We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Technopath Clinical Diagnostics - An LGC Company

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Micro-Mechanical Blood Clot Testing Using Smartphones

By LabMedica International staff writers
Posted on 23 Feb 2022
Print article
Image: A new blood-clotting test that uses only a single drop of blood and a smartphone with a plastic attachment that holds a tiny cup beneath the phone’s camera (Photo courtesy of Mark Stone/University of Washington)
Image: A new blood-clotting test that uses only a single drop of blood and a smartphone with a plastic attachment that holds a tiny cup beneath the phone’s camera (Photo courtesy of Mark Stone/University of Washington)

Researchers have developed a new blood-clotting test that uses only a single drop of blood and a smartphone vibration motor and camera.

The human body responds to injury with bleeding, followed by clot formation and eventually lysis. This carefully maintained homeostasis minimizes the risks of hemorrhage and inappropriate clotting like ischemic stroke, myocardial infarction or pulmonary embolus.

Frequent prothrombin time (PT) and international normalized ratio (INR) testing is critical for millions of people on lifelong anticoagulation with warfarin. Currently, testing is performed in hospital laboratories or with expensive point-of-care devices limiting the ability to test frequently and affordably.

Medical Scientists at the University of Washington (Seattle, WA, USA) have described a proof-of-concept system that uses the vibration motor and camera on existing smartphones to perform PT/INR testing. Smartphones are increasingly becoming ubiquitous in resource-constrained environments and developing countries both in rural and urban settings. Vibration motors and cameras have been an integral part of smartphones for more than a decade. Repurposing these smartphone sensors for PT/INR testing could enable a more affordable blood clot testing tool.

In the new system a drop of blood is added to a small silicone cup, which contains a minute copper particle and a chemical that starts the blood-clotting process. Then the phone's vibration motor shakes the cup while the camera monitors the movement of the particle, which slows down and then stops moving as the clot forms. To calculate PT and INR, the phone collects two time stamps: first when the user inserts the blood and second when the particle stops moving.

The investigators designed a custom Android application on a Samsung Galaxy S9 to perform measurements. The vibration motor on the Samsung Galaxy S9 has a resonant frequency of 159 Hz. The motor was set to vibrate continuously while the camera recorded the clotting process. The camera had an ISO of 320, 1/60 shutter speed, 5500 K white balance and captured frames at the maximum frame rate. The scientists showed that this method falls within the accuracy range of the standard instruments of the field.

The team tested this method on three different types of blood samples. As a proof of concept, the team started with plasma, a component of blood that is transparent and therefore easier to test. They then tested plasma from 140 anonymized patients and also examined plasma from 79 patients with known blood-clotting issues. For both these conditions, the test had results that were similar to commercially available tests. To mimic what a patient at home would experience, the team then tested whole blood from 80 anonymized patients. This test also yielded results that were in the accuracy range of commercial tests.

Shyamnath Gollakota, PhD, an Associate Professor and senior author of the study, said, “Almost every smartphone from the past decade has a vibration motor and a camera. This means that almost everyone who has a phone can use this. All you need is a simple plastic attachment, no additional electronics of any kind. This is the best of all worlds; it's basically the holy grail of PT/INR testing. It makes it frugal and accessible to millions of people, even where resources are very limited.”

The authors concluded that given the ubiquity of smartphones in the global setting, this proof-of-concept technology may provide affordable and effective PT and INR testing in low-resource environments. The study was published on February 11, 2022 in the journal Nature Communications.

Related Links:
University of Washington 

Gold Supplier
Renin Control
Lumipulse Renin Control
New
Urine Analyzer
H-500
New
Silver Supplier
Monkeypox Virus Real Time PCR Test
Monkeypox Virus Real Time PCR Detection Kit
New
Blood Transfusion Safety Test
ABTest Card

Print article

Channels

Microbiology

view channel
Image: Trichinella sp. found in muscle tissue (Photo courtesy of McGill University)

Laboratory Features of Trichinellosis and Eosinophilia Threshold Determined

Trichinella nativa is a nematode worm, one of the species of the genus Trichinella, found in arctic and subarctic regions. It is highly pathogenic and has a high resistance to freezing. It is encapsulated,... Read more

Industry

view channel
Image: With Cell IDx’s acquisition, Leica Biosystems will be moving its multiplexing menu forward (Photo courtesy of Leica Biosystems)

Leica Biosystems Acquires Cell IDx, Expanding Offerings in Multiplexed Tissue Profiling

Leica Biosystems, a technology leader in automated staining and brightfield and fluorescent imaging (Nussloch, Germany), has acquired Cell IDx, Inc. (San Diego, CA, USA), which provides multiplex staining... Read more
Copyright © 2000-2022 Globetech Media. All rights reserved.