We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us

Download Mobile App




Revolutionary Multi-Cancer Early Detection Test Offers Affordable Screening Tool for LMICs

By LabMedica International staff writers
Posted on 20 Jun 2023

Cancer claimed almost 10 million lives globally last year, with a majority of the cases detected too late for effective treatment. More...

While early screening tests for cancer can save lives, these clinically validated tests only cover a few types, such as lung, colon, liver, breast, cervix, and prostate cancers, and their detection rates and specificity are limited. Conventional cancer screening technologies often prove unsuitable for low- and middle-income countries (LMICs) due to their cost, complexity, and reliance on substantial medical infrastructure. Now, a ground-breaking multi-cancer early detection (MCED) test, driven by artificial intelligence (AI) technology, could potentially save numerous lives by identifying cancer at earlier stages. The MCED test could revolutionize early cancer detection in LMICs.

OncoSeek developed by SeekIn Inc. (Shenzhen, China) is an MCED test based on the analysis of protein tumor markers (PTMs). It can simultaneously detect characteristic tumor markers for different types of cancers. Utilizing AI, the test can differentiate between individuals with cancer and those without by calculating a probability of cancer (POC) index. This calculation is based on the plasma levels of seven PTMs, as well as the gender and age of the subjects. With only a blood draw required at screening sites, OncoSeek is both affordable and accessible, making it a sustainable option in LMICs.

A recent study showed that OncoSeek considerably reduces the rate of false positives compared to traditional clinical methods. The study involved nearly 10,000 participants from China and the United States, consisting of 1,959 cancer patients and 7,423 healthy individuals. Each participant had one tube of peripheral blood collected for the detection of seven specific proteins using a standard clinical electrochemiluminescence immunoassay analyzer. After PTMs were quantified, OncoSeek, using AI, distinguished cancer patients from non-cancer individuals, calculated the POC index and predicted the possible affected tissue of origin (TOO) for those with detected cancer signals in blood.

The test demonstrated a sensitivity of 51.7%, and a specificity of 92.9%, resulting in an overall accuracy of 84.3%, with a sensitivity of 49.5% in stage I and II patients. For the detection of nine common cancer types, which account for approximately 59.2% of annual global cancer deaths, sensitivities ranged from 37.1% to 77.6%. The overall accuracy of TOO prediction in true positives is 66.8%, which could be a helpful tool in clinical diagnostic workups. OncoSeek, offering a non-invasive, efficient, and cost-effective solution for MCED, received CE-IVD Mark approval in September 2022.

Related Links:
SeekIn Inc. 


Gold Member
Antipsychotic TDM Assays
Saladax Antipsychotic Assays
3-Part Differential Hematology Analyzer
Swelab Alfa Plus Sampler
New
Autoimmune Disease Diagnostic
Chorus ds-DNA-G
New
Automated Chemiluminescence Immunoassay Analyzer
MS-i3080
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Hematology

view channel
Image: The microfluidic device for passive separation of platelet-rich plasma from whole blood (Photo courtesy of University of the Basque Country)

Portable and Disposable Device Obtains Platelet-Rich Plasma Without Complex Equipment

Platelet-rich plasma (PRP) plays a crucial role in regenerative medicine due to its ability to accelerate healing and repair tissue. However, obtaining PRP traditionally requires expensive centrifugation... Read more

Immunology

view channel
Image: PD-1 protein blockade is the standard treatment for advanced melanoma among the different types of immunotherapy (Photo courtesy of 123RF)

Precision Tool Predicts Immunotherapy Treatment Failure in Melanoma Patients

Melanoma, though accounting for only about 4% of skin tumors, is the deadliest form of skin cancer due to its high potential to metastasize. While immunotherapy, especially PD-1 protein blockade, has revolutionized... Read more

Pathology

view channel
Image: Researchers have developed a novel method to analyze tumor growth rates (Photo courtesy of Adobe Stock)

Novel Method To Analyze Tumor Growth Rates Helps Tracks Progression Between Diagnosis and Surgery

Patients diagnosed with breast cancer often worry about how quickly their tumors grow while they wait for surgery, and whether delays in treatment might allow the disease to spread beyond the point of cure.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.