We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App




Two Simple Serum Biomarkers Differentiate Lymphoma from Glioma

By LabMedica International staff writers
Posted on 22 Apr 2022
Print article
Image: Micrograph of brain tissue with glioma enlargement and disease histology (Photo courtesy of 123rf.com)
Image: Micrograph of brain tissue with glioma enlargement and disease histology (Photo courtesy of 123rf.com)

A recent study found that two simple serum biomarkers, absolute lymphocyte count and prognostic nutritional index, which are easily derived from routine pre-treatment blood tests, have fair correlation and acceptable diagnostic accuracy for differentiating primary central nervous system lymphoma (PCNSL) from high-grade glioma (HGG) in patients with similar morphology on MRI.

A complex series of interactions take place between cancer and inflammation that are reflected by increased release of inflammatory biomarkers into the bloodstream. However, the utility of systemic inflammatory biomarkers as a means for the noninvasive differential diagnosis of PCNSL from HCC is generally lacking.

To repair this lack, investigators at the Homi Bhabha National Institute (Mumbai, India) and their colleagues carried out a study that involved calculating systemic inflammatory indices from pre-treatment complete blood counts and liver function tests and comparing them against histopathology as the reference standard among 42 patients with PCNSL and 16 with HGG.

Results revealed that the area under the receiver operating characteristics curve for absolute lymphocyte count and prognostic nutritional index in the diagnosis of PCNSL was 0.70 and 0.72 respectively, which suggested that these markers yielded fair and acceptable diagnostic accuracy.

The investigators said, "This exploratory first-of-a kind study assessed the utility of systemic inflammatory biomarkers derived from routine blood investigations in a cohort of patients with suspected PCNSL to differentiate them reliably from HGG with similar morphologic imaging."

The study was published in the April 4, 2022, online edition of the journal CNS Oncology.

Related Links:
Homi Bhabha National Institute 

Gold Member
Fully Automated Cell Density/Viability Analyzer
BioProfile FAST CDV
Verification Panels for Assay Development & QC
Seroconversion Panels
New
Malondialdehyde HPLC Test
Malondialdehyde in Serum/Plasma – HPLC
New
Herpes Simplex Virus ELISA
HSV 2 IgG – ELISA

Print article

Channels

Clinical Chemistry

view channel
Image: QIP-MS could predict and detect myeloma relapse earlier compared to currently used techniques (Photo courtesy of Adobe Stock)

Mass Spectrometry-Based Monitoring Technique to Predict and Identify Early Myeloma Relapse

Myeloma, a type of cancer that affects the bone marrow, is currently incurable, though many patients can live for over 10 years after diagnosis. However, around 1 in 5 individuals with myeloma have a high-risk... Read more

Immunology

view channel
Image: The cancer stem cell test can accurately choose more effective treatments (Photo courtesy of University of Cincinnati)

Stem Cell Test Predicts Treatment Outcome for Patients with Platinum-Resistant Ovarian Cancer

Epithelial ovarian cancer frequently responds to chemotherapy initially, but eventually, the tumor develops resistance to the therapy, leading to regrowth. This resistance is partially due to the activation... Read more

Technology

view channel
Image: The HIV-1 self-testing chip will be capable of selectively detecting HIV in whole blood samples (Photo courtesy of Shutterstock)

Disposable Microchip Technology Could Selectively Detect HIV in Whole Blood Samples

As of the end of 2023, approximately 40 million people globally were living with HIV, and around 630,000 individuals died from AIDS-related illnesses that same year. Despite a substantial decline in deaths... Read more

Industry

view channel
Image: The collaboration aims to leverage Oxford Nanopore\'s sequencing platform and Cepheid\'s GeneXpert system to advance the field of sequencing for infectious diseases (Photo courtesy of Cepheid)

Cepheid and Oxford Nanopore Technologies Partner on Advancing Automated Sequencing-Based Solutions

Cepheid (Sunnyvale, CA, USA), a leading molecular diagnostics company, and Oxford Nanopore Technologies (Oxford, UK), the company behind a new generation of sequencing-based molecular analysis technologies,... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.