune system modulator protein Fas ligand (FasL). More...
20 Jun 2018
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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