Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us

Download Mobile App




New Diagnosed Anemia Linked to Crohn’s Disease Risk

By LabMedica International staff writers
Posted on 28 Sep 2020
Inflammatory bowel disease (IBD) includes Crohn’s disease (CD) and ulcerative colitis (UC). More...
IBD is a chronic inflammatory gastrointestinal disorder that involves complex interactions among genetic, environmental, immunological, and microbiological factors.

Anemia can be caused by a variety of etiologies such as iron deficiency, chronic diseases, vitamin B12 or folate deficiency, and genetic factors. Anemia is a known risk factor for cardiovascular diseases, dementia, and chronic medical illness, leading to an increase in all-cause mortality.

Medical scientists from the Seoul National University College of Medicine (Seoul, South Korea) conducted a population-based study from a database for patients during 2009, during which time 9,962,064 individuals older than 20 years, who participated in the national health screening program. Anemia was defined as a hemoglobin level less than 13 g/dL in men and less than 12 g/dL in women. The investigators compared the rate of newly diagnosed IBD in anemic and non-anemic patients.

The team reported that during the mean follow-up period of 7.3 years, the incidences of CD and UC in anemic patients were 2.89 and 6.88 per 100,000 person-years, respectively. The risk of CD was significantly higher in anemic patients than in non-anemic individuals [adjusted hazard ratio (aHR), 2.084; 95% confidence interval (CI), 1.769–2.455]. The risk of CD development was inversely proportional to the hemoglobin concentration. A J-curve relationship was observed between age and the risk of CD in anemic patients. The risk of CD in male anemic patients was significantly higher than that in female anemic patients (aHR, 1.432 versus 1.240, respectively). By contrast, there was no statistically significant difference in the risk of developing UC in anemic and non-anemic individuals (aHR, 0.972; 95% CI, 0.880–1.073).

The risk of CD development was correlated with the severity of anemia as determined by the hemoglobin level. When patients were stratified with respect to hemoglobin levels, the risk of CD was 3.3 times higher in the lowest 10% group than in the highest 10% group. Jong Pil Im, MD, PhD, a professor of Internal Medicine and a senior author of the study, said, “To the best of our knowledge, this is the first epidemiological study to demonstrate the association between anemia and the development of inflammatory bowel disease in the general population.”

The authors concluded that patients with anemia, especially newly developed anemia, were associated with an increased risk of developing CD, not UC. The risk of developing CD was inversely proportional to the hemoglobin level, which was a marker for anemia severity. A J-curve relationship was observed between age and the risk of developing CD among anemic patients, similar to that observed for the incidence of CD based on age. The study was published on September 8, 2020 in the journal PLOS ONE.

Related Links:
Seoul National University College of Medicine


New
Gold Member
Automatic Hematology Analyzer
DH-800 Series
Collection and Transport System
PurSafe Plus®
Automated Chemiluminescence Immunoassay Analyzer
MS-i3080
Rapid Molecular Testing Device
FlashDetect Flash10
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Immunology

view channel
Image: The CloneSeq-SV approach can allow researchers to study how cells within high-grade serous ovarian cancer change over time (Photo courtesy of MSK)

Blood Test Tracks Treatment Resistance in High-Grade Serous Ovarian Cancer

High-grade serous ovarian cancer (HGSOC) is often diagnosed at an advanced stage because it spreads microscopically throughout the abdomen, and although initial surgery and chemotherapy can work, most... Read more

Industry

view channel
Image: The collaboration aims to improve access to Hb variant testing with the Gazelle POC diagnostic platform (Photo courtesy of Hemex Health)

Terumo BCT and Hemex Health Collaborate to Improve Access to Testing for Hemoglobin Disorders

Millions of people worldwide living with sickle cell disease and other hemoglobin disorders experience delayed diagnosis and limited access to effective care, particularly in regions where testing is scarce.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.