We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
DxGen

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
24 Feb 2021 - 28 Feb 2021
Virtual Venue
03 Mar 2021 - 05 Mar 2021
Virtual Venue

Proteomics-Based Diagnostic Test Predicts Risk of Dying from Staphylococcus aureus Bacteremia

By LabMedica International staff writers
Posted on 14 Sep 2020
Print article
Image: Using advanced biochemical analysis of patient serum, researchers found signatures that help predict which patients are at highest risk of dying from S. aureus bacteremia, a blood infection (Photo courtesy of University of California, San Diego)
Image: Using advanced biochemical analysis of patient serum, researchers found signatures that help predict which patients are at highest risk of dying from S. aureus bacteremia, a blood infection (Photo courtesy of University of California, San Diego)
A diagnostic approach that integrates proteomic and metabolomic techniques enabled the identification of biomarkers that could predict which patients had the highest risk of dying from Staphylococcus aureus bacteremia.

Staphylococcus aureus bacteremia (SaB) causes significant disease in humans, carrying mortality rates of nearly 25%. The ability to rapidly predict SaB patient responses and guide personalized treatment regimens could reduce mortality.

In order to develop this predictive capability, investigators at the University of California, San Diego (USA) utilized mass spectrometry (MS) to analyze more than 10,000 proteins and metabolites present in more than 200 serum samples collected from the blood of patients with SaB.
Gold Supplier
Virus Transport and Preservation Medium – Inactivated
Virus Transport and Preservation Medium – Inactivated
COVID-19 and Influenza Test
COVID-19 and Influenza A+B Antigen Combo Rapid Test
Visit expo >

Results revealed that by integrating proteomic and metabolomic techniques, the investigators could identify more than 10,000 features from serum samples collected upon clinical presentation. The MS results demonstrated a specific pattern of proteins with and without post-translational modifications that differed in the serum of patients who ultimately died of SaB compared to those who did not. The biomarkers most highly associated with death included lower levels of glycosylated fetuin A, unmodified fetuin B, and thyroxine.

With the area under the curve (AUC) higher than 0.95, the biomarkers identified in this study greatly exceeded the predictive capabilities of those previously reported, particularly when used in combination.

"This finding is a leap forward toward a point-of-care predictive tool for bacteremia risk," said senior author Dr. David Gonzalez, assistant professor of medicine at the University of California, San Diego. "It also opens up lots of new basic biological questions about how our immune systems respond to infections. If I wanted to learn all about you, I would just talk to you directly, not your second cousin. Same thing here - we can gain new and important information by directly "asking" the proteins, rather than their genes, and mass spectrometry is currently the best way to do that in an unbiased manner."

The study was published in the September 3, 2020, online edition of the journal Cell.

Related Links:
University of California, San Diego


Print article

Channels

Pathology

view channel
Image: The Leica Bond III stainer is fully automated Immunohistochemical and In Situ Hybridization (IHC and ISH stainer) (Photo courtesy of Leica Biosystems).

Mismatch Repair/Microsatellite Instability Evaluated Using Cytology Effusion Specimens

DNA mismatch repair (MMR) status is routinely assessed in colorectal and endometrial carcinoma as a method of cancer prevention, surveillance in patients with Lynch syndrome and their families, and for... Read more

Industry

view channel
Illustration

Roche Renews Partnership with Sysmex to Deliver Hematology Testing Solutions

Under the new framework of a Global Business Partnership Agreement (GBP) signed between Roche (Basel, Switzerland) and Sysmex Corporation (Kobe, Japan), both the companies have renewed their commitment... Read more
Copyright © 2000-2021 Globetech Media. All rights reserved.