We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




Blood Test Could Provide Snapshot of Overall Health

By LabMedica International staff writers
Posted on 09 Jul 2024
Print article
Image: Proteomic analysis of cardiorespiratory fitness for prediction of mortality and multisystem disease risks (Photo courtesy of Perry, A.S., Farber-Eger, E., Gonzales, T. et al.; doi.org/10.1038/s41591-024-03039-x)
Image: Proteomic analysis of cardiorespiratory fitness for prediction of mortality and multisystem disease risks (Photo courtesy of Perry, A.S., Farber-Eger, E., Gonzales, T. et al.; doi.org/10.1038/s41591-024-03039-x)

Cardiorespiratory fitness significantly influences various bodily systems, from metabolism to brain function. Currently, there is no standardized method to quantitatively assess cardiorespiratory fitness, even though it provides a comprehensive view of a person’s health. Now, a new study has found that levels of circulating proteins could be effective biomarkers for cardiorespiratory fitness, a crucial but previously difficult-to-quantify component of an individual’s overall health.

In the study published in Nature Medicine, investigators at Northwestern University Feinberg School of Medicine (Chicago, IL, USA) used statistical models to identify circulating proteins that most significantly affect overall health across over 14,000 participants. The researchers developed a cardiorespiratory fitness score based on an individual's levels of certain circulating proteins, which are linked to inflammation, neuronal survival and growth, and oxidative stress, among other factors. This scoring system was then validated using data from 20,000 individuals in the UK Biobank, revealing that a favorable score correlates with a lower risk of all-cause mortality.

The team further tested the validity of their scoring system by analyzing the circulating proteins of over 600 individuals before and after they participated in a 20-week exercise program. The study found that improvements in participants' cardiorespiratory fitness scores were associated with the beneficial impacts of exercise on their cardiorespiratory systems. These results establish a foundation for a scoring system that could potentially assess holistic health through a simple blood test, offering insights into the relationship between fitness and health. Building on this, the researchers plan to extend this protein scoring method to additional areas of overall health.

“We know a lot about trajectories of health. Someone might be on a declining trajectory, but when we see patients at one time point, it’s really hard for us to extrapolate what a trajectory of someone’s health may be,” said Ravi Kalhan, MD, MS, professor of Medicine in the Division of Pulmonary and Critical Care, of Preventive Medicine in the Division of Epidemiology, and a co-author of the study. “If we could apply these single-time-point measurements using a blood test that reflects a greater, more difficult-to-ascertain factor of health, that really would be interesting.”

Related Links:
Northwestern University Feinberg School of Medicine

New
Platinum Member
Flu SARS-CoV-2 Combo Test
OSOM® Flu SARS-CoV-2 Combo Test
Magnetic Bead Separation Modules
MAG and HEATMAG
Complement 3 (C3) Test
GPP-100 C3 Kit
Gold Member
Liquid Ready-To-Use Lp(a) Reagent
Lipoprotein (a) Reagent

Print article
77 ELEKTRONIKA

Channels

Clinical Chemistry

view channel
Image: PhD student and first author Tarek Eissa has analyzed thousands of molecular fingerprints (Photo courtesy of Thorsten Naeser / MPQ / Attoworld)

Screening Tool Detects Multiple Health Conditions from Single Blood Drop

Infrared spectroscopy, a method using infrared light to study the molecular composition of substances, has been a foundational tool in chemistry for decades, functioning similarly to a molecular fingerprinting... Read more

Hematology

view channel
Image: The Truvian diagnostic platform combines clinical chemistry, immunoassay and hematology testing in a single run (Photo courtesy of Truvian Health)

Automated Benchtop System to Bring Blood Testing To Anyone, Anywhere

Almost all medical decisions are dependent upon laboratory test results, which are essential for disease prevention and the management of chronic illnesses. However, routine blood testing remains limited worldwide.... Read more

Microbiology

view channel
Image: The Simplexa C. auris direct kit is a real-time polymerase chain reaction assay run on the LIAISON MDX instrument (Photo courtesy of Diasorin)

Novel Molecular Test to Help Prevent and Control Multi Drug-Resistant Fungal Pathogen in Healthcare Settings

Candida auris (C. auris) is a rapidly emerging multi drug-resistant fungal pathogen that is commonly found in healthcare environments, where it presents a challenge due to its ability to asymptomatically... Read more

Pathology

view channel
Image: The tool can improve precision oncology by accurately predicting molecular subtypes and therapy responses (Photo courtesy of Shutterstock)

Computational Tool Integrates Transcriptomic Data for Improved Breast Cancer Diagnosis and Treatment

Breast cancer is the most commonly diagnosed cancer globally, presenting in various subtypes that require precise identification for effective, personalized treatment. Traditionally, cancer subtyping has... Read more

Industry

view channel
Image: Beckman Coulter will utilize the ALZpath pTau217 antibody to detect key biomarker for Alzheimer\'s disease on its DxI 9000 immunoassay analyzer (Photo courtesy of Beckman Coulter)

Beckman Coulter Licenses Alzpath's Proprietary P-tau 217 Antibody to Develop Alzheimer's Blood Test

Cognitive assessments have traditionally been the primary method for diagnosing Alzheimer’s disease, but this approach has its limitations as symptoms become apparent only after significant brain changes... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.