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改进型肺结核血检产品发布

By LabMedica International staff writers
Posted on 06 Dec 2017
肺结核(TB)是一种细菌感染,主要通过活跃肺结核患者的咳嗽传播。据估计,2015年全世界有1040万活跃肺结核的新病例,肺结核导致180万例死亡。

有潜伏肺结核感染(LTBI)时,人感染了细菌却没产生症状,除非后来发展成活跃疾病。全球范围内,估计每三人中就有一人有潜伏肺结核感染,其中约5%-10%的人如果不接受治疗将在某个时候发展成活跃肺结核。

筛查高风险人群和治疗LTBI在美国和许多欧洲国家以及世界上其它发达国家和新兴市场控制肺结核的行动中发挥着重要作用。第四代肺结核血液检验试剂盒已经发布,并于2017年10月9日在美国上市。新颖的CD4/CD8设计能够最全面地评估病人对肺结核感染的免疫应答。

德国希尔登凯杰公司的QuantiFERON-TB Gold Plus (QFT-Plus)采用创新性抗原测量CD4+和CD8+ T细胞介导的对肺结核感染的免疫应答,推动了肺结核检验技术的进步,能更全面地评估肺结核感染。研究显示CD8+ T细胞对于结核分枝杆菌的免疫起着重要作用。已发表的证据凸显了CD8+ T细胞将来区分活跃肺结核与潜伏肺结核、区分最近病毒与以前感染、检测共感染人类免疫缺陷病毒(HIV)的人群以及幼儿体内的肺结核以及评估人对肺结核治疗的反应的潜力。其它检验没有针对CD4和CD8 T细胞应答做优化。

凯杰公司肺结核医疗与科研事业部高级主管Masae Kawamura大夫说:“QFT-Plus的CD4+/CD8+ T细胞专利技术有望提供有关高风险患者的重要信息,如哪些人接触过活跃肺结核患者或HIV阳性者,同时维持高特异性。在美国,检验准确度从未如此重要,因为该国重拳出击,利用政策推行定向检验和预防性治疗,以遏止肺结核。目前估计美国93%的肺结核病来自1300万潜伏肺结核感染者。”

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