We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Technopath Clinical Diagnostics - An LGC Company

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
06 Feb 2023 - 09 Feb 2023

Genetic Test Improves Ovarian Cancer Treatment

By LabMedica International staff writers
Posted on 12 Jan 2023
Print article
Image: The new genetic test helps to identify ovarian cancer patients who benefit from a new drug (Photo courtesy of Helsinki University Hospital)
Image: The new genetic test helps to identify ovarian cancer patients who benefit from a new drug (Photo courtesy of Helsinki University Hospital)

Ovarian cancer has the worst prognosis among all gynecological cancers due to delay in diagnosis as its symptoms are often minor and unclear. Of late, the new PARP inhibitors as maintenance treatment for ovarian cancer after surgery and cytostatic therapy in newly-diagnosed ovarian cancer have demonstrated excellent results. However, the therapy can also cause serious side-effects, making it vital to target it to only those patients who stand to benefit the most from the treatment. Now, a new genetic test can identify ovarian cancer patients who can benefit from PARP inhibitors.

The genetic test developed at the University of Helsinki (Helsinki, Finland) and Helsinki University Hospital (Helsinki, Finland) using machine learning can identify patients whose tumors carry certain gene defects that are typical of ovarian cancer. The lesions are caused by a deficiency in the homologous recombination DNA repair pathway (HRD). These tumor types are the ones that are sensitive to PARP inhibitors. Their study has shown that each cancer type is associated with different characteristics of the genetic lesions related to HRD. In fact, it was important to develop a test optimized for ovarian cancer in order to advance the precision of therapies for the cancer type.

“The genetic test helps to identify patients who do not benefit from the drug, thus avoiding unnecessary treatment and the adverse effects associated with the drug,” said Specialist Anniina Färkkilä from HUS Helsinki University Hospital. “This therapy can now be administered to as many as half of the patients with ovarian cancer.”

“Clinical trials have shown that patients with HRD tumors have a strong response to PARP inhibitors, while the response of other patients is poor,” added Doctoral Researcher Fernando Perez Villatoro from the University of Helsinki. “The gene test and the algorithms are now freely available, and can be used in clinical care and trials to guide the treatment of ovarian cancer.”

Related Links:
University of Helsinki 
Helsinki University Hospital 

Gold Supplier
Rheumatoid Factors (RF) Test
Rheumatoid Factors (RF)
New
HbA1c Test
LumiraDx HbA1c Test
New
Silver Supplier
Four-Channel Laboratory Alarm Timer
Laboratory Timer
New
Rapid H. Pylori Antibody Test
Reveal HP

Print article
MEDLAB - INFORMA

Channels

Immunology

view channel
Image: Histopathology of Langerhans cell histiocytosis: The variation in nuclear contours of these cells is evident in this lesion. Classic `kidney bean` nuclei of Langerhans cells with a central groove are present (Photo courtesy of John Lazarchick, MD)

Cooperativity Between Myeloid Lineages Promotes Langerhans Cell Histiocytosis Pathology

Langerhans cell histiocytosis (LCH) is an inflammatory myeloid neoplasia seen in children and adults who present with lesions composed of pathologic variants of myeloid cells that share certain phenotypic... Read more

Microbiology

view channel
Image: Medical illustration of Carbapenem-resistant Enterobacteriacea (Photo courtesy of CDC, Stephanie Rossow)

Breakthrough Test Enables Targeted Antibiotic Therapy for Various Enterobacter Species

Bacteria of the Enterobacter genus are considered to be the most dangerous bacteria linked to hospital infections across the world. Some of their representatives demonstrate high resistance to commonly-used... Read more

Technology

view channel
Image: Flexible copper sensor made cheaply from ordinary materials (Photo courtesy of University of São Paulo)

Low-Cost Portable Sensor Detects Heavy Metals in Sweat

Heavy metals like lead and cadmium can be found in batteries, cosmetics, food and many other things that have become a part of daily life. However, they become toxic if they accumulate in the human body... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.