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BioResearch

Image: A photomicrograph of the skin showing dermal cells in blue and fat cells in green. The fat cell layer forms the final barrier against bacteria entering deep into the body (Photo courtesy of the University of California, San Diego).

Blocking Expression of TGF-Beta Preserves Healthy Skin

Researchers have identified the molecular mechanism that gives the skin of infants and children that plump, youthful look while producing a peptide that plays a critical role in fighting infections. More...
10 Jan 2019
Image: Proteins designed in the lab can now zip together in much the same way that DNA molecules zip up to form a double helix. The technique could enable the design of protein nanomachines that can potentially help diagnose and treat disease, allow for the more exact engineering of cells, and perform a wide variety of other tasks (Photo courtesy of the Institute for Protein Design, University of Washington).

Computer-Based Strategy Designed for Protein Nanomachines

A team of bio-molecular engineers used the Rosetta software suite to design orthogonal protein heterodimers, which are protein "nanomachines" that are expected to enable sophisticated protein-based control logic for synthetic biology applications. More...
09 Jan 2019
Image: New research marks a crucial step forward in the effort to identify the cause of impaired vision in people around the world. Eyesight problems frequently have a genetic origin, and often a mutation in just a single gene is involved. However, the genetic contribution of many eye-related issues remains poorly understood (Photo courtesy of the IMPC).

Ocular Disease Genes Identified by Screening Multiple Genomes

Results obtained during the genetic screening of a large number of mice revealed 347 genes that influenced ocular phenotypes, 75% of which were not previously known to be linked to ocular disease. More...
08 Jan 2019
Image: Growth of the newly discovered Streptomyces sp. myrophorea, so named because it produces a distinctive fragrance similar to that of oil of wintergreen. Although superficially resembling fungi, Streptomyces are true bacteria and are the source of two-thirds of the various frontline antibiotics used in medicine (Photo courtesy of G. Quinn, Swansea University).

Bacteria from Medicinal Soil Kills Antibiotic-Resistant Pathogens

A novel strain of Streptomyces bacteria isolated from an Irish bog with soil having a long tradition of use in folk medicine was shown to possess potent anti-microbial properties especially against antibiotic resistant pathogens. More...
07 Jan 2019
Image: A diagram of the process by which a fluorescent-labeled stem cell line was generated for production of cardiac cells (Photo courtesy of Pennsylvania State University).

Tracer Cardiomyocytes Generated by Stem Cell Modification

The CRISPR/Cas9 genome-editing tool was used as part of a process designed to produce fluorescent-labeled cardiomyocytes (CMs) from human pluripotent stem cells (hPSCs). More...
03 Jan 2019
Image: A digitally colorized transmission electron microscopic (TEM) image of Zika virus. Virus particles, colored blue, are 40 nanometers in diameter, with an outer envelope and an inner dense core (Photo courtesy of the CDC).

Zika Vaccine Protects without Inducing Antibody Production

A novel vaccine against Zika virus infection, which was successfully tested in mouse models, is based on the delivery of genes for Zika virus structural proteins via attenuated adenovirus vectors. More...
02 Jan 2019
Image: The Nadia automated single cell Drop-seq RNA sequencing system (Photo courtesy of Dolomite Bio).

RNA Sequencing Offers Greater Capacity for Recovery and Analysis of Molecules

A recent paper described a significant modification that enables Drop-seq single-cell RNA sequencing technology to recover and analyze a more diverse variety of molecules. More...
01 Jan 2019
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BioResearch brings the latest research news on the genome, proteome, metabolome, on drug discovery, and therapeutics. Biotech researchers, lab administrators, technologists, drug manufacturers, and suppliers can find the latest research news and information related to their fields of endeavor here.
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