We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us

Download Mobile App




Large Proteomics Study Identifies New Fluid Biomarkers for Diagnosis of Alzheimer’s Disease

By LabMedica International staff writers
Posted on 22 Apr 2020
A recent study identified proteins and biological processes in brains from Alzheimer’s disease (AD) that may serve as diagnostic fluid biomarkers and potential therapeutic targets for the disease.

Investigators at Emory University (Atlanta, GA, USA) and colleagues at the [U.S.] National Institute on Aging (Bethesda, MD, USA) and other institutions used quantitative mass spectrometry and coexpression network analysis to conduct the largest proteomic study thus far on AD.

For this study, the investigators analyzed patterns of protein expression in more than 2,000 human brain and nearly 400 cerebrospinal fluid samples from both healthy individuals and patients diagnosed with Alzheimer's disease. More...
Brain tissue samples came from autopsy of participants in AD research centers and several epidemiological studies across the country. The brain collections also contained samples from individuals with six other neurodegenerative disorders as well as samples representing normal aging. Cerebrospinal fluid samples were collected from study participants at the Emory University Goizueta Alzheimer's Disease Research Center.

Results of the study pointed to a protein network module linked to sugar metabolism as being one of the modules most significantly associated with AD pathology and cognitive impairment. This module was enriched in AD genetic risk factors and in microglia and astrocyte protein markers associated with an anti-inflammatory state, suggesting that the biological functions it represents serve a protective role in AD. Proteins from this module were found to be elevated in cerebrospinal fluid in early stages of the disease.

"We have been studying the possible links between abnormalities in the way the brain metabolizes glucose and Alzheimer's-related changes for a while now," said contributing author Dr. Madhav Thambisetty, chief of the clinical and translational neuroscience section at the NATIONAL INSTITUTE ON AGING. "The latest analysis suggests that these proteins may also have potential as fluid biomarkers to detect the presence of early disease."

The Alzheimer’s disease proteomics study was published in the April 13, 2020, online edition of the journal Nature Medicine.

Related Links:
Emory University
National Institute on Aging



New
Gold Member
Cardiovascular Risk Test
Metabolic Syndrome Array I & II
Collection and Transport System
PurSafe Plus®
New
Alcohol Testing Device
Dräger Alcotest 7000
New
Pipette
Accumax Smart Series
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Hematology

view channel
Image: New research points to protecting blood during radiation therapy (Photo courtesy of 123RF)

Pioneering Model Measures Radiation Exposure in Blood for Precise Cancer Treatments

Scientists have long focused on protecting organs near tumors during radiotherapy, but blood — a vital, circulating tissue — has largely been excluded from dose calculations. Each blood cell passing through... Read more

Immunology

view channel
Image: The VENTANA HER2 (4B5) test is now CE-IVDR approved (Photo courtesy of Roche)

Companion Diagnostic Test Identifies HER2-Ultralow Breast Cancer and Biliary Tract Cancer Patients

Breast cancer is the most common cancer in Europe, with more than 564,000 new cases and 145,000 deaths annually. Metastatic breast cancer is rising in younger populations and remains the leading cause... Read more

Pathology

view channel
Image: An adult fibrosarcoma case report has shown the importance of early diagnosis and targeted therapy (Photo courtesy of Sultana and Sailaja/Oncoscience)

Accurate Pathological Analysis Improves Treatment Outcomes for Adult Fibrosarcoma

Adult fibrosarcoma is a rare and highly aggressive malignancy that develops in connective tissue and often affects the limbs, trunk, or head and neck region. Diagnosis is complex because tumors can mimic... Read more

Technology

view channel
Image: Conceptual design of the CORAL capsule for microbial sampling in the small intestine (H. Mohammed et al., Device (2025). DOI: 10.1016/j.device.2025.100904)

Coral-Inspired Capsule Samples Hidden Bacteria from Small Intestine

The gut microbiome has been linked to conditions ranging from immune disorders to mental health, yet conventional stool tests often fail to capture bacterial populations in the small intestine.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.