We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App





New Molecular Clamping Technology Rapidly Detects Raging New SARS-CoV-2 Variants

By LabMedica International staff writers
Posted on 23 Apr 2021
A new molecular clamping technology that rapidly detects raging new SARS-CoV-2 variants has demonstrated enhanced sensitivity and specificity in a new study.

The findings demonstrated enhanced sensitivity and specificity using DiaCarta Inc.’s (Richmond, CA, USA) proprietary XNA-based molecular clamping technology that uses innovative synthetic Xenonucleic acid molecular oligomers (XNA) which hybridize with target wild-type DNA sequences, acting as molecular clamps, to enable the accurate amplification of mutant sequences only, using quantitative real-time polymerase chain reactions (qPCR).

In the study, a total of 278 previously tested SARS-CoV-2 positive samples, originating primarily from the San Francisco Bay Area, were analyzed. More...
The SARS-CoV-2 Spike-gene D614G mutation was detected in 58 of the 139 samples collected in January 2021 (41.7%) and in 78 of the 139 samples collected in February (56.1%). Notably, while the N501Y mutation was not detected in the samples from January, seven of the February samples tested positive for both the N501Y and D614G mutations. The results suggest a relatively recent and rampant spreading of the UK variant (B.1.1.7) in Northern California. The new molecular clamping technology is highly sensitive and specific and can accelerate large scale testing for SARS-CoV-2 variants to fight the global pandemic.

"Next generation sequencing (NGS) has been the standard method of detection for SARS-CoV-2 variants. However, the NGS-based assays are expensive, time consuming and not widely available, thereby limiting their utility in large scale surveillance for SARS-CoV-2 variants," said Michael Sha, Ph.D., Chief Technology Officer and Senior Vice President of R&D at DiaCarta Inc. "There has been an urgent need for testing platforms that can detect these variants rapidly and cost-effectively. This study demonstrates that DiaCarta's XNA technology can do both - accurately detect known and emerging SARS-CoV-2 mutations and provide a rapid, cost-effective solution for SARS-CoV-2 variant surveillance."

Related Links:
DiaCarta Inc.


Gold Member
SARS-CoV-2 Reactive & Non-Reactive Controls
Qnostics SARS-CoV-2 Typing
3-Part Differential Hematology Analyzer
Swelab Alfa Plus Sampler
New
Automated PCR Setup
ESTREAM
New
Pan-Cancer Panel
TruSight Oncology 500
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








DIASOURCE (A Biovendor Company)

Channels

Hematology

view channel
Image: CitoCBC is the world first cartridge-based CBC to be granted CLIA Waived status by FDA (Photo courtesy of CytoChip)

Disposable Cartridge-Based Test Delivers Rapid and Accurate CBC Results

Complete Blood Count (CBC) is one of the most commonly ordered lab tests, crucial for diagnosing diseases, monitoring therapies, and conducting routine health screenings. However, more than 90% of physician... Read more

Immunology

view channel
Image: A simple blood test could replace surgical biopsies for early detecion of heart transplant rejection (Photo courtesy of Shutterstock)

Blood Test Detects Organ Rejection in Heart Transplant Patients

Following a heart transplant, patients are required to undergo surgical biopsies so that physicians can assess the possibility of organ rejection. Rejection happens when the recipient’s immune system identifies... Read more

Pathology

view channel
Image: Pancreatic cancer diagnosis (Photo courtesy of World Journal of Gastroenterology)

AI-Driven Preliminary Testing for Pancreatic Cancer Enhances Prognosis

Pancreatic cancer poses a major global health threat due to its high mortality rate, with 467,409 deaths and 510,992 new cases reported worldwide in 2022. Often referred to as the "king" of all cancers,... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.