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BioResearch

Image: Genetically modified astrocytes (red) line the lesion border in the injured spinal cord. A new mouse study showed that triggering a gene inside astrocytes activated the star-shaped cells and may improve the brain’s ability to heal from a range of debilitating conditions, from stroke to concussions and spine injuries (Photo courtesy of Dr. Meifan Amy Chen, University of Texas Southwestern Medical Center).

Critical Brain Cell Repair Gene Identified in Study

Repair of damaged brain cells depends on the process of astrogliosis, which has been shown to be regulated by the MAP3K13 (also known as leucine zipper-bearing kinase [LZK]) gene. More...
10 Apr 2018
Image: Antibodies against APOE (red) bind to amyloid plaques (blue) in brain tissue from people with Alzheimer\'s disease. Investigators have found that the antibody can sweep away the damaging plaques, at least in mice, which could lead to a therapy for the devastating disease (Photo courtesy of Monica Xiong, Washington University School of Medicine).

Antibody Clears Amyloid Plaques in Mouse Model

A team of Alzheimer's disease researchers working with a mouse model identified a specific antibody capable of binding to and mediating the removal of the amyloid plaques that characterize this catastrophic neurodegenerative disorder. More...
10 Apr 2018
Image: A diagram of a 5-AZA resistant chromatin structure (Photo courtesy of Dr. Jason Cheng).

Role of RNA Methylation Defined in Drug Resistance by Leukemia Cells

Results of a recent study defined the roles of RNA 5-methylcytosine (RNA:m5C) and RNA:m5C methyltransferases (RCMTs) in the formation of discrete chromatin structures that modulate 5-Azacitidine (5-AZA) response or resistance in leukemia cells. More...
05 Apr 2018
Image: A family of economical silver-based complexes shows very promising results against a number of human cancers in laboratory tests, with very low toxicity in rat studies and minimal effects on healthy cells. One of these complexes, UJ3, is as effective as the industry-standard drug Cisplatin in killing cancer cells in laboratory tests done on human esophageal cancer, breast cancer, and melanoma. This matrix of light microscope images shows a comparison of human esophageal cancer cells treated with UJ3 and Cisplatin (Photo courtesy of Dr. Zelinda Engelbrecht, University of Johannesburg).

Less Toxic Drugs May Replace Current Chemotherapeutic Agents

A team of South African cancer researchers has suggested replacing the current frontline platinum-based chemotherapeutic drugs with first generation silver(I) phosphines, which have vast structural diversity and promising anticancer activity. More...
04 Apr 2018
Image: Ripe pecan-nuts photographed on a tree in Hadera, Israel (Photo courtesy of Wikimedia Commons).

Pecan-Enriched Diet Protects against CV Disease and Diabetes

Results of a randomized, controlled feeding trial suggested that eating just 1.5 ounces (44.36 milliliters) of pecans every day could protect adults at risk for developing cardiovascular disease (CVD) and type II diabetes. More...
03 Apr 2018
Image: The binding site of the amino acid transporter inhibitor UCPH101 was resolved by X-ray crystallography and was located at a distance from the substrate-binding site. In the image, the substrate is shown in the center of the transporter, while the inhibitor is located between the translocation and scaffold domain of the transporter (lower right). The inhibitor glues the two domains together, thereby inhibiting transport (Photo courtesy of Dr. Stefan Broer).

Review Article Summarizes Progress Towards Drug Development

A recent review article summarized the methods used to identify new inhibitors for amino acid transporters and outlined cell and organ function where these can be used to modulate, prevent, or to treat diseases. More...
02 Apr 2018
Image: A micrograph showing an array of nanospears prior to release for delivery of genetic information to cells (Photo courtesy of UCLA).

Nanospear Technology Developed for Directed Gene Therapy

A novel delivery system for macromolecular compounds such as genes depends on nanoscale splinter-like structures that have been termed "nanopsears." More...
29 Mar 2018
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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