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Hematology

Image: Bone marrow aspirate of a patient with myeloid leukemia associated with Down’s syndrome. The smear includes frequent atypical megakaryocytes. Blasts are increased (11%). As in the peripheral blood, a subset of the blasts has cytoplasmic blebs (Photo courtesy of Elizabeth L. Courville, MD).

Genetic Changes Linked to Leukemia in Down’s Syndrome Children

Of the 30% of children with Down's syndrome who are found to have 'myeloid preleukemia', only 10% of those will go on to develop myeloid leukemia (3% of all children with Down's syndrome). Until now, it was not understood why only some children with the GATA1 mutation were progressing to full leukemia, while others were not. More...
24 Jul 2019
Image: An immunoglobulin G (IgG)-induced neutrophil activation pathway contributes to human drug-induced anaphylaxis (Photo courtesy of Institut Pasteur).

Immunoglobulins and Neutrophils Play Unexpected Role in Anaphylaxis

Anaphylaxis may be brought about by various substances, including drugs (antibiotics or neuromuscular blocking agents), food and insect venom. Anaphylaxis is a hyperacute allergic reaction caused by an inappropriate immune response following the introduction of a usually harmless antigen into the body. More...
23 Jul 2019
Image: The ABL800 FLEX blood gas analyzer (Photo courtesy of Radiometer Medical).

Neutrophil‐Lymphocyte Ratio and Lactate Predict Mortality in Septic Patients

Sepsis is the primary cause of death from infection. It is also one of the leading causes of intensive care unit (ICU) mortality, despite early administration of antibiotics and hemodynamic management. More...
23 Jul 2019
Image: Defective Selection of Autoreactive B Cells seen in Systemic Lupus Erythematosus (Photo courtesy of Sebastian Kaulitzki).

Early B Cell Differentiation Activation Seen in Lupus

In people with systemic lupus erythematosus, their B cells, part of the immune system, are abnormally activated. They produce antibodies that react against their own tissues, causing a variety of symptoms, such as fatigue, joint pain, skin rashes and kidney problems. More...
17 Jul 2019
Image: A photomicrograph of an unstained, formalin preserved stool specimen mount, revealed the presence of a Paragonimus westermani trematode egg. Human infections of this lung fluke are most common in eastern Asia and in South America (Photo courtesy of the CDC).

Antibody Tests Recommended for Parasitic Infection Diagnosis

Pleural parasitic infestation (PPI) is a disease prevalent in certain parts of the world and it is frequently misdiagnosed due to its lack of standardized diagnostic criteria. The clinical manifestations are non-specific and many patients are initially treated for tuberculosis or misdiagnosed as lung cancer. More...
16 Jul 2019
Image: A bone marrow aspirate from a patient suffering from Hemophagocytic Lymphohistiocytosis showing a macrophage that has ingested a nucleated red cell (Photo courtesy of UF).

Dengue Infection Complicated by Hyperinflammatory Condition

The global incidence of dengue infection has grown dramatically and been estimated to 390 million infections yearly. This mosquito-borne virus infection occasionally develops into a potentially lethal state called severe dengue (SD). More...
11 Jul 2019
Image: The risk of thromboembolic and bleeding outcomes following hematological cancers is very high (Photo courtesy of the University of Warwick).

Thromboembolic Risk Increases after Hematological Cancers

Hematological cancer includes leukemia, bone marrow cancer and cancers of the lymph nodes. Therapeutic advances have improved survival after hematological cancers. In turn, patients may be at increased risk of thromboembolic and bleeding events. More...
09 Jul 2019
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.

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