We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
PURITAN MEDICAL

Download Mobile App




Events

15 Apr 2024 - 17 Apr 2024
23 Apr 2024 - 26 Apr 2024
25 Apr 2024 - 27 Apr 2024

Groundbreaking POCT Device Detects UTI Causing Bacteria in Five Minutes

By LabMedica International staff writers
Posted on 17 Aug 2023
Print article
Image: A point-of-care aptasensor enables rapid diagnosis of UTIs (Photo courtesy of ACS Central Science, 2023)
Image: A point-of-care aptasensor enables rapid diagnosis of UTIs (Photo courtesy of ACS Central Science, 2023)

Urinary tract infection (UTI) is a prevalent health concern globally, particularly affecting women during pregnancy. Various bacteria can cause UTIs, leading to symptoms like a burning sensation during urination and an increased need to urinate. If the infection spreads to the kidneys, it can result in serious complications. Conventionally, urine cultures are used to detect and identify the specific bacteria responsible, a process that takes at least two days. This delay can cause suffering for the patient and even be fatal in some instances. In rural areas, the problem is exacerbated by inadequate infrastructure, high testing costs, and extended testing time, leading to many UTIs going undetected.

Researchers at the Indian Institute of Technology Guwahati (IIT Guwahati, Assam, India) have made a significant breakthrough by creating a 3D printed photodetector device that can identify and quantify a UTI-causing bacteria known as Klebsiella pneumoniae within five minutes from a urine sample. This capability is highly significant, as Klebsiella pneumoniae is not only a common cause of UTI but is also linked to pneumonia and soft tissue infections.

To create the prototype, the researchers utilized gold nanoparticles combined with specially engineered aptamers. An aptamer is similar to a 3D puzzle piece that fits only on the surface of specific bacteria. As a result, the gold nanoparticles get agglomerated on the surface of the target bacteria, generating a unique signature detectable by a UV-visible spectrophotometer. The device’s biosensor identifies changes in light intensity when the aptamer-gold nanoparticles-bacteria come together. The aptamer and bacteria combine instantly to result in rapid detection. Importantly, this innovative prototype is not only specific to Klebsiella pneumoniae but is also adaptable to different types of bacteria, offering great potential for primary healthcare. Furthermore, the cost-effective nature of the device could make it particularly beneficial in rural areas where UTIs frequently remain undiagnosed due to limited access to testing facilities.

Related Links:
IIT Guwahati 

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Magnetic Bead Separation Modules
MAG and HEATMAG
Complement 3 (C3) Test
GPP-100 C3 Kit
Gold Member
Xylazine Immunoassay Test
Xylazine ELISA

Print article

Channels

Clinical Chemistry

view channel
Image: The 3D printed miniature ionizer is a key component of a mass spectrometer (Photo courtesy of MIT)

3D Printed Point-Of-Care Mass Spectrometer Outperforms State-Of-The-Art Models

Mass spectrometry is a precise technique for identifying the chemical components of a sample and has significant potential for monitoring chronic illness health states, such as measuring hormone levels... Read more

Molecular Diagnostics

view channel
Image: AI analysis of DNA fragmentomes and protein biomarkers noninvasively detects ovarian cancer (Photo courtesy of Adobe Stock)

Blood-Based Machine Learning Assay Noninvasively Detects Ovarian Cancer

Ovarian cancer is one of the most common causes of cancer deaths among women and has a five-year survival rate of around 50%. The disease is particularly lethal because it often doesn't cause symptoms... Read more

Hematology

view channel
Image: The CAPILLARYS 3 DBS devices have received U.S. FDA 510(k) clearance (Photo courtesy of Sebia)

Next Generation Instrument Screens for Hemoglobin Disorders in Newborns

Hemoglobinopathies, the most widespread inherited conditions globally, affect about 7% of the population as carriers, with 2.7% of newborns being born with these conditions. The spectrum of clinical manifestations... Read more

Immunology

view channel
Image: The groundbreaking treatment approach has shown promise in hard-to-treat cancers (Photo courtesy of 123RF)

Genetic Testing Combined With Personalized Drug Screening On Tumor Samples to Revolutionize Cancer Treatment

Cancer treatment typically adheres to a standard of care—established, statistically validated regimens that are effective for the majority of patients. However, the disease’s inherent variability means... Read more

Pathology

view channel
Image: ‘Virtual biopsy’ allows clinicians to analyze skin noninvasively (Photo courtesy of Stanford Medicine)

Virtual Skin Biopsy Determines Presence of Cancerous Cells

When dermatologists spot an unusual mark on a patient's skin, they face a choice: monitor it for some time or remove it for biopsy. Similarly, when removing breast tumors, surgeons must send excised tissues... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.