We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Features Partner Sites Information LinkXpress
Sign In
Advertise with Us
Abbott Diagnostics

Download Mobile App




Events

ATTENTION: Due to the COVID-19 PANDEMIC, many events are being rescheduled for a later date, converted into virtual venues, or altogether cancelled. Please check with the event organizer or website prior to planning for any forthcoming event.
27 Oct 2020 - 31 Oct 2020
Virtual Venue
28 Oct 2020 - 30 Oct 2020
Virtual Venue

Hematological Parameters Evaluated for Cervicocranial Arterial Dissection Stroke

By LabMedica International staff writers
Posted on 23 Sep 2020
Print article
Image: the new XS-500ix Automated Hematology Analyzer (Photo courtesy of Sysmex Corporation).
Image: the new XS-500ix Automated Hematology Analyzer (Photo courtesy of Sysmex Corporation).
As artery detachment, artery dissection refers to the vascular disease in which blood flow enters the artery wall and causes dissection of vascular wall. Cervicocranial arterial dissection (CCAD) can lead to stenosis or occlusion of the lumen has become one of the most frequent causes for ischemic stroke in the young.

Patients with CCAD are frequently complicated by coagulopathy and neurological complications, which consisted of permanent neurological dysfunction such as acute ischemic stroke (AIS) and temporary neurological dysfunction such as headache, delirium, or a transient focal neurological deficit.

Neurologists at the First Affiliated Hospital of Soochow University (Suzhou, China) retrospectively analyzed 52 patients with AIS caused by CCAD from emergency room (group I), 51 patients with CCAD from emergency room or clinic (group II) and 52 controls (group III), age and sex matched. Data were collected on the admission including neutrophil to lymphocyte ratio (NLR) and lymphocyte to monocyte ratio (LMR). Blood count analysis was carried out using a Sysmex XS‐500i autoanalyzer (Sysmex Corporation, Kobe, Japan). The serum biochemical parameters were assayed by automatic ADVIA 1800 biochemical analyzer (Siemens Medical Solutions, Malvern, PA, USA).

The scientists reported that the NLR and LMR have significant differences among the three groups, especially in group I versus both groups II and III. There was a negative correlation between admission NLR and LMR. Low LMR level and high NLR level may be associated with severity of AIS caused by CCAD and significantly predict AIS in CCAD. The area under the curve of NLR and LMR were 0.77 and 0.71, respectively, on receiver operating characteristic curve analysis. The optimal cutoff values of NLR and LMR that best discriminated AIS were 2.35 (81% sensitivity and 63% specificity) and 3.67 (64% sensitivity and 77% specificity), respectively.

The authors concluded that NLR and LMR on admission as inflammatory biomarkers which might be useful in the diagnosis of AIS by CCAD. These reliable and easy‐to‐use predictors could contribute to clinical treatment strategy design in patients with CCAD. The study was published on September 7, 2020 in the Journal of Clinical Laboratory Analysis.

Related Links:
First Affiliated Hospital of Soochow University
Sysmex Corporation
Siemens Medical Solutions



Print article
BIOHIT  Healthcare OY

Channels

Molecular Diagnostics

view channel
Image: Photomicrograph of histology of a Ewing sarcoma in lung. The PAS stain highlights glycogen and the staining was negative with a PAS diastase stain (Photo courtesy of Nephron).

Comprehensive Molecular Profiling Matches Pediatric Patients to Therapies

A major challenge of using a comprehensive profiling approach for precision medicine is separating pathogenic from non-pathogenic molecular changes within a tumor. A program has been presented of the... Read more

Industry News

view channel
Image: Mindray Hematology Solution Helps High-Volume Lab Run 2,820,000 CBC Tests Annually (Photo courtesy of Mindray)

Mindray Hematology Solution Helps High-Volume Lab Run 2,820,000 CBC Tests Annually

High-volume laboratories face several challenges, including high instrument failure rate, errors due to several manual steps, low efficiency and long TAT, and heavier workload for the lab staff.... Read more
Copyright © 2000-2020 Globetech Media. All rights reserved.