We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us

Download Mobile App


ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
06 Feb 2023 - 09 Feb 2023

Laboratory Features of Trichinellosis and Eosinophilia Threshold Determined

By LabMedica International staff writers
Posted on 01 Dec 2022
Print article
Image: Trichinella sp. found in muscle tissue (Photo courtesy of McGill University)
Image: Trichinella sp. found in muscle tissue (Photo courtesy of McGill University)

Trichinella nativa is a nematode worm, one of the species of the genus Trichinella, found in arctic and subarctic regions. It is highly pathogenic and has a high resistance to freezing. It is encapsulated, and infects a wide variety of mammals and birds.

T. nativa is a species commonly found in omnivores and carnivores such as wild boars, foxes, raccoon dogs and bears. In the Arctic, the corpses of animals that die may get frozen and later be consumed by scavengers. This worm remains viable even after being frozen at −18 °C for four years. Eosinophilia is a well-characterized feature of infection that is readily available for most cases.

Infectious Disease Scientists at the McGill University Health Centre (Montreal, QC, Canada) and their colleagues reviewed all requests for Trichinella serologic testing sent from Quebec to the National Reference Centre for Parasitology (Toronto, ON, Canada). They identified 43 cases of trichinellosis and a set of 31 region-matched controls. Information on signs and symptoms was available for only 19/43 case-patients, but demographic, laboratory, and clinical outcomes were well documented. Case-patients had a median age of 40 years and were mostly female (30/43, 69.8%).

Laboratory information was available for 41/43 case-patients. Features of Trichinella infection presumptively caused by T. nativa, are similar to those reported for T. spiralis infection, including elevated creatinine kinase and eosinophilia. The variable that differed most between cases and controls was peak absolute eosinophilia (5.35 versus 0.80 × 109 cells/L). Using ROC analysis, they identified an absolute eosinophilia threshold of >0.8 × 109 cells/L, which identified all cases in this series with a specificity of 71%.

The authors noted that automated flags and reflex testing in the local laboratory has now incorporated the threshold identified in their analysis. In the absence of a defined alternative diagnosis, eosinophil counts of >0.80 ×109 cells/L should prompt clinical consideration of trichinellosis and further investigation. The study was published in the November 2022 edition of the journal Emerging Infectious Diseases.

Related Links:
McGill University Health Centre
National Reference Centre for Parasitology 

Gold Supplier
Clinical Centrifuge
BenchMate C6V
Silver Supplier
Laboratory Software
FlowLab Software
Electronic Pipette

Print article


Molecular Diagnostics

view channel
Image: The new blood test measures stress hormone levels after heart attacks (Photo courtesy of University of Oxford)

New Blood Test Could Ensure Timely Life-Saving Treatment of Heart Attack Victims

Cardiovascular disease, one of the leading causes of death, generally manifests itself through heart attacks. Most patients with very large heart attacks are treated using an emergency procedure called... Read more


view channel
Image: Scientists have won USD 9.5 million to study emerging pathogens (Photo courtesy of Pexels)

Study of Emerging Pathogens to Better Understand Influenza-Antibody Interactions Could Improve Diagnostics

Outbreaks of Avian influenza have occurred around the world for over a century. The highly pathogenic H5N1 virus which was first identified in 1996 can lead to severe disease and has a high fatality rate... Read more


view channel
Image: Flexible copper sensor made cheaply from ordinary materials (Photo courtesy of University of São Paulo)

Low-Cost Portable Sensor Detects Heavy Metals in Sweat

Heavy metals like lead and cadmium can be found in batteries, cosmetics, food and many other things that have become a part of daily life. However, they become toxic if they accumulate in the human body... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.