We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




CSF Analyzed in Lung Cancer with Brain Metastases

By LabMedica International staff writers
Posted on 29 Nov 2017
The analysis of mutations in cerebrospinal fluid of lung cancer patients with brain metastases has been explored. More...
Tumor tissue from brain metastasis is difficult to obtain and therefore less invasive methods are needed to identify and monitor the presence of known actionable mutations.

Brain metastases are a frequent complication of non-small cell lung cancer (NSCLC), especially in patients with lung adenocarcinoma. Patients with epidermal growth factor receptor (EGFR) mutations benefit from EGFR tyrosine kinase inhibitors (TKIs), but most relapse within one or two years, many with brain metastases.

A team of scientists working with those at Zhengzhou University (Zhengzhou City, China) compared EGFR mutation status in blood and cerebrospinal fluid and their relationship to neurological symptoms and leptomeningeal metastases. The study included 41 lung adenocarcinoma patients with EGFR mutations and brain metastases. EGFR mutation status was analyzed in the blood of 37 patients and cerebrospinal fluid of all patients. The presence of leptomeningeal metastases was assessed with magnetic resonance imaging (MRI).

The investigators found that in the entire study population, the rate of EGFR mutations in blood (65%) was significantly higher than in cerebrospinal fluid (37%). Eleven patients had leptomeningeal metastases detected by MRI. The rate of EGFR mutations in cerebrospinal fluid was significantly higher in patients with leptomeningeal metastases (73%) than in those without leptomeningeal metastases (23%). Neurological symptoms were present in 27 patients and the rate of EGFR mutations in cerebrospinal fluid was significantly higher in patients with neurological symptoms (48%) than in those without symptoms (14%).

Stefan Zimmermann, MD, a Medical Oncologist at Lausanne University Hospital (Lausanne, Switzerland) said, “Genotyping of cell-free DNA using droplet digital polymerase chain reaction (PCR) in cerebrospinal fluid as a less invasive modality to identify and monitor the presence of known actionable mutations is certainly interesting, as tumor tissue from brain metastasis is difficult to obtain.” There is now a consensus among global experts that liquid biopsy using blood samples should be used to test for T790M and EGFR mutations in patients with NSCLC when tumor tissue is not available. The study was presented at the European Society for Medical Oncology Asia 2017 Congress held November 17-19, 2017, in Singapore.

Related Links:
Zhengzhou University
Lausanne University Hospital

New
Gold Member
Quality Control Material
iPLEX Pro Exome QC Panel
3-Part Differential Hematology Analyzer
Swelab Alfa Plus Sampler
New
DNA/RNA Extraction/Purification Kit
Nucleic Acid Extraction or Purification Kit
New
Automated Microscope
dIFine
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








DIASOURCE (A Biovendor Company)

Channels

Molecular Diagnostics

view channel
Image: The RNA-seq based diagnostic test for pediatric leukemia ensures better outcomes for children with this common cancer (Photo courtesy of Qlucore)

RNA-Seq Based Diagnostic Test Enhances Diagnostic Accuracy of Pediatric Leukemia

A new unique test is set to reshape the way Acute Lymphoblastic Leukemia (BCP-ALL) samples can be analyzed. Qlucore (Lund, Sweden) has launched the first CE-marked RNA-seq based diagnostic test for pediatric... Read more

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Immunology

view channel
Image: A simple blood test could replace surgical biopsies for early detecion of heart transplant rejection (Photo courtesy of Shutterstock)

Blood Test Detects Organ Rejection in Heart Transplant Patients

Following a heart transplant, patients are required to undergo surgical biopsies so that physicians can assess the possibility of organ rejection. Rejection happens when the recipient’s immune system identifies... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.