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靶向荧光成像化合物可检测癌症活细胞

By LabMedica International staff writers
Posted on 16 Jun 2009
荧光成像化合物只有当它在活体细胞内部时才起作用,而当细胞死亡或受到破坏后将不在产生荧光。通过对这种化合物进行工程设计,可以使其靶向特定类型的癌细胞。

这种新型化合物使得科学家能够可视化扩散导老鼠肺部的乳腺癌细胞。这种化合物可结合存在于某些乳腺癌细胞表面的名为HER2的蛋白质,只有当化合物进入到活体细胞内部时才发出荧光。这种靶向和激活方法使得科学家能够在乳腺癌的老鼠模型中检测特定类型的活体癌细胞

以前开发的可在人体细胞中被激活的荧光化合物的局限性是,一旦开始发出荧光后就将持续发光,甚至在它们散布到新位置后也是如此。 这就非常难以将活肿瘤细胞与正常组织、死亡、或受损的肿瘤细胞区分开。

研究工作是在日本和隶属美国国家卫生研究所(Bethesda, MD, USA; www.nih.gov)的国家癌症研究所(NCI)进行的。开发出成像化合物的科研组由来自国家癌症研究所癌症研究中心(CCR)的Hisataka Kobayashi博士领导,同时与东京大学(Japan; (www.u-tokyo.ac.jp)的Yasuteru Urano博士合作。

"通过可视化药物是否击中其目标以及击中目标后是否可导致肿瘤缩小,这些(荧光成像)化合物或许可使得医生能够监视病人对癌症疗法的反应。"Kobayashi博士说。他又补充说:"与其它可激活的荧光化合物不同,我们的这种化合物包括独立起作用的一种目标药剂和一种发荧光的药剂。通过使用与细胞表面蛋白质结合后被靶向细胞内化的任何抗体或分子,我们可以使荧光药剂靶向任何不同类型的癌细胞。"

描述这种新化合物的论文发表在2008年12月7号的《自然药物》在线版。

Related Links:

美国卫生研究所
www.nih.gov
东京大学
www.u-tokyo.ac.jp
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