We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
LGC Clinical Diagnostics

Download Mobile App


24 Feb 2024 - 28 Feb 2024
05 Mar 2024 - 07 Mar 2024

Fluorescent Carbon Nanotubes Accurately Detect Bacteria and Viruses

By LabMedica International staff writers
Posted on 31 Jul 2023
Print article
Image: 3D printed model of a carbon nanotube (Photo courtesy of RUB)
Image: 3D printed model of a carbon nanotube (Photo courtesy of RUB)

An interdisciplinary research team that comprised scientists from Ruhr University Bochum (RUB, Bochum, Germany) has developed an innovative method to construct modular optical sensors capable of identifying viruses and bacteria. The team utilized fluorescent carbon nanotubes attached to a novel type of DNA anchors which serve as molecular handles. These anchor structures can be utilized to conjugate biological recognition units such as antibodies aptamers to the nanotubes, enabling interaction with bacterial or viral molecules. This interaction impacts the fluorescence of the nanotubes, causing their brightness levels to increase or decrease.

The research team utilized tubular nanosensors composed of carbon, each with a diameter of less than one nanometer. When irradiated with visible light, these nanotubes emit near-infrared light, a spectrum invisible to the human eye but ideal for optical applications due to the significant reduction of other signals within this range. Previously, the team had successfully manipulated the nanotubes' fluorescence to detect vital biomolecules. Their latest effort involved customizing carbon sensors for easy detection of various target molecules.

This breakthrough was achieved with the help of DNA structures with guanine quantum defects. This process involved linking DNA bases to the nanotube in order to introduce a defect into the nanotube's crystal structure. Consequently, the nanotubes' fluorescence underwent a quantum-level change. In addition, the defect functioned as a molecular handle, enabling the addition of a detection unit that could be adjusted to the respective target molecule to identify a specific viral or bacterial protein.

The team demonstrated the new sensor concept by targeting the SARS-CoV-2 spike protein. Researchers used aptamers that bind to the SARS-CoV-2 spike protein, following which the fluorescent sensors reliably indicated the protein's presence. Notably, the selectivity and stability of sensors featuring guanine quantum defects surpassed those of sensors without such defects, especially when in solution.

Related Links:
Ruhr University Bochum

Platinum Member
COVID-19 Rapid Test
OSOM COVID-19 Antigen Rapid Test
Anti-Cyclic Citrullinated Peptide Test
GPP-100 Anti-CCP Kit
Gold Member
Real-time PCR System
GentierX3 Series

Print article


Clinical Chemistry

view channel
Image: Wireless Point-of-Care Testing for Hepatitis B Virus (Photo courtesy of Chulalongkorn University)

Wireless Hepatitis B Test Kit Completes Screening and Data Collection in One Step

Hepatitis B, a significant global health concern, is responsible for chronic liver diseases like cirrhosis and liver cancer which is one of the most common cancers worldwide. The challenge with hepatitis... Read more


view channel
Image: The Gazelle Hb Variant Test (Photo courtesy of Hemex Health)

First Affordable and Rapid Test for Beta Thalassemia Demonstrates 99% Diagnostic Accuracy

Hemoglobin disorders rank as some of the most prevalent monogenic diseases globally. Among various hemoglobin disorders, beta thalassemia, a hereditary blood disorder, affects about 1.5% of the world's... Read more


view channel
Image: The photoacoustic spectral response sensing instrument is based on low-cost laser diodes (Photo courtesy of Khan et al., doi 10.1117/1.JBO.29.1.017002)

Compact Photoacoustic Sensing Instrument Enhances Biomedical Tissue Diagnosis

The pursuit of precise and efficient diagnostic methods is a top priority in the constantly evolving field of biomedical sciences. A promising development in this area is the photoacoustic (PA) technique.... Read more


view channel
Image: The companies will develop genetic testing systems based on capillary electrophoresis sequencers (Photo courtesy of 123RF)

Sysmex and Hitachi Collaborate on Development of New Genetic Testing Systems

Sysmex Corporation (Kobe, Japan) and Hitachi High-Tech Corporation (Tokyo, Japan) have entered into a collaboration for the development of genetic testing systems using capillary electrophoresis sequencers... Read more
Copyright © 2000-2024 Globetech Media. All rights reserved.