We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App




Biomarkers Linked to Fatigue in Parkinson’s Disease

By LabMedica International staff writers
Posted on 21 Aug 2018
Parkinson's disease (PD) is a long-term degenerative disorder of the central nervous system that mainly affects the motor system. More...
The symptoms generally come on slowly over time. Early in the disease, the most obvious are shaking, rigidity, slowness of movement, and difficulty with walking.

The cause of Parkinson's disease is generally unknown, but believed to involve both genetic and environmental factors. There is no cure for Parkinson's disease, with treatment directed at improving symptoms. Parkinson's disease (PD) ‐related fatigue is a significant clinical problem, and the pathological processes that cause fatigue remain unknown.

An international team of scientists led by Rice University staff (Houston, TX, USA) included in a study 47 drug naïve, newly diagnosed PD patients with low (≤3.0) or high (>5.5) fatigue levels as evaluated by the Fatigue Severity Scale (FSS). Strict diagnostic criteria were applied for inclusion. Patients with possible confounding causes for fatigue were excluded.

Serum concentrations of a panel of inflammatory markers including interleukin-8 (IL‐8), IL‐6, IL‐6R, IL1‐Ra, Tumor necrosis factor alpha (TNF‐α), tumor necrosis factor receptor 1 (TNFR1) Monocyte chemoattractant protein 1, (MCP1), macrophage inflammatory protein (MIP‐1β), p‐selectin, E‐selectin‐1, Intercellular Adhesion Molecule 1 (ICAM), Vascular Cell Adhesion Protein 1 (VCAM‐1), and Chemokine (C-C motif) ligand 5 (CCL5), measured using enzyme-linked immunosorbent assay (ELISA) technology in PD patients with and without fatigue to assess the potential relationships of fatigue in newly diagnosed, treatment‐naïve patients.

The scientists reported that fatigued PD patients had significantly higher levels of the IL‐1 receptor antagonist (IL1‐Ra) (1,790 pg/mL ± 1,007) versus 1,262 pg/mL ± 379) and of the adhesion molecule VCAM 1 (1,071 ng/mL ± 276 versus 895 ng/mL ± 229) than non‐fatigued patients. The authors concluded that higher serum levels of the inflammatory molecules IL1‐Ra and VCAM‐1 were associated with higher fatigue levels in patients with newly diagnosed, drug‐naïve PD. These findings highlight an altered immune response as a potential contributor to PD‐related fatigue, from the earliest clinical stages of the disease. The study was published online on June 26, 2018, in the journal Acta Neurologica Scandinavica.

Related Links:
Rice University


New
Gold Member
Latex Test
SLE-Latex Test
Serological Pipet Controller
PIPETBOY GENIUS
New
Pan-Cancer Panel
TruSight Oncology 500
New
PSA Assay
CanAg PSA EIA
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Pathology

view channel
These images illustrate how precision oncology Organ Chips recapitulate individual patients’ responses to chemotherapy (Photo courtesy of Wyss Institute at Harvard University)

Cancer Chip Accurately Predicts Patient-Specific Chemotherapy Response

Esophageal adenocarcinoma (EAC), one of the two primary types of esophageal cancer, ranks as the sixth leading cause of cancer-related deaths worldwide and currently lacks effective targeted therapies.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.