We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
GLOBETECH PUBLISHING LLC

Weezion

Weezion SAS develops and promotes rapid and economic solutions for In-vitro Diagnosis (IVD) of bacteremia or fungemia... read more Featured Products: More products

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

Diagnostic Solution Identifies Sepsis Causing Microorganisms and Predicts Antibiotic Resistance in 90 Minutes

By LabMedica International staff writers
Posted on 06 Jun 2022
Print article
Image: The Weezion dx solution is designed for medical analysis hospital platforms that diagnose bacteremia (Photo courtesy of Weezion)
Image: The Weezion dx solution is designed for medical analysis hospital platforms that diagnose bacteremia (Photo courtesy of Weezion)

Sepsis is a life-threatening organ dysfunction caused by the body’s toxic response to infection and can progress to septic shock, which has a mortality rate of 40%. A blood culture is the main way to check for the microbial agent (bacteria or fungi) causing the infection and will allow to diagnose the bacteremia or fungemia as well as determine the sensitivity of these microorganisms to antibiotics and antifungals. The speed at which appropriate treatment can be administered, based on the type of infection, determines the survival of the patient. Now, a new in-vitro diagnostic solution for microbial infections identifies the pathogen(s) as well as allows to identify and predict the resistance profile within 90 minutes to ensure that the appropriate anti-infective treatment can be adapted or administered quickly, reducing the risk of death in severe systemic infections.

Weezion’s (Lyon, France) Weezion dx solution is based on a proteomic approach using patented targeted mass spectrometry technology and identifies the pathogen(s) present in the clinical sample, as well as jointly detects and quantifies the proteins responsible for antibiotic resistance. Using a positive blood culture, the solution allows clinicians to identify and predict the resistance profile within 90 minutes.

Despite major advances in the last 20 years in understanding the pathophysiology of sepsis, no therapeutic revolution has yet seen the light of day. It is therefore in the diagnostic phase where progress can be made. Reducing the time to receive the results of the identification of the pathogen and its resistance profile will ensure a more rapid implementation or adaptation of a suitable anti-infective treatment. Existing identification methods, based on the molecular detection of the main pathogens and some of their resistance genes, are expensive and non-exhaustive. MALDI/TOF mass spectrometry technology has shortened the identification phase but does not provide any prediction of resistance. The rapid antibiogram from a positive blood culture vial takes several hours of incubation before validation and most of the technologies used are expensive. Therefore there is an urgent need for a resistance identification and determination tool that is rapid, more comprehensive than current methods and economically sustainable.

Designed for medical analysis hospital platforms that diagnose bacteremia, the Weezion dx solution is comprised of an operational pre-analytical sample protocol from a blood culture aliquot that requires limited manual or automated steps, in less than 10 minutes. It follows a global analytical protocol that guarantees a 90-minute diagnostic phase and allows the management of three blood culture samples per hour in order to satisfy the maximum flow of large hospital microbiology platforms. It includes prototype software to manage the decision tree of the mass spectrometry and enables identification of a panel of scout ribosomal peptides specific to microbial families or species that allows for the implementation of a decision tree to ensure accurate identification of 98% of pathogens associated with bacteremia. The Weezion dx solution also enables the identification of a panel of peptides that detects the resistance mechanisms to the three main types of antibiotics used to treat bacteremia.

Related Links:
Weezion 

New
Gold Supplier
Real-Time Diagnostics Onscreen Viewer
GEMweb Live
New
1,5-AG Test
1,5-Anhydroglucitol Test Kit
New
Influenza A+B Test
Anyplex FluA/B Typing Real-Time Detection
New
Cytomegalovirus ELISA Test
Captia Cytomegalovirus (CMV) IgM EIA

Print article
IIR Middle East

Channels

Technology

view channel
Image: OneDraw Blood Collection Device significantly reduces obstacles for drawing blood (Photo courtesy of Drawbridge Health)

Near Pain-Free Blood Collection Technology Enables High-Quality Testing

Blood tests help doctors diagnose diseases and conditions such as cancer, diabetes, anemia, and coronary heart disease, as well as evaluate organ functionality. They can also be used to identify disease... Read more

Industry

view channel
Image: The global infectious disease IVD market is expected to hit USD 57 billion by 2030 (Photo courtesy of Pexels)

Global Infectious Disease IVD Market Dominated by Molecular Diagnostics Technology

The global infectious disease in vitro diagnostics (IVD) market stood at USD 113.7 billion in 2021 and is expected to grow at a CAGR of -7.41% from 2022 to 2030 to hit around USD 56.89 billion by 2030,... Read more
Copyright © 2000-2022 Globetech Media. All rights reserved.