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白细胞计数预测肾脏疾病预后

By LabMedica International staff writers
Posted on 08 Jul 2011
血液中淋巴细胞数或许可用作肾细胞癌(RCC)的一个预后指标。

淋巴细胞是白细胞的一种,在临床实验室中可通过常规方法计数,数目少可能意味着免疫系统受到抑制。

来自美国宾夕法尼亚州费城Fox Chase癌症中心(www.fccc.edu)的医疗肿瘤专家对500多名最常见RCC亚型——透明细胞RCC患者的数据进行了评估,这些患者于1994年至2009年间在Fox Chase癌症中心接受了肾脏摘除手术。专家发现,手术前三个月内的低淋巴细胞计数与预后不良存在明确关系。

科学家们发现较低的淋巴细胞水平往往伴随着较高的肿瘤等级、较晚的病理肿瘤分期、远处转移以及较高的恶性肿瘤(TNM)分期, TNM分期是一种评估肿瘤分期、扩散至局部淋巴结和远处转移的复合指标。他们还发现低计数与较低的总体存活率存在关联,即便考虑患者年龄、肿瘤分期和转移的影响也是如此。

研究论文的第一作者、Fox Chase癌症中心的医疗肿瘤研究员Sunil Saroha医学博士称:“一直以来,研究人员都希望找到可用于术前预后的标志物。最好能够在术前了解肿瘤是否会恶化,以及我们需要采用何种程度的治疗手段,而根本目的在于实现个性化治疗。”这一简单测试可以真正有助于在术前确定患者是否存在极高恶化风险以及当前疗法是否可能效果不佳。

在美国,每年近六万人被诊断为肾癌,其中许多患者会通过手术摘除病变的肾,但此过程对老年患者以及存在其它健康问题的患者相当危险。不幸的是,在手术摘取肿瘤样本并进行评估之前肾癌患者的预后常难以确定。例如,对于淋巴细胞计数并不低甚至可能相当健康的RCC年轻患者,医生可能会决定不施行更加激进的疗法,如手术和化疗。这项研究在2011年6月5日于美国伊利诺伊州芝加哥市举办的美国临床肿瘤学会年会上作了通报。

Related Links:
Fox Chase Cancer Center >>> www.fccc.edu
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