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Hematology

Image: TruSight Oncology 500 is a next-generation sequencing (NGS) assay that enables in-house comprehensive genomic profiling of tumor samples it accurately measures key current immuno-oncology biomarkers: microsatellite instability (MSI) and tumor mutational burden (TMB) (Photo courtesy of Illumina).

Next Generation Sequencing Finds More Gene Mutations for Leukemia

Myeloid malignancies are characterized by uncontrolled proliferation and/or defects in differentiation of abnormal myeloid progenitor cells. Myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPNs) are often thought to be precursors to a higher grade myeloid malignancies, namely acute myeloid leukemia (AML). More...
18 Feb 2021
Image: The Z2 Coulter Counter Analyzer can be used to analyze virtually any cell type and species variation (Photo courtesy of Beckman Coulter).

Biomarker Predicts Pancreatic Cancer Patients’ Response to CD40 Immunotherapy

Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer and currently the third leading cause of cancer deaths in the USA. Despite the fact that it only accounts for about 3% of new cancer cases, it is responsible for more than 7% of all cancer deaths, and only10% of patients survive five years with the disease. More...
17 Feb 2021
DIASOURCE (A Biovendor Company)
Image: The DxH 800 hematology analyzer, can utilize accurate data about individual cell size, shape and structure to provide high-quality first-pass results with VCS technology (Photo courtesy of Beckman Coulter Inc).

Automated Leucocyte VCS Parameters Evaluated for Pathogenic Infections

 Malaria and dengue are highly endemic in most parts of India. Mangalore, a city in coastal Karnataka, India, has high prevalence of both these vector‐borne infections with extensive range of clinical presentations. The outbreak of these infections is common during and after the rainy season. More...
16 Feb 2021
Image: The Technothrombin TGA is a thrombin generation assay (TGA) based on monitoring the formation of thrombin by means of a fluorogenic substrate upon activation of the coagulation cascade by tissue factor (Photo courtesy of Technoclone).

TFP Inhibitor Levels Elevated in Bleeding Tendency Patients

Mild to moderate bleeding disorders (MBDs) are characterized by symptoms such as epistaxis, easy bruising, or menorrhagia, but bleeding can also be severe under certain circumstances such as hemorrhage after surgery or birth. More...
11 Feb 2021
Image: Human erythrocytes showing variation in red cell distribution width (RDW), known as anisocytosis, higher levels may predict mortality in COVID-19 patients (Photo courtesy of Dr. Graham Beards)

RDW Levels Associated with Adverse Outcomes in COVID-19 Patients

The red cell distribution width (RDW) blood test measures the amount of red blood cell variation in volume and size. RDW is not used as an isolated parameter when interpreting a complete blood count (CBC); instead, it provides shades of meaning in the context of the hemoglobin (Hgb) and mean corpuscular value (MCV). More...
04 Feb 2021
Image: False-colored electron microscopic image of Bifidobacterium that are one of the major genera of bacteria that make up the gastrointestinal tract and are associated with variants in the lactase gene locus (Photo courtesy of The Keck Science Department of the Claremont Colleges)

ABO Histo-Blood Groups Influence Makeup of Gut Microbiome

Recent genome-wide association studies yielded inconsistent, underpowered and rarely replicated results such that the role of human host genetics as a contributing factor to microbiome assembly and structure remains uncertain. More...
01 Feb 2021
Image: The Cyan ADP flow cytometer (Photo courtesy of Beckman Coulter).

Specific RUNX1 Mutations Cause Different Disease Types

Mutations of the hematopoietic master regulator RUNX1 are associated with acute myeloid leukemia, familial platelet disorder and other hematological malignancies whose phenotypes and prognoses depend upon the class of the RUNX1 mutation. More...
28 Jan 2021
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.

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