Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
PURITAN MEDICAL

BECKMAN COULTER, INC.

Beckman Coulter develops, manufactures and markets laboratory systems, reagents, centrifugation, lab automation, elec... read more Featured Products: More products

Download Mobile App




Antimicrobial Therapy Biomarker Enumerates Eosinophil Count Changes

By LabMedica International staff writers
Posted on 01 Aug 2017
Eosinopenia as a criterion of sepsis has been the subject of debate for decades and the pathophysiology of eosinopenia is related to the migration of eosinophils to the inflammatory site, presumably as a result of chemotactic substances secreted during the acute phase of inflammation.

As a biomarker, eosinopenia has the advantage of not requiring further investigations, because it can be obtained easily from a simple complete blood count (CBC). More...
It has been hypothesized that recovery from eosinopenia during the treatment of bacterial infection may be a marker to evaluate whether a patient is receiving the appropriate antibiotic regimen.

Infectious disease specialists at the Raymond Poincaré Teaching Hospital (Garches, France) conducted a prospective study from February to August 2016. Hospitalized adults suffering from a bacterial infection with eosinopenia, defined as an eosinophil count less than 100/mm3, were included. Patients were divided into two groups according to the first day of effective antimicrobial therapy. They were observed for five days in order to evaluate whether recovery from eosinopenia was predictive of an appropriate antibiotic regimen. The eosinophil count was obtained from the CBC, acquired using a Coulter LH780 hematology analyzer.

The team screened 122 patients and 96 were included. In Group 1, 70 patients received effective antimicrobial therapy from day 0. Their eosinophil count increased significantly between day 0 and day 1. In the second group, 26 patients received delayed effective antimicrobial therapy, and there was no significant difference in eosinophil count between day 0 and day 1. Moreover, eosinophil counts normalized on day five in both groups. The mean duration of antimicrobial therapy was comparable in the two groups (7.7 ± 1.16 days). The antibiotics most often prescribed in both groups were intravenous cephalosporins. During follow-up, all patients were considered cured after day 30.

The authors concluded that the eosinophil count appears to normalize faster than C-reactive protein (CRP) and polymorphonuclear neutrophils in eosinopenic patients on appropriate antimicrobial therapy. This simple test is easy to perform as part of a regular complete blood count, with no additional costs as required for CRP or procalcitonin. The study was published in the August 2017 issue of the International Journal of Infectious Diseases.


Gold Member
Flocked Fiber Swabs
Puritan® Patented HydraFlock®
Serological Pipet Controller
PIPETBOY GENIUS
New
PlGF Test
Quidel Triage PlGF Test
New
Modular Hemostasis Automation Solution
CN Track
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








DIASOURCE (A Biovendor Company)

Channels

Immunology

view channel
Image: A simple blood test could replace surgical biopsies for early detecion of heart transplant rejection (Photo courtesy of Shutterstock)

Blood Test Detects Organ Rejection in Heart Transplant Patients

Following a heart transplant, patients are required to undergo surgical biopsies so that physicians can assess the possibility of organ rejection. Rejection happens when the recipient’s immune system identifies... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.