We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
PURITAN MEDICAL

Siemens Healthineers

Provides customized electronic systems and advanced imaging, diagnostics, therapy, and healthcare IT solutions for th... read more Featured Products: More products

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.

First and Only Fully Automated Assay of Its Kind Advances Diagnostics for Bleeding Disorder

By LabMedica International staff writers
Posted on 07 Oct 2022
Print article
Image: The INNOVANCE VWF Ac assay is a turbidimetric, latex-based assay that employs a liquid, ready-to-use reagent (Photo courtesy of Siemens)
Image: The INNOVANCE VWF Ac assay is a turbidimetric, latex-based assay that employs a liquid, ready-to-use reagent (Photo courtesy of Siemens)

Von Willebrand disease (VWD) is the most common inherited bleeding disorder, affecting approximately one percent of the population - and both men and women equally. Physicians diagnose VWD based on bleeding symptoms, patient history, and lab test results, including von Willebrand factor (VWF) activity. Until now, VWF activity assays were disadvantaged with low precision and sensitivity, and with difficulties in diagnosing certain VWF polymorphisms. To help address these deficiencies, the International Society on Thrombosis and Hemostasis (ISTH) recently published a guideline changing its recommendation for VWF activity assays from the ristocetin cofactor assay (VWF:RCo) to newer assays (VWF:GPIbM) that directly measure the platelet binding activity of VWF without the need of ristocetin. Now, Siemens Healthineers (Erlangen, Germany) has announced that its INNOVANCE VWF Ac assay - the sole fully automated assay of its kind (VWF:GPIbM) - is now available to U.S. laboratories for use on the company’s BCS XP System, as well as on the Sysmex CS-2500 and CS-5100 hemostasis analyzers.

Siemens’ INNOVANCE VWF Ac assay is the only fully automated, commercially available VWF activity assay for laboratories in the U.S. that uses the guideline recommended VWF:GPIbM technology. The INNOVANCE VWF Ac assay is a liquid, ready-to-use assay, and offers laboratorians a broad measuring range with a lower limit of quantitation compared to the VWF:RCo technology. Currently deployed in many European laboratories, the assay's VWF:GPIbM technology allows for a more accurate functional assessment of VWF activity with greater precision and heightened sensitivity, and the ability to detect VWF variants that otherwise might be missed compared to other commercially available VWF assay technologies.

“After the positive experience we had using this assay in a study, we as caregivers in the U.S. are urgently waiting to use the INNOVANCE VWF Ac assay to diagnose our patients, as we believe it supports improved von Willebrand disease diagnosis and patient management - particularly now given the new recommendations from the ASH ISTH NHF WFH 2021 guidelines on the diagnosis of VWD,” said Dr. Steven Pipe, Professor of Pediatrics and Pathology from the University of Michigan, Ann Arbor.

Related Links:
Siemens Healthineers 

Gold Supplier
Automatic Western Blot Analyzer
Tenfly Phoenix Blot Analyzer
New
Silver Supplier
Auto Molecular Diagnostic System
ELITe InGenius
New
Thrombosis Viscoelasic Analysis System
ImproClot
New
3-in-1 Mixer
MixMate

Print article

Channels

Clinical Chem.

view channel
Image: Brief schematic diagram of the detection principle and method (Photo courtesy of CAS)

Rapid, Non-Invasive Method Diagnoses Type 2 Diabetes by Sniffing Urinary Acetone

Over 90% of diabetes cases are attributed to Type 2 diabetes (T2D), a prevalent metabolic condition that is expected to impact 380 million individuals globally by 2025. Despite being highly accurate, the... Read more

Molecular Diagnostics

view channel
Image: Researchers have identified the origin of subset of autoantibodies that worsen lupus (Photo courtesy of Pexels)

Lupus Biomarker Testing Could Help Identify Patients That Need Early and Aggressive Treatment

Systemic lupus erythematosus (SLE) is an autoimmune disease that occurs when the body's antibodies, which usually protect against infections, attack healthy cells and proteins. These autoantibodies can... Read more

Immunology

view channel
Image: A genetic test could guide the use of cancer chemotherapy (Photo courtesy of Pexels)

Genetic Test Predicts Whether Bowel Cancer Patients Can Benefit From Chemotherapy

Late-stage bowel cancer patients usually undergo a series of chemotherapies and targeted medicines for cancer treatment. However, the responses to the last-line chemotherapy treatment trifluridine/tipiracil... Read more

Microbiology

view channel
Image: Use of DBS samples can break barriers in hepatitis C diagnosis and treatment for populations at risk (Photo courtesy of Pexels)

DBS-Based Assay Effective in Hepatitis C Diagnosis and Treatment for At Risk Populations

In a bid to eliminate viral hepatitis as a public health threat by 2030, the World Health Organization (WHO) has put forth a proposed strategy. To this end, researchers at the Germans Trias i Pujol Research... Read more

Pathology

view channel
Image: New research has opened a path for fast and accurate cancer diagnosis (Photo courtesy of Imagene)

AI-Based Image Analysis Software Profiles Cancer Biomarkers in Real Time

Lung cancer is the most widespread type of cancer worldwide, resulting in approximately 1.76 million fatalities annually. Non-small cell lung cancer (NSCLC) accounts for 85% of all lung cancer diagnoses... Read more

Technology

view channel
Image: Live view of non-fluorescent specimens using the glowscope frame (Photo courtesy of Winona State University)

Device Converts Smartphone into Fluorescence Microscope for Just USD 50

Fluorescence microscopes are utilized to examine specimens labeled with fluorescent stains or expressing fluorescent proteins, like those tagged with green fluorescent protein. However, since these microscopes... Read more

Industry

view channel
Image: The global antimicrobial resistance diagnostics market size is expected to reach USD 5.7 billion by 2028 (Photo courtesy of Pexels)

Global Antimicrobial Resistance Diagnostics Market Driven by Increasing Hospital-Acquired Infections

Antimicrobial drugs are intended to counteract the harmful effects of microbes and promote a healthy life. However, their excessive use can result in the development of resistance, commonly referred to... Read more
Copyright © 2000-2023 Globetech Media. All rights reserved.