Novel Saliva Test Identifies and Tracks Cancer

The EFIRM device analyzes the contents of exosomes which are tiny bags of molecules that cells release now and again. The device forces the exosomes to release their contents and carries out bio-recognition of the released biomolecules at the same time, and the method is high accurate compared with current sequencing technology.

The test works by detecting genetic mutations in a protein called epidermal growth factor receptor (EGFR). The protein normally helps cells grow and divide, but some NSCLC cells have too much EGFR, which makes them grow faster. Drugs called EGFR inhibitors that block the protein could be ordered promptly by a clinician. The key finding came from a blind and randomized clinical study that used saliva samples procured from lung cancer patients. Using the EFIRM method to detect two key tumor-causing mutations in the EGFR gene (L858R and exon 19 deletion) in saliva, the investigators achieved nearly identical results as with bronchoscopy-based detection of the same two mutations.

Their findings have significant implications in the quest to develop more effective, noninvasive, reliable early detection testing for lung cancer mutations. Furthermore, EFIRM testing has the potential to show how the body is reacting to cancer therapeutics and whether those therapeutics need to be adjusted to improve a patient’s response.

David T.W. Wong, DMD, DMSc, Director for UCLA Center for Oral/Head & Neck Oncology Research, who led the study, sees the test forming part of a set of diagnostic tools. For example, should a lung X-ray show a suspicious nodule, and then the doctor could use the saliva test to rapidly find out if cancer is likely. The study was presented at the 2016 Annual Meeting of the American Association for the Advancement of Science that was held February 11–15, 2016, in Washington DC (USA).

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