Features Partner Sites Information LinkXpress hp
Sign In
Advertise with Us
GLOBE SCIENTIFIC, LLC

SYSMEX-EUROPA

Sysmex Europe designs and produces laboratory and hematology diagnostic solutions, including instruments, reagents, c... read more Featured Products: More products

Download Mobile App




Plasma NT-ProBNP Levels Predict Severity of Enterovirus-71 Infection

By LabMedica International staff writers
Posted on 08 Dec 2016
Hand, foot, and mouth disease (HFMD) is caused by a variety of human enteroviruses, mainly by enterovirus 71 (EV71) and coxsackievirus A16 (CA16), and is characterized by fever and vesicular exanthema on the hands, feet, and mouth.

Brain-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are released in equimolar amounts from the myocardium. More...
Their levels increase in response to hemodynamic stress, and they have an established role in cardiovascular (vasodilation) and renal (natriuresis) physiology, conferring protection against fluid overload and hypertension.

Scientists at the Hunan Children's Hospital (Changsha, China) enrolled between January 2012 and December 2013, 282 patients from pediatric intensive care unit patients with HFMD, 183 (64.89%) were male and the median age of the cohort was 21 months. Cases were recorded as having severe HFMD if they were found to have the more serious complications including encephalitis, meningitis, acute flaccid paralysis, and cardiorespiratory failure, or died.

Venous blood sample for the detection of NT-proBNP was collected during the first hour of hospital admission and was stored immediately at −70 °C. The samples were centrifuged at 3,000 rpm for 20 minutes and analyzed using an electrochemiluminescence immunoassay (Elecsys NT-proBNP; bioMérieux, Lyons, France). The clinical caregivers were blinded to the NT-proBNP values in order to avoid changes to the clinical interventions based on the results. The red blood cell count (RBC), hemoglobin level (Hb), white blood cell (WBC) count, and neutrophil count (Neu) were determined using a Sysmex XE-2100 Automated Hematological Parameters Analyzer (Sysmex Corporation, Kobe, Japan).

The scientists found that NT-proBNP levels were significantly higher in patients with elevated blood glucose of greater than 7.8 mmol/L and increased white blood cell counts of greater than 14 × 109/L. HFMD patients who had no complications had significantly lower NT-proBNP values than patients who died or had complications. The team was able to discriminate between patients with and without brainstem encephalitis, pulmonary edema, pulmonary hemorrhage, circulatory failure, and death, respectively, using NT-proBNP. An NT-proBNP cut-off value of equal to or greater than 1,300 pg/mL demonstrated a high sensitivity of 85% and specificity of 93.5% for predicting death in critical HFMD patients. Children with severe EV71-associated HFMD and NT-proBNP measurements of greater than 1,300 pg/mL had significantly worse overall survival compared to those with levels less than 1,300 pg/mL.

The authors concluded that with the WBC count and blood glucose level, the NT-proBNP level can reflect the severity of EV71-associated HFMD, and NT-proBNP appears to be a better biomarker than the WBC count or hyperglycemia to discriminate severe HFMD patients with or without severe complications. NT-proBNP levels may be able to predict complications or mortality in children with severe EV71-associated HFMD disease in the intensive care unit. The study was published on November 3, 2016, in the International Journal of Infectious Diseases.

Related Links:
Hunan Children's Hospital
bioMérieux
Sysmex

New
Gold Member
Blood Gas Analyzer
Stat Profile pHOx
3-Part Differential Hematology Analyzer
Swelab Alfa Plus Sampler
New
Host Response Immunoassay Test
MeMed BV
New
Anti-Thyroid Peroxidase Assay
LIAISON Anti-TPO
Read the full article by registering today, it's FREE! It's Free!
Register now for FREE to LabMedica.com and get access to news and events that shape the world of Clinical Laboratory Medicine.
  • Free digital version edition of LabMedica International sent by email on regular basis
  • Free print version of LabMedica International magazine (available only outside USA and Canada).
  • Free and unlimited access to back issues of LabMedica International in digital format
  • Free LabMedica International Newsletter sent every week containing the latest news
  • Free breaking news sent via email
  • Free access to Events Calendar
  • Free access to LinkXpress new product services
  • REGISTRATION IS FREE AND EASY!
Click here to Register








Channels

Immunology

view channel
Image: A simple blood test could replace surgical biopsies for early detecion of heart transplant rejection (Photo courtesy of Shutterstock)

Blood Test Detects Organ Rejection in Heart Transplant Patients

Following a heart transplant, patients are required to undergo surgical biopsies so that physicians can assess the possibility of organ rejection. Rejection happens when the recipient’s immune system identifies... Read more

Pathology

view channel
These images illustrate how precision oncology Organ Chips recapitulate individual patients’ responses to chemotherapy (Photo courtesy of Wyss Institute at Harvard University)

Cancer Chip Accurately Predicts Patient-Specific Chemotherapy Response

Esophageal adenocarcinoma (EAC), one of the two primary types of esophageal cancer, ranks as the sixth leading cause of cancer-related deaths worldwide and currently lacks effective targeted therapies.... Read more
Copyright © 2000-2025 Globetech Media. All rights reserved.