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Hematology

Image: A scanning electron micrograph (SEM) showing long sickle cell in front of more disc-shaped normal red cell (Photo courtesy of the Wellcome Trust).

Infections Identified in Pediatric Sickle Cell Disease

Sickle cell anemia is a hereditary disorder of autosomal recessive inheritance that is characterized by sickle-shaped red blood cells. It is the most common type of hemoglobinopathy and is the result of a mutation in the β-globin chain gene that results in creating sickle hemoglobin (HbS) instead of the normal adult hemoglobin (HbA). More...
21 Mar 2019
Image: Bone marrow aspirate of a patient with paroxysmal nocturnal hemoglobinuria showing erythroid hyperplasia with occasional nuclear budding consistent with stressed erythropoiesis (Photo courtesy of Katherine Calco).

Significant Hemolysis Not Required for Thrombosis in PNH

Paroxysmal nocturnal hemoglobinuria (PNH), a rare hematological condition, presents with hemolytic or thrombotic symptoms. Cumulative thrombosis incidence in PNH over an eight to ten-year period is 23% to 30%, 20% of patients have multi-site thrombosis and 10% present with thrombosis. More...
19 Mar 2019
Image: Immunohistochemical stain for CD137 performed on paraffin-embedded tissue sections (cytoplasmic and membranous) using monoclonal BBK-2 clone (original magnification ×400) (Photo courtesy of Peter N. Carbone, MD and Qian-Yun Zhang, MD, PhD).

Immunohistochemical Stain Facilitates cHL Diagnosis

Remarkable efforts are underway to exploit classic Hodgkin lymphoma's (cHL) complex interplay of molecular alterations, loss of B-cell programming, and dependency of tumor microenvironment. More...
11 Mar 2019
Image: The QXDx BCR-ABL %IS kit and the QXDx AutoDG ddPCR system (Photo courtesy of Bio-Rad Laboratories).

Clinical ddPCR Diagnostic Test System Gets FDA Clearance

A test designed for monitoring treatment response in chronic myeloid leukemia and is also the first-ever digital polymerase chain reaction (PCR) product to receive US official government approval. More...
07 Mar 2019
Image: A blood smear of a patient with monoclonal B-cell lymphocytosis. The two atypical lymphocytes are mature with a small rim of basophilic cytoplasm and clumped or cracked chromatin (Photo courtesy of Elizabeth Courville, MD).

Circulating Plasma DNA Potentially Identifies Incipient Tumors

Early cancer diagnosis might improve survival rates. As circulating tumor DNA (ctDNA) carries cancer-specific modifications, it has great potential as a noninvasive biomarker for detection of incipient tumors. More...
06 Mar 2019
Image: The FACSCalibur flow cytometer used to immunophenotype pediatric leukemia (Photo courtesy of Becton Dickinson).

Peripheral Blood Flow Cytometry Classifies Pediatric Acute Leukemia

Historically, flow cytometry performed on the bone marrow aspirate (BMFC) has been the standard for the immunophenotypic characterization of acute leukemia. Recent data have demonstrated the high sensitivity and specificity of peripheral blood flow cytometry for the diagnosis of pediatric leukemia. More...
25 Feb 2019
Image: A diagram of how leukemia NOX2 derived superoxide is a driver of pro-tumoral p16INK4a-dependent senescence in bone marrow stromal cells (Photo courtesy of University of East Anglia).

Leukemia Prematurely Ages Bone Marrow Cells

Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cells. More...
20 Feb 2019
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The Hematology channel at LabMedica covers the all aspect of plasma, coagulation, transfusion medicine, and blood banking, as well as related lab tools and techniques.
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