We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App




Platelet Volume Related to Geriatric Patient In-Hospital Mortality

By LabMedica International staff writers
Posted on 28 Aug 2019
Print article
Image: The BC-5800 hematology autoanalyzer (Photo courtesy of Mindray).
Image: The BC-5800 hematology autoanalyzer (Photo courtesy of Mindray).
Treatment of acute coronary syndrome involves inhibition of platelet activity and thrombus formation. Platelets play a significant part during myocardial infarction by enhancing microvascular obstruction and secreting vasoactive peptides.

Platelet reactivity is an important matter, and there is evidence that larger platelet size, measured as mean platelet volume (MPV), is associated with enhanced platelet activity. Higher MPVs are observed in patients with acute coronary syndromes compared with patients with stable angina or normal coronary arteries. Elevated MPV is associated with myocardial infarction and death.

Medical Biochemists and Cardiologists at the Recep Tayyip Erdoğan University (Rize, Turkey) enrolled 194 consecutive ST segment elevation myocardial infarction (STEMI) patients in a retrospective observational study between December 2012 and May 2014. The study population was divided into two groups on the basis of admission MPVs. The 49 patients in the high-MPV group had an MPV in the third tertile (>0.89 fL), and the 145 patients in the low-MPV group had an MPV in the lower two tertiles (≤0.89 fL).

The team collected blood samples in standardized tubes containing dipotassium EDTA, and all measurements were performed by an optical laser method with a Mindray BC-5800 hematology analyzer. High-sensitivity troponin T was quantified with a cobas e 411 analyzer. A 12-lead electrocardiogram was recorded in each patient just after hospital admission, and the myocardial infarction type was obtained from the electrocardiogram.

The scientists reported that patients in the high-MPV group were older, more of them had three-vessel disease, and they had higher in-hospital mortality. Patients with in-hospital death were older, had higher Gensini score, creatinine concentration, and MPV, and had lower high-density lipoprotein (HDL) cholesterol concentration. MPV, age, HDL cholesterol concentration, creatinine concentration, and Gensini score were found to be independent predictors of in-hospital death.

The authors concluded that their results suggest that high admission MPV levels are associated with increased in-hospital mortality in geriatric patients with STEMI undergoing primary percutaneous coronary intervention (PCI). The study was published on July 1, 2019, in the journal Cardiovascular Innovations and Applications.

Related Links:
Recep Tayyip Erdoğan University

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
HLX
Complement 3 (C3) Test
GPP-100 C3 Kit
New
Gold Member
Fully Automated Cell Density/Viability Analyzer
BioProfile FAST CDV

Print article

Channels

Clinical Chemistry

view channel
Image: Reaching speeds up to 6,000 RPM, this centrifuge forms the basis for a new type of inexpensive, POC biomedical test (Photo courtesy of Duke University)

POC Biomedical Test Spins Water Droplet Using Sound Waves for Cancer Detection

Exosomes, tiny cellular bioparticles carrying a specific set of proteins, lipids, and genetic materials, play a crucial role in cell communication and hold promise for non-invasive diagnostics.... Read more

Molecular Diagnostics

view channel
Image: The study showed the blood-based cancer screening test detects 83% of people with colorectal cancer with specificity of 90% (Photo courtesy of Guardant Health)

Blood Test Shows 83% Accuracy for Detecting Colorectal Cancer

Colorectal cancer is the second biggest cause of cancer deaths among adults in the U.S., with forecasts suggesting 53,010 people might die from it in 2024. While fewer older adults are dying from this... Read more

Microbiology

view channel
Image: The new platform is designed to perform blood-based diagnoses of nontuberculosis mycobacteria (Photo courtesy of 123RF)

New Blood Test Cuts Diagnosis Time for Nontuberculous Mycobacteria Infections from Months to Hours

Breathing in nontuberculous mycobacteria (NTM) is a common experience for many people. These bacteria are present in water systems, soil, and dust all over the world and usually don't cause any problems.... Read more

Industry

view channel
Image: These new assays are being developed for use on the recently introduced DxI 9000 Immunoassay Analyzer (Photo courtesy of Beckman Coulter)

Beckman Coulter and Fujirebio Expand Partnership on Neurodegenerative Disease Diagnostics

Beckman Coulter Diagnostics (Brea, CA, USA) and Fujirebio Diagnostics (Tokyo, Japan) have expanded their partnership focused on the development, manufacturing and clinical adoption of neurodegenerative... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.